Development of the first protease multiplex immunoassay for active neutrophilic serine protease biomarkers

D. McCafferty (Belfast (Belfast), United Kingdom), K. Moffitt (Belfast (Belfast), United Kingdom), T. Ferguson (Belfast (Belfast), United Kingdom)

Source: Virtual Congress 2021 – Biomarkers for the management of bronchial obstructive diseases
Session: Biomarkers for the management of bronchial obstructive diseases
Session type: E-poster
Number: 1143

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. McCafferty (Belfast (Belfast), United Kingdom), K. Moffitt (Belfast (Belfast), United Kingdom), T. Ferguson (Belfast (Belfast), United Kingdom). Development of the first protease multiplex immunoassay for active neutrophilic serine protease biomarkers. 1143

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Increased detection of interleukin-;5 in sputum by addition of protease inhibitors
Source: Eur Respir J 2001; 18: 685-691
Year: 2001



Development of a novel immunoassay for the measurement of active plasmin in patients with IPF
Source: International Congress 2017 – Chronic airway disease: markers of disease impact
Year: 2017


The development of a novel immunoassay for the quantification of active tryptase
Source: International Congress 2017 – Chronic airway disease: markers of disease impact
Year: 2017


Validation of an activity-based immunoassay for measurement of active cathepsin g in sputum
Source: Virtual Congress 2020 – Biomarkers and characterisation of immune response in respiratory infection
Year: 2020


LSC Abstract – A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition
Source: Eur Respir J 2011; 37: 1083-1090
Year: 2011



Impact of SARS-CoV-2 heat inactivation on active protease biomarkers in sputum sol
Source: Virtual Congress 2021 – Back to infection basics
Year: 2021


A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection
Source: Lung Science Conference 2015
Year: 2015

Evaluating a CD63 assay as a biomarker for SYK inhibitor activity
Source: Virtual Congress 2020 – Scientific advances in airway pharmacology
Year: 2020


Development of secretory leukocyte protease inhibitor (SLPI) variants resistant to degradation by neutrophil elastase
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014

Secretory leukocyte proteinase inhibitor in lung cancer: an immunohistochemical and serological study
Source: Eur Respir J 2006; 28: Suppl. 50, 388s
Year: 2006

Human airway trypsin-like protease stimulates protease activated receptors and interactions of these receptors
Source: International Congress 2019 – Immunopathological mechanisms of lung disease
Year: 2019

Plasma level of Mannose-binding lectin-associated serine protease (MASP-2) concentration in children with asthma.
Source: Virtual Congress 2021 – Biomarkers and risk factors in childhood asthma
Year: 2021


New enzyme linked immunosorbent assay using recombinant antigens from Saccharopolyspora rectivirgula for farmer‘s lung disease serodiagnosis
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012


Lysosomal cysteine proteases in the lung: role in protein processing and immunoregulation
Source: Eur Respir J 2004; 23: 620-628
Year: 2004



Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
Source: Annual Congress 2011 - Molecular pathology and functional genomics of lung disease
Year: 2011


Alpha-1 antitrypsin genotypes and associated inhibitory activity towards neutrophil serine proteinases, in vivo
Source: International Congress 2015 – Translational research in respiratory care: new findings
Year: 2015

Expression of cysteine proteases in sarcoidosis and tuberculosis
Source: Eur Respir J 2001; 18: Suppl. 33, 75s
Year: 2001

In vitro and in vivo characterisation of the novel neutrophil elastase inhibitor BI 1323495
Source: Virtual Congress 2020 – Scientific advances in airway pharmacology
Year: 2020