Effect of rifampin, a potent organic-anion-transporting polypeptide inhibitor (OATPi), on the PK of BMS-986278, a lysophosphatidic acid receptor (LPA1) antagonist

G. Tirucherai (Princeton, United States of America), Q. Ruan (Princeton, United States of America), D. Hawthorne (Princeton, United States of America), D. Yu (Raleigh, United States of America), R. Revankar (Princeton, United States of America), E. Charles (Princeton, United States of America)

Source: Virtual Congress 2020 – Clinical aspects and new treatment strategies for rare interstitial lung diseases in adults and children
Disease area: Interstitial lung diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. Tirucherai (Princeton, United States of America), Q. Ruan (Princeton, United States of America), D. Hawthorne (Princeton, United States of America), D. Yu (Raleigh, United States of America), R. Revankar (Princeton, United States of America), E. Charles (Princeton, United States of America). Effect of rifampin, a potent organic-anion-transporting polypeptide inhibitor (OATPi), on the PK of BMS-986278, a lysophosphatidic acid receptor (LPA1) antagonist. 3495

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
BMS-986278, a lysophosphatidic acid 1 (LPA1) receptor antagonist, in healthy participants: A single/multiple ascending dose (SAD/MAD) phase 1 study
Source: International Congress 2019 – The changing face of rare diffuse parenchymal lung diseases: recent advances in pathogenesis, clinical manifestations and treatment
Year: 2019


Protease-activated receptor 2 (PAR2) stimulation potentiates citric acid induced cough by sensitising the vanilloid receptor-1 (TRPV1)
Source: Annual Congress 2003 - Novel drugs under development for the treatment of respiratory diseases
Year: 2003


A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via activation of protein phosphatase PP2A
Source: Annual Congress 2011 - Phagocytes and dendritic cells
Year: 2011

Interaction of retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma
Source: Annual Congress 2012 - Asthma and the genes: from GWAS to next generation transcriptome analyses
Year: 2012

New drugs for pulmonary hypertension
Source: Eur Respir Mon 2012; 57: 233-246
Year: 2012


Cystenyl-leukotriene receptor antagonist (LRA) inhibits respiratory burst of human neutrophils
Source: Eur Respir J 2003; 22: Suppl. 45, 316s
Year: 2003

Molecular and cellular profile of the structurally novel phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

Mas receptor antagonist inhibits the pro-resolutive effects of Angiotensin-(1-7) in an experimental model of asthma.
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

The novel dual D2 dopamine receptor, β2-adrenoceptor agonist Viozan™ (AR-C68397AA) is well tolerated in a dog model
Source: Eur Respir J 2001; 18: Suppl. 33, 406s
Year: 2001

A new ultra-potent vanilloid receptor 1 (VR1) antagonist abates capsaicin and citric acid induced cough
Source: Eur Respir J 2002; 20: Suppl. 38, 190s
Year: 2002

The effect of leukotrienes and their receptor antagonists on calcium signalling in the cough receptors transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1)
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


The endocannabinoids anandamide and 2-arachidonyl-glycerol (2-AG) induce pulmonary hypertension (PH) in a CB1 receptor independent manner - role of COX-2 and EP1 receptor activation
Source: Eur Respir J 2005; 26: Suppl. 49, 733s
Year: 2005

Nicotinic alpha-7 receptor stimulation (a7nAChR) inhibited NF-kB/STAT3/SOCS3 pathways in a murine model of asthma.
Source: International Congress 2017 – Novel mechanisms and treatments for asthma
Year: 2017



Effects of CHF6297, a potent and selective p38a MAPK inhibitor, in murine models of steroid resistant lung inflammation
Source: International Congress 2017 – Towards new anti-inflammatory and anti-fibrotic agents
Year: 2017



The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 100s
Year: 2003

Phase 1 evaluation of the inhaled IL-4Ra antagonist, AZD1402/PRS-060, a potent and selective blocker of IL-4Ra
Source: International Congress 2019 – Novel findings from asthma clinical trials
Year: 2019




The phosphodiesterase 4 inhibitor SB 207499 selectively inhibits neutrophil functions
Source: Eur Respir J 2001; 18: Suppl. 33, 34s
Year: 2001

In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

In vitro pharmacological profile of CHF 5407, a potent, long-acting and selective muscarinic M3 receptor antagonist
Source: Eur Respir J 2007; 30: Suppl. 51, 25s
Year: 2007

ErbB receptor regulation by dexamethasone in mouse type II epithelial cells
Source: Eur Respir J 2006; 28: 1117-1123
Year: 2006