Effect of Nintedanib in a rat model of bleomycin-induced lung fibrosis: a transcriptome analysis

M. Bonatti (Parma, Italy), V. Pitozzi (Parma, Italy), P. Caruso (Parma, Italy), S. Pontis (Parma, Italy), M. Pittelli (Parma, Italy), C. Frati (Parma, Italy), D. Madeddu (Parma, Italy), F. Quaini (Parma, Italy), C. Lagrasta (Parma, Italy), M. Civelli (Parma, Italy), S. Ottonello (Parma, Italy), G. Villetti (Parma, Italy), M. Trevisani (Parma, Italy), B. Montanini (Parma, Italy)

Source: Virtual Congress 2021 – Developments in biomarkers and treatment strategies for chronic lung diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Bonatti (Parma, Italy), V. Pitozzi (Parma, Italy), P. Caruso (Parma, Italy), S. Pontis (Parma, Italy), M. Pittelli (Parma, Italy), C. Frati (Parma, Italy), D. Madeddu (Parma, Italy), F. Quaini (Parma, Italy), C. Lagrasta (Parma, Italy), M. Civelli (Parma, Italy), S. Ottonello (Parma, Italy), G. Villetti (Parma, Italy), M. Trevisani (Parma, Italy), B. Montanini (Parma, Italy). Effect of Nintedanib in a rat model of bleomycin-induced lung fibrosis: a transcriptome analysis. 731

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Time-course analysis of bleomycin-induced lung fibrosis in the rat
Source: International Congress 2018 – Pulmonary fibrosis: from models to patients
Year: 2018

Quantitation of hydroxyproline in a mouse model of bleomycin-induced lung fibrosis: comparison with histological analysis
Source: International Congress 2019 – New mechanistic insights into pulmonary fibrosis
Year: 2019

Evolution of biomechanical changes in a murine model of bleomycin-induced lung fibrosis: inflammation versus fibrosis
Source: Eur Respir J 2006; 28: Suppl. 50, 396s
Year: 2006

The effect of pravastatin on bleomycin-induced lung injury and fibrosis in mouse
Source: Annual Congress 2010 - Determinants of acute lung injury and fibrosis
Year: 2010

Comparative analysis of collagen quantification in the bleomycin mouse model of lung fibrosis
Source: Virtual Congress 2020 – Diagnostic and prognostic markers for disease-associated interstitial lung disease and hypersensitivity pneumonitis
Year: 2020


Effect of Nintedanib in a rat model of lung fibrosis induced by single or double bleomycin administration
Source: International Congress 2017 – The wide spectrum of ILDs
Year: 2017


A longitudinal characterization of lymphangiogenesis in bleomycin-induced pulmonary fibrosis mouse model
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012

Chronic intermittent hypoxia exacerbates lung fibrosis in bleomycin-induced lung injury mouse model
Source: International Congress 2018 – Sleep-disordered breathing: cardiovascular consequences, epidemiology, phenotypes and comorbidities
Year: 2018



Correlation of Nintedanib efficacy on fibrotic lesion deposition and lung function within a rat IPF model
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

Reduction of lung injury and fibrosis by human embrionic stem cells in a mouse model of silica-induced lung fibrosis
Source: Annual Congress 2011 - Experimental models and research in diffuse parenchymal lung diseases
Year: 2011

PBI-compound, a novel first-in-class anti-fibrotic compound, reduces lung fibrosis in the bleomycin-induced lung fibrosis model: A comparative study with pirfenidone
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013


Late Breaking Abstract - PRRX1 inhibition decreases fibrosis in the bleomycin-induced lung fibrosis model in mice
Source: International Congress 2018 – Regenerative and anti-fibrotic approaches
Year: 2018


Effect of nintedanib on silica-induced lung inflammation and fibrosis in mice
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012


Late Breaking Abstract - MIF inhibition in a murine model of bleomycin-induced lung fibrosis
Source: International Congress 2018 – Molecular mechanisms and treatment of pulmonary hypertension
Year: 2018



Comparison of expression of napsin A and surfactant protein D in bleomycin-induced pulmonary fibrosis mouse model
Source: Annual Congress 2013 –Diffuse parenchymal lung disease I
Year: 2013

Aerobic exercise can impair lung fibrotic and functional response in a model of bleomycin-induced lung fibrosis: a time-dependent effect
Source: International Congress 2017 – Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Year: 2017

Comparison of in-vivo anti-fibrotic effects of pirfenidone and nintedanib in bleomycin-induced pulmonary fibrosis model
Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2019

Pharmacological validation of a new IPF bleomycin-induced mouse model
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

PBI-compound, a novel first-in-class anti-fibrotic compound, inhibits CTGF and collagen production in murine and human fibroblasts, and reduces lung fibrosis in the bleomycin-induced lung fibrosis model
Source: Annual Congress 2013 –Cell signalling and inflammation: what's new in 2013?
Year: 2013


Effect of intratracheal administration of adipose-derived stromal cells on bleomycin-induced lung injury in a rat model
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015