A single blood eosinophil count measurement is as good as two for prediction of ICS treatment response in the IMPACT trial

Mona Bafadhel, Neil Barnes, Stephen C. Bourke, Chris Compton, Gerard J. Criner, Mark T. Dransfield, David M.G. Halpin, MeiLan K. Han, Benjamin Hartley, C. Elaine Jones, Peter Lange, Sally Lettis, David A. Lipson, David A. Lomas, Neil Martin, Fernando J. Martinez, Robert Wise, Dave Singh

Source: Eur Respir J, 58 (3) 2004522; 10.1183/13993003.04522-2020
Journal Issue: September
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Mona Bafadhel, Neil Barnes, Stephen C. Bourke, Chris Compton, Gerard J. Criner, Mark T. Dransfield, David M.G. Halpin, MeiLan K. Han, Benjamin Hartley, C. Elaine Jones, Peter Lange, Sally Lettis, David A. Lipson, David A. Lomas, Neil Martin, Fernando J. Martinez, Robert Wise, Dave Singh. A single blood eosinophil count measurement is as good as two for prediction of ICS treatment response in the IMPACT trial. Eur Respir J, 58 (3) 2004522; 10.1183/13993003.04522-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Analysis of IMPACT: is one blood eosinophil count measurement sufficient to predict ICS treatment response in COPD?
Source: International Congress 2019 – COPD clinical trials: new molecules and novel insights
Year: 2019



Response to omalizumab treatment according to blood eosinophil count: Results of a French real-world study (STELLAIR)
Source: International Congress 2017 – Asthma: mechanisms and treatment
Year: 2017

Cost-effectiveness of single-inhaler triple therapy for chronic obstructive pulmonary disease treatment by baseline blood eosinophil count: IMPACT trial
Source: Virtual Congress 2021 – Difficult decisions on expected outcomes: availability of hospital resources and improvement of treatment adherence
Year: 2021



Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD
Source: Eur Respir J, 55 (5) 1902119; 10.1183/13993003.02119-2019
Year: 2020



Are peripheral blood eosinophil counts a guideline for omalizumab treatment? STELLAIR says no!
Source: Eur Respir J, 51 (5) 1800730; 10.1183/13993003.00730-2018
Year: 2018



Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
Source: Eur Respir J, 51 (5) 1702523; 10.1183/13993003.02523-2017
Year: 2018



The blood eosinophil count as a biomarker in COPD
Source: International Congress 2015 – Individualised risk reduction strategies for patients with COPD
Year: 2015



Blood eosinophil count as a predictor of treatment response in adult patients with chronic cough
Source: Virtual Congress 2020 – Asthma and cough: clinical trials and pharmacological insights
Year: 2020


The reproducibility of COPD blood eosinophil counts
Source: Eur Respir J, 52 (1) 1800427; 10.1183/13993003.00427-2018
Year: 2018



Late Breaking Abstract - Blood eosinophil count (EOS) can accurately predict responsiveness to inhaled corticosteroids (ICS) in COPD, but only if measured while patients are not receiving steroids.
Source: International Congress 2018 – COPD: from LABA/ICS to LABA/LAMA/ICS
Year: 2018




Asthma treatment based on sputum cell counts or usual clinical outcomes: the LOMA study
Source: Eur Respir J 2003; 22: Suppl. 45, 35s
Year: 2003

Clinical significance of blood neutrophil differential count in patients with COPD
Source: International Congress 2017 – Biomarker-based asthma control
Year: 2017

Peripheral blood eosinophil counts in COPD patients and its relationship with prescription of inhaled corticosteroid in real world setting in Japan.
Source: International Congress 2017 – Airway disease and exacerbations
Year: 2017

Low versus high Th2 asthma: variability of blood eosinophil counts in a longitudinal analysis
Source: Virtual Congress 2021 – Severe asthma: evaluation using patient-reported outcome measures (PROMs) and biomarkers, comorbidities and treatments
Year: 2021


High eosinophil counts predict decline in FEV1: results from the CanCOLD study
Source: Eur Respir J, 57 (5) 2000838; 10.1183/13993003.00838-2020
Year: 2021



Automated cell differential count in sputum is feasible and comparable to manual cell count in identifying eosinophilia
Source: International Congress 2019 – Research and innovation in airway diseases
Year: 2019


Blood eosinophil (EOS) count, exacerbation rate and response to roflumilast in patients with severe COPD
Source: International Congress 2017 – What is new in COPD management and prognosis: findings from large studies?
Year: 2017


Long-term omalizumab treatment – do drug concentration levels count?
Source: Virtual Congress 2020 – Personalised treatment of obstructive diseases
Year: 2020


Accuracy of blood eosinophil count in predicting sputum eosinophils in children with problematic severe asthma (PSA)
Source: Virtual Congress 2020 – Novel mechanisms and management of paediatric asthma
Year: 2020


Impact of blood eosinophil variability in asthma: a real-life population study.
Source: Virtual Congress 2021 – Clinical features and new biomarkers of asthma, COPD and chronic cough
Year: 2021