Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis

Antoine Froidure, Emmeline Marchal-Duval, Meline Homps-Legrand, Mada Ghanem, Aurélien Justet, Bruno Crestani, Arnaud Mailleux

Source: Eur Respir Rev, 29 (158) 190140; 10.1183/16000617.0140-2019
Journal Issue: December
Disease area: Interstitial lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Antoine Froidure, Emmeline Marchal-Duval, Meline Homps-Legrand, Mada Ghanem, Aurélien Justet, Bruno Crestani, Arnaud Mailleux. Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis. Eur Respir Rev, 29 (158) 190140; 10.1183/16000617.0140-2019

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PP208 – SRC family kinases modulate molecular pathways associated with mitochondrial dysfunction in idiopathic pulmonary fibrosis
Source: ERS Lung Science Conference 2021
Year: 2021

Involvement of the Hedgehog signalling pathway in idiopathic pulmonary fibrosis
Source: Annual Congress 2011 - Growth factors and fibrogenesis: are they good, bad or both?
Year: 2011

Dysregulation of the TGF-beta system in idiopathic pulmonary fibrosis
Source: Eur Respir J 2004; 24: Suppl. 48, 10s
Year: 2004

mTOR signalling is an essential pathway for TGF-β1 induced collagen synthesis
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015

Defective p53-mediated pro-apoptotic pathway in idiopathic pulmonary fibrosis
Source: Annual Congress 2008 - New insights into the pathogenesis of idiopathic pulmonary fibrosis and sarcoidosis
Year: 2008

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Increased pulmonary Wnt signaling in patients with sarcoidosis
Source: Annual Congress 2007 - Interstitial lung disease: diagnostic and therapeutic novelties
Year: 2007


The matrix-fibroblast interplay contributes to HIF-1 alpha pathway activation: a possible therapeutic target in idiopathic pulmonary fibrosis (IPF)
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




TRIM33 prevents pulmonary fibrosis by impairing TGF-ß1 signalling
Source: Eur Respir J, 55 (6) 1901346; 10.1183/13993003.01346-2019
Year: 2020



Wnt signalling and parenchymal fibrosis
Source: Lung Science Conference 2009 - Cell proliferation, Differentiation and Carcinogenesis
Year: 2009


Non-canonical WNT signaling is mediated by extracellular vesicles in pulmonary fibrosis
Source: ERS Lung Science Conference 2016
Year: 2016

Four-and-a-half-LIM-domain (FHL)-2 acts as an enhancer of TGF-beta signaling in pulmonary fibrosis
Source: Eur Respir J 2007; 30: Suppl. 51, 296s
Year: 2007

LSC - 2021 - SRC family kinases modulate molecular pathways associated with mitochondrial dysfunction in idiopathic pulmonary fibrosis
Source: Virtual Congress 2021 – Cellular and molecular involvement in lung injury and repair
Year: 2021



Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway
Source: Virtual Congress 2020 – Translational therapeutic advances
Year: 2020


LSC Abstract – Non-canonical WNT signaling is mediated by extracellular vesicles in pulmonary fibrosis
Source: International Congress 2016 – New genomic targets in pulmonary disease
Year: 2016


Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis
Source: Eur Respir J, 57 (4) 2000652; 10.1183/13993003.00652-2020
Year: 2021



Targeting the mTOR signaling pathway to inhibit lung cell senescence in chronic obstructive pulmonary disease (COPD)
Source: ERS Lung Science Conference 2017
Year: 2017

Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis
Source: Eur Respir J 2016; 48: 538-552
Year: 2016