HIF pathway activation is a core regulator of collagen structure-function in lung fibrosis

C. Brereton (Southampton, United Kingdom), R. Ridley (Southampton, United Kingdom), F. Conforti (Southampton, United Kingdom), L. Yao (Southampton, United Kingdom), A. Alzetani (Southampton, United Kingdom), B. Marshall (Southampton, United Kingdom), S. Fletcher (Southampton, United Kingdom), L. Richeldi (Rome, Italy), Y. Wang (Southampton, United Kingdom), D. Davies (Southampton, United Kingdom), M. Jones (Southampton, United Kingdom)

Source: Virtual Congress 2020 – Lung epithelial development and repair in three-dimensions
Session: Lung epithelial development and repair in three-dimensions
Session type: Oral Presentation
Number: 4323
Disease area: Interstitial lung diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Brereton (Southampton, United Kingdom), R. Ridley (Southampton, United Kingdom), F. Conforti (Southampton, United Kingdom), L. Yao (Southampton, United Kingdom), A. Alzetani (Southampton, United Kingdom), B. Marshall (Southampton, United Kingdom), S. Fletcher (Southampton, United Kingdom), L. Richeldi (Rome, Italy), Y. Wang (Southampton, United Kingdom), D. Davies (Southampton, United Kingdom), M. Jones (Southampton, United Kingdom). HIF pathway activation is a core regulator of collagen structure-function in lung fibrosis. 4323

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Four-and-a-half-LIM-domain (FHL)-2 acts as an enhancer of TGF-beta signaling in pulmonary fibrosis
Source: Eur Respir J 2007; 30: Suppl. 51, 296s
Year: 2007

Regulation of alternative macrophage activation by galectin-3; potential role in lung fibrosis
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


PGAM5 acts as a key mediator of lung fibrosis by disrupting mitochondrial homeostasis
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

mTOR signalling is an essential pathway for TGF-β1 induced collagen synthesis
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015

The matrix-fibroblast interplay contributes to HIF-1 alpha pathway activation: a possible therapeutic target in idiopathic pulmonary fibrosis (IPF)
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




Coagulation in lung fibrosis: multiple pathways leading to fibroblast activation
Source: Annual Congress 2012 - PG11 Pulmonary fibrosis
Year: 2012

Gp130-Stat3 signalling regulates sensitivity to bleomycin induced lung fibrosis
Source: Eur Respir J 2006; 28: Suppl. 50, 604s
Year: 2006

17(R)-resolvinD1 mediates a pathway involving the transcription factor c-Fos to reduce bleomycin-induced pulmonary fibrosis in mice.
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018




Differential role of EPAC and PKA in the transduction of cAMP-mediated inhibition of human lung fibroblast proliferation and collagen synthesis
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagy
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

YI02 - Activation of Wnt/beta-catenin signaling promotes lung epithelial repair in emphysema
Source: Lung Science Conference 2012 - Rebuilding a diseased lung: Repair and regeneration
Year: 2012

6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway
Source: Virtual Congress 2020 – Translational therapeutic advances
Year: 2020


HIF dependent regulation of S100A4 protein in COPD induced vascular remodelling
Source: Annual Congress 2010 - Pulmonary circulation I
Year: 2010

TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 718s
Year: 2004

Expression of Smad proteins during myofibroblast differentiation in pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 267s
Year: 2005

iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Growth factor regulation of lung fibrosis lessons from other organs
Source: Annual Congress 2006 - Scientific year in review
Year: 2006


The pathomechanistic role of autophagy in lung fibrosis
Source: International Congress 2017 – Interstitial lung diseases (ILDs): novel pathogenetic pathways
Year: 2017

Extracellular HSP90a promotes cellular senescence in pulmonary fibrosis through TGFß signaling
Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more
Year: 2020