Resolvin E3 reduces profibrotic factor production from macrophages leading to tissue homeostasis

M. Yatomi (Maebashi, Japan), Y. Koga (Maebashi, Japan), H. Saito (Maebashi, Japan), M. Sato (Maebashi, Japan), H. Tsurumaki (Maebashi, Japan), K. Hara (Maebashi, Japan), N. Sunaga (Maebashi, Japan), T. Maeno (Maebashi, Japan), H. Ikeda (Sapporo, Japan), H. Fukuda (Nagasaki, Japan), S. Arai (Sapporo, Japan), K. Fujiwara (Sapporo, Japan), S. Shuto (Sapporo, Japan), T. Hisada (Maebashi, Japan)

Source: Virtual Congress 2020 – Mechanistic insight into lung injury and repair
Session: Mechanistic insight into lung injury and repair
Session type: E-poster session
Number: 558
Disease area: Interstitial lung diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Yatomi (Maebashi, Japan), Y. Koga (Maebashi, Japan), H. Saito (Maebashi, Japan), M. Sato (Maebashi, Japan), H. Tsurumaki (Maebashi, Japan), K. Hara (Maebashi, Japan), N. Sunaga (Maebashi, Japan), T. Maeno (Maebashi, Japan), H. Ikeda (Sapporo, Japan), H. Fukuda (Nagasaki, Japan), S. Arai (Sapporo, Japan), K. Fujiwara (Sapporo, Japan), S. Shuto (Sapporo, Japan), T. Hisada (Maebashi, Japan). Resolvin E3 reduces profibrotic factor production from macrophages leading to tissue homeostasis. 558

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Resolvin E3 dampens asthmatic inflammation in a murine model through IL-23 pathway
Source: International Congress 2019 – Revealing novel asthma immunopathology endotypes
Year: 2019



Arginine levels regulate pro-inflammatory mediator responses by lung epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 554s
Year: 2005

TGFβ overproduction in asthma reduces the epithelial repair by down-regulating the leptin/leptin receptor pathway
Source: Eur Respir J 2007; 30: Suppl. 51, 59s
Year: 2007

Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases
Year: 2010

Aerobic training inhibits leukocytes production of oxidants, pro-inflammatory and pro-fibrotic factors reducing asthmatic phenotype
Source: Annual Congress 2012 - Cell culture and animal models of lung disease
Year: 2012


Adapalene abrogates erlotinib-induced skin disorder by regulating proinflammatory cytokine production from human epidermal cells
Source: International Congress 2018 – Lung cancer: personalised medicine
Year: 2018




Dimethylfumarate reduces growth factor- and cytokine-induced IL-6 release from human lung fibroblasts: role of (NF)-κB
Source: Annual Congress 2008 - Airway cell biology and immunology
Year: 2008

iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Statins suppress LPS-induced proinflammatory cytokine production from human bronchial epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 29s
Year: 2004

Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-α release from human alveolar macrophages
Source: Eur Respir J 2007; 29: 986-994
Year: 2007



Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016

Resolvin D1 attenuates lung inflammation in LPS induced-ALI partly through PPARγ/NF-κB pathway
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

N-acetyl cysteine inhibits IL-17-induced IL-8 production from human airway smooth muscle cells - a possible role for anti-oxidant treatment in chronic lung rejection?
Source: Eur Respir J 2003; 22: Suppl. 45, 202s
Year: 2003

PP216 – Glucocorticoids exacerbate TGFß1 mediated fibrotic signalling in lung fibroblasts by inhibition of metalloproteinase expression and activity
Source: ERS Lung Science Conference 2021
Year: 2021

Overexpression of CBP augments cigarette smoke-induced pro-inflammatory cytokine release in macrophages
Source: Eur Respir J 2005; 26: Suppl. 49, 105s
Year: 2005

Activation of TLR3 augments myofibroblasts differentiation and extracellular matrix production
Source: Annual Congress 2009 - Lung cell biology and immunology
Year: 2009



Collagen itself perpetuates fibrotic remodeling via its immune-stimulating role upon alveolar macrophages and CCL18 production
Source: Eur Respir J 2006; 28: Suppl. 50, 604s
Year: 2006

CCL5 (RANTES) inhibits TGF-β1-induced collagen production in human bronchial epithelial cells by action of Smad protein
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009

Composition of the cellular matrix, nutrition, and hypoxia modulate the secretion and activation of collagenases and their inhibitors in human lung cells
Source: Eur Respir J 2001; 18: Suppl. 33, 244s
Year: 2001