Safety and efficacy of P2X3 antagonist BAY 1902607 in refractory chronic cough

C. Friedrich (Berlin, Germany), K. Francke (Berlin, Germany), S. Birring (London, United Kingdom), J. Van Den Berg (Zwolle, Netherlands), P. Marsden (Manchester, United Kingdom), L. Mcgarvey (Belfast, United Kingdom), A. Turner (Birmingham, United Kingdom), P. Wielders (Eindhoven, Netherlands), I. Gashaw (Berlin, Germany), S. Klein (Berlin, Germany), A. Morice (Cottingham, E Yorkshire, United Kingdom)

Source: Virtual Congress 2020 – Chronic cough: only symptom or disease?
Session: Chronic cough: only symptom or disease?
Session type: Oral Presentation
Number: 4566
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Friedrich (Berlin, Germany), K. Francke (Berlin, Germany), S. Birring (London, United Kingdom), J. Van Den Berg (Zwolle, Netherlands), P. Marsden (Manchester, United Kingdom), L. Mcgarvey (Belfast, United Kingdom), A. Turner (Birmingham, United Kingdom), P. Wielders (Eindhoven, Netherlands), I. Gashaw (Berlin, Germany), S. Klein (Berlin, Germany), A. Morice (Cottingham, E Yorkshire, United Kingdom). Safety and efficacy of P2X3 antagonist BAY 1902607 in refractory chronic cough. 4566

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Safety and efficacy of the inhaled pan-selectin antagonist bimosiamose in patients with COPD
Source: Eur Respir J 2007; 30: Suppl. 51, 613s
Year: 2007

The efficacy and safety of long-acting muscarinic antagonist treatment for COPD
Source: International Congress 2019 – Advances in chronic obstructive pulmonary disease and asthma
Year: 2019


Safety and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in patients with COPD
Source: Annual Congress 2008 - Novel treatments for respiratory disease
Year: 2008

Efficacy and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients
Source: Annual Congress 2007 - Mechanisms and new treatments of COPD
Year: 2007


An open-label pilot study of memantine, an N-methyl-D-aspartate receptor antagonist in chronic cough
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

Efficacy and safety of aclidinium bromide, a novel long-acting muscarinic antagonist, in patients with moderate to severe COPD
Source: Annual Congress 2009 - New bronchodilators
Year: 2009

Safety and efficacy of SCH527123, a novel CXCR2 antagonist, in patients with COPD
Source: Annual Congress 2010 - Novel anti-inflammatory agents for airway disease
Year: 2010

Characterization of chronic cough patients participating in a phase 2b clinical trial of gefapixant, a P2X3 receptor antagonist
Source: International Congress 2019 – Highlights in lung function and chronic cough
Year: 2019


The effect of baseline factors on treatment response with MK-7264, a P2X3 antagonist, in refractory chronic cough.
Source: International Congress 2018 – Management of chronic cough and respiratory muscle dysfunction
Year: 2018

Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients
Source: Annual Congress 2009 - New drugs for airways disease
Year: 2009

Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011

An oral selective M3 cholinergic receptor antagonist in COPD
Source: Eur Respir J 2006 Oct 01;28(4):772-780
Year: 2006



Pharmacological profile of a novel, potent and oral TRPA1 antagonist. Characterization in a preclinical model of induced cough
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

Design of phase 2b randomised controlled trial of S-600918, P2X3 receptor antagonist for refractory chronic cough
Source: Virtual Congress 2020 – Asthma and cough: clinical trials and pharmacological insights
Year: 2020


Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


Dose-ranging study to assess the efficacy and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in patients with COPD
Source: Annual Congress 2008 - Pathogenesis and treatment of asthma and COPD
Year: 2008

Sustained efficacy with the selective endothelin-A receptor antagonist, sitaxsentan, after two years of therapy in patients with pulmonary arterial hypertension
Source: Eur Respir J 2005; 26: Suppl. 49, 204s
Year: 2005

LATE-BREAKING ABSTRACT: Inhibition of ATP-gated P2X3 channels by AF-219: An effective anti-tussive mechanism in chronic cough
Source: Annual Congress 2013 –Hot topics on airway diseases: new horizons in treatment
Year: 2013

The safety and tolerability of twice-daily oral doses of AZD5069, a novel CXCR2 antagonist, in patients with moderate-to-severe COPD
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

Baseline patient burden in chronic cough from a Phase 2b clinical trial of gefapixant, a P2X3 receptor antagonist
Source: International Congress 2019 – Highlights in lung function and chronic cough
Year: 2019