Type II conventional dendritic cells of asthmatic patients with frequent exacerbations have an altered phenotype and frequency

Heleen Vroman, Irma Tindemans, Melanie Lukkes, Menno van Nimwegen, Geertje M. de Boer, Gerdien A. Tramper-Stranders, Gert-Jan Braunstahl, Rudi W. Hendriks, Mirjam Kool

Source: Eur Respir J, 55 (6) 1900859; 10.1183/13993003.00859-2019
Journal Issue: June
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Heleen Vroman, Irma Tindemans, Melanie Lukkes, Menno van Nimwegen, Geertje M. de Boer, Gerdien A. Tramper-Stranders, Gert-Jan Braunstahl, Rudi W. Hendriks, Mirjam Kool. Type II conventional dendritic cells of asthmatic patients with frequent exacerbations have an altered phenotype and frequency. Eur Respir J, 55 (6) 1900859; 10.1183/13993003.00859-2019

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Phenotype of dendritic cells (DCs) stimulated by microbial antigens in COPD patients with frequent and infrequent exacerbations.
Source: International Congress 2017 – Infection and exacerbation science
Year: 2017

Lung dendritic cells from chronic obstructive pulmonary disease patients induce type 1 T regulatory cells
Source: Annual Congress 2012 - Immunologic mechanisms in COPD and asthma
Year: 2012


The profile of dendritic cell and T cell response is related to the viral trigger in children with severe asthma exacerbation
Source: Annual Congress 2012 - Immunologic mechanisms in COPD and asthma
Year: 2012



Reduced numbers of circulating CD4+CD25highFOXP3+ regulatory T cells in patients with allergic asthma
Source: Annual Congress 2008 - Understanding airway inflammation
Year: 2008


The declined CD4+ CD25+Treg cells in patients with moderate to severe asthma associated with over-expressed Th2 response
Source: Annual Congress 2012 - Asthma and COPD: understanding through mechanisms
Year: 2012

Comparative characteristics of regulatory T cells populations between patients with bronchial asthma (BA) and COPD
Source: Annual Congress 2011 - T-cell subsets
Year: 2011

Changes in lymphocytes functional activity and type I/type II cytokines release in blood of allergic rhinitis patients
Source: Eur Respir J 2007; 30: Suppl. 51, 267s
Year: 2007

How cultured epithelial cells from asthma and COPD patients deal with pathogens: defective anti-rhinovirus responses in asthma
Source: Research Seminar 2008 - Host-pathogen interactions in the lung: implications for treatment of respiratory infections and inflammatory lung diseases
Year: 2008

Increased numbers of alveolar mast cells with an altered phenotype are linked to peripheral airway remodelling in patients with allergic asthma
Source: Annual Congress 2012 - Mechanisms of asthma
Year: 2012

Airway gene expression identifies subtypes of Type 2 inflammation in severe asthma
Source: Virtual Congress 2020 – Novel molecular markers and targets for asthma phenotypes
Year: 2020


Circulating respiratory syncytial virus-specific CD8+ T cells are present in a low frequency in healthy individuals and patients with COPD
Source: Eur Respir J 2004; 24: Suppl. 48, 686s
Year: 2004

Rhinovirus (RV)-induction of IL-15 in macrophages is dependent on type I IFNs, is deficient in asthma and related to exacerbation severity
Source: Annual Congress 2010 - Mechanisms of respiratory infections
Year: 2010

T-regulatory cells blood content in patients with asthma exacerbation
Source: Annual Congress 2011 - T-cell subsets
Year: 2011


Naturally occurring T-regulatory cells frequency in blood of patients with different levels of asthma control
Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2010

Omalizumab enhances the percentage of GARP cells in both regulatory and terminally differentiated effector Th cells in severe allergic asthmatics
Source: International Congress 2018 – Novel immunology-based therapies in asthma and COPD
Year: 2018



Altered phenotype of blood dendritic cells in patients with acute pneumonia
Source: Annual Congress 2011 - Phagocytes and dendritic cells
Year: 2011

A high probability of short-range interactions between fibrocytes and CD8+ T cells potentiates the inflammatory response in chronic obstructive pulmonary disease (COPD) lungs
Source: Virtual Congress 2020 – Host-microbe interactions and their influence on lung disease onset and severity
Year: 2020


Langerhans-type, but not interstitial-type dendritic cells accumulate in current smokers and COPD patients
Source: Annual Congress 2009 - Pathology and immunology of COPD
Year: 2009


Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid
Source: Annual Congress 2008 - Risk factors for asthma versus asthma control
Year: 2008

T regulatory cells decrease before asthma exacerbations
Source: Annual Congress 2008 - Understanding the mechanisms and the impact of severe asthma
Year: 2008