Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space

Sarah Orfanos, Ibrahim El Husseini, Thomas Nahass, Jared Radbel, Sabiha Hussain

Source: ERJ Open Res, 6 (4) 00455-2020; 10.1183/23120541.00455-2020
Journal Issue: October
Disease area: Respiratory critical care

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Sarah Orfanos, Ibrahim El Husseini, Thomas Nahass, Jared Radbel, Sabiha Hussain. Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space. ERJ Open Res, 6 (4) 00455-2020; 10.1183/23120541.00455-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The regulation of plasminogen activator inhibitor-1 (PAI-1) production with dexamethasone by human lung fibroblasts
Source: Eur Respir J 2005; 26: Suppl. 49, 343s
Year: 2005

Upregulation of the gene encoding the urokinase-type plasminogen activator (uPA) in respiratory muscles of COPD patients
Source: Annual Congress 2004 - Skeletal muscle in respiratory disease
Year: 2004


Half - dose of recombinant tissue-type plasminogen activator in the treatment of acute pulmonary embolism: long term outcomes
Source: International Congress 2017 – Prognostic factors and outcomes in pulmonary embolism
Year: 2017


Pro-urokinase up-regulates the expression of urokinase type plasminogen activator (u-PA) in human pulmonary arterial endothelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 143s
Year: 2007

The biological effect of intrapleural tissue plasminogen (tPA) activator and DNase delivery in pleural infection patients.
Source: International Congress 2018 – New therapies for respiratory infections: experimental and translational studies
Year: 2018



Enoxaparin reduced ventilation-induced plasminogen activator inhibitor-1
Source: Annual Congress 2009 - Crossing the line: alveolo-capillary barrier control in acute lung injury
Year: 2009



Soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in exacerbated COPD
Source: International Congress 2018 – New predictors of morbidity and mortality in COPD
Year: 2018



Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010

The relation between plasminogen activator inhibitor-1 (PAI-1) and inflammatory markers in COPD: A possible risk factor of inflammation-induced thrombosis
Source: International Congress 2017 – Systemic and airway biomarkers
Year: 2017

Outcomes of intrapleural tissue plasminogen activator (tPA) and deoxyribnuclease (DNase) for IPC-related pleural infection
Source: International Congress 2019 – Pleural infection and complicated pneumonia
Year: 2019


Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 suppresses allergic asthma in a murine model
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

The effect of prostaglandin (PG) E2 and its receptor antagonists on urokinase-type plasminogen activator (uPA) production by human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 811s
Year: 2006

Comparison of intrapleural use of urokinase and tissue plasminogen activator/DNAse in pleural infection
Source: ERJ Open Res, 5 (3) 00084-2019; 10.1183/23120541.00084-2019
Year: 2019



Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma
Source: Eur Respir J 2016; 47:1568-1571
Year: 2016


Soluble urokinase plasminogen activator receptor (suPAR) is associated with COPD readmission and mortality
Source: International Congress 2019 – Long-term lung function: from early birth to adulthood
Year: 2019




LATE-BREAKING ABSTRACT: Molecular mechanisms of plasminogen activator inhibitor-1 elevation in COPD sputum
Source: Annual Congress 2012 - Cell biology and inflammatory gene expression in chronic lung disease
Year: 2012

Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia
Source: ERJ Open Res, 5 (1) 00212-2018; 10.1183/23120541.00212-2018
Year: 2019



Plasminogen activator inhibitor-1 (PAI-1) mutations of extended half-life time inhibit angiogenic properties of human lung microvascular endothelial cells (HMVEC-L)
Source: Eur Respir J 2003; 22: Suppl. 45, 225s
Year: 2003

Human lung microvascular endothelial cells (HMVEC-L) angiogenic activity is inhibited by stable plasminogen activator inhibitor-1 (PAI-1) mutants via urokinase-dependent pathway
Source: Annual Congress 2004 - Lung development and cancer
Year: 2004


Urokinase type plasminogen activator improves airway inflammation and mucin expression in a murine asthma model
Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2010