Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes

Fabrizio Maggi, Alfredo Rosellini, Pietro Giorgio Spezia, Daniele Focosi, Lisa Macera, Michele Lai, Mauro Pistello, Antonio de Iure, Carlo Tomino, Stefano Bonassi, Patrizia Russo

Source: ERJ Open Res, 7 (2) 00713-2020; 10.1183/23120541.00713-2020
Journal Issue: April

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Fabrizio Maggi, Alfredo Rosellini, Pietro Giorgio Spezia, Daniele Focosi, Lisa Macera, Michele Lai, Mauro Pistello, Antonio de Iure, Carlo Tomino, Stefano Bonassi, Patrizia Russo. Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes. ERJ Open Res, 7 (2) 00713-2020; 10.1183/23120541.00713-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Angiotensin II activates the hypoxia-responsive-element (HRE) in human alveolar epithelial cells
Source: Eur Respir J 2001; 18: Suppl. 33, 79s
Year: 2001

mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19
Source: Eur Respir J, 57 (2) 2002737; 10.1183/13993003.02737-2020
Year: 2021



Modulation of NOS2 expression in co-cultures of human alveolar epithelial cells type II and alveolar macrophages
Source: Eur Respir J 2001; 18: Suppl. 33, 161s
Year: 2001

TGF-β modulates Na+,K+-ATPase expression and activity in the lung epithelium
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008


Effect of hypoxia on gene regulation and differentiation in alveolar epithelial type II cells
Source: Eur Respir J 2001; 18: Suppl. 33, 162s
Year: 2001

High concentrations of VEGF reduce stretch-induced apoptosis of alveolar type II cells
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Role of TGF-b1 in type I collagen production in bronchial epithelial cells: effects on Smad7 inhibitory role?
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008


Muscarinic receptors mediate up-regulation of endothelin-1 expression in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

TNF-α and TGF-β1 synergistically upregulate the expression of endothelin-1 in airway epithelial cell
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009

Cigarette smoke significantly reduces proliferation and modulates the expression levels of CEBPα and CEBPβ in cultured human lung fibroblasts
Source: Annual Congress 2008 - Basic science in asthma and COPD II
Year: 2008


IL-13 induces glucocorticoid resistance in iNOS expression and activity in human airway epithelial cells (HAECs)
Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Year: 2017


Overexpression of the SARS-CoV-2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia
Source: Virtual Congress 2021 – Tobacco and nicotine research during the pandemic
Year: 2021



Dexamethasone inhibits LPS-induced expression of human β-defensin-2 via down-regulation of TLR4
Source: Eur Respir J 2003; 22: Suppl. 45, 562s
Year: 2003

Expression of dopamine receptors in human alveolar macrophages
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010


Cigarette smoke upregulates IL-8/CXCL8 expression by augmenting mRNA stability via p38 MAPK/MK2 signalling in normal human pulmonary cells
Source: Annual Congress 2012 - Basic and translational studies in COPD
Year: 2012


Oral Presentation: The functional role of the Frizzled-8 receptor TGF-beta1-induced activation and extracellular matrix production in human lung fibroblasts
Source: Lung Science Conference 2012 - Rebuilding a diseased lung: Repair and regeneration
Year: 2012

Wnt11 inhibits epithelial-mesenchymal transition induced by TGFb1 in human type II alveolar epithelial cells
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012


Kaempferol-induced HO-1 expression attenuated inflammation in human pulmonary alveolar epithelial cells
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017


Effects of phosphodiesterase-4 inhibitors on surfactant protein-A expression in adult alveolar epithelial cells type II
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


Profiling of gene expressions induced by TGF-β1 and cyclosporine a in alveolar cells in vitro
Source: Annual Congress 2009 - Bronchoalveolar lavage and phenotyping in diffuse parenchymal lung disease
Year: 2009