Blocking Focal adhesion kinase (FAK) protects against damage in a novel model of lymphocyte dominant lung injury

D. Brister (Calgary, Canada), G. Aulakah (Saskatoon, Canada), H. Zhang (Calgary, Canada), K. Patel (Calgary, Canada)

Source: Virtual Congress 2020 – Cellular involvement in lung injury
Session: Cellular involvement in lung injury
Session type: Oral Presentation
Number: 4469
Disease area: Interstitial lung diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Brister (Calgary, Canada), G. Aulakah (Saskatoon, Canada), H. Zhang (Calgary, Canada), K. Patel (Calgary, Canada). Blocking Focal adhesion kinase (FAK) protects against damage in a novel model of lymphocyte dominant lung injury. 4469

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL18 induces p38 MAP kinase activation and adhesion capacities in BMPRII knocked down human lung microvascular endothelial cells
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

Romidepsin (FK228) target focal adhesion kinase (FAK) expression in lung fibrosis
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015


Mitogen activated protein kinase activated protein kinase 2 regulates actin stress fiber formation in ventilator associated lung injury
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008

FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl
Source: Eur Respir J 2011; 37: 78-88
Year: 2011



p38 MAP kinase mediates apoptosis related to ventilator associated lung injury
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008

Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

Potential role of filamin and p38 MAPK in the regulation of human alveolar epithelial cell permeability
Source: Eur Respir J 2002; 20: Suppl. 38, 96s
Year: 2002

Eosinophil adhesion to cholinergic nerve cells induces NFκB activation via the interleukin-1 receptor associated kinase (IRAK) pathway and upregulates ICAM-1 expression
Source: Eur Respir J 2003; 22: Suppl. 45, 10s
Year: 2003

The nitration mediated inhibition of Rac1 is involved in the endothelial barrier dysfunction induced by lipopolysaccharide
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011

Activated protein C protection in endotoxin-induced lung injury is mediated by lung matrix metalloproteinases activity
Source: Annual Congress 2007 - Miscellaneous lower respiratory tract infections
Year: 2007


The pan janus kinase (JAK) inhibitor KN-002 suppresses inflammatory mediator release from severe asthma bronchial epithelial cells.
Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science
Year: 2021


Transmission of muscarinic receptor mediated proliferative effects in human lung fibroblasts involves ERK-MAP kinase, but not PI-3 kinase and Rho-kinase pathway
Source: Annual Congress 2007 - Miscellaneous pulmonary pharmacology
Year: 2007


TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 718s
Year: 2004

Stimulation of NOD1 induces RIP2, TAK1 and p38 MAPK dependent pro-inflammatory signalling in human lung microvascular endothelial cells
Source: Annual Congress 2011 - Mechanisms of acute lung injury and mesenchymal cell treatment
Year: 2011


Protein tyrosine phosphatase-alpha (PTPa) promotes profibrotic responses in lung fibroblasts
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

A differential role for ceramide kinase in antigen/FcεRI mediated mast cell activation and function
Source: Eur Respir J 2006; 28: Suppl. 50, 231s
Year: 2006

Phosphorylation of HSP27 potentiates endothelial cell death
Source: Annual Congress 2010 - Pulmonary vascular diseases
Year: 2010

Inhibition of neutrophil apoptosis by sphingosin-1-phopsphate through the activation of neutral sphingomyelinase in acute lung injury
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

MAPK inhibition modulates Hsp27 phosphorylation and glutathione in lung epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 192s
Year: 2006

Protease activated receptor-1 (PAR-1) stimulation leads to αvβ6 integrin mediated TGFβ activation via rho kinase
Source: Eur Respir J 2005; 26: Suppl. 49, 238s
Year: 2005