Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD

Alexander G. Mathioudakis, Andras Bikov, Philip Foden, Lies Lahousse, Guy Brusselle, Dave Singh, Jørgen Vestbo

Source: Eur Respir J, 55 (5) 1902119; 10.1183/13993003.02119-2019
Journal Issue: May
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Alexander G. Mathioudakis, Andras Bikov, Philip Foden, Lies Lahousse, Guy Brusselle, Dave Singh, Jørgen Vestbo. Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD. Eur Respir J, 55 (5) 1902119; 10.1183/13993003.02119-2019

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Blood eosinophils as a marker of response to inhaled corticosteroids in COPD
Source: Eur Respir J 2016; 47:1374-1382
Year: 2016



Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment
Source: Eur Respir J 2006; 27: 964-971
Year: 2006



Minimal effect of inhaled corticosteroids (ICS) on blood eosinophil count in steroid-naïve COPD patients
Source: International Congress 2015 – New data on established treatments for asthma, COPD and bronchiectasis
Year: 2015


Pulmonary function test changes after cessation of inhaled corticosteroid therapy in asthma patients
Source: Annual Congress 2012 - Aspects of clinical asthma
Year: 2012


Patients with COPD prescribed inhaled corticosteroid in primary care – Time for re-assessment based on exacerbation rate and blood eosinophils?
Source: Virtual Congress 2020 – Diagnosis and management of airways disease in primary care
Year: 2020

Assessment of maximal airway response before and after inhaled corticosteriod treatment in new diagnosed asthma patients
Source: Annual Congress 2007 - Improving asthma therapy - new findings in established and experimental treatment modalities
Year: 2007


Cytokines concentrations in induced sputum of mild COPD patients. Correlation to clinical response to inhaled corticosteroids
Source: Eur Respir J 2002; 20: Suppl. 38, 309s
Year: 2002

High sputum eosinophils are associated with better response to inhaled corticosteroids in asthmatic patients
Source: Eur Respir J 2002; 20: Suppl. 38, 113s
Year: 2002

Suppression of FENO with observed inhaled corticosteroid therapy in severe asthma: is it a useful test in clinical practice?
Source: ERJ Open Res, 5 (4) 00123-2019; 10.1183/23120541.00123-2019
Year: 2019



Monitoring of inflammatory changes in patients with bronchial asthma before and after oral corticosteroid treatment
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008


Lung function changes over time following withdrawal of inhaled corticosteroids in patients with severe COPD
Source: Eur Respir J 2016; 47: 651-654
Year: 2016


Clinically important deteriorations in COPD as a measure of response to dual and mono bronchodilator therapy with and without inhaled corticosteroids
Source: International Congress 2015 – New data on established treatments for COPD
Year: 2015


Association between blood eosinophil count and exacerbation risk in patients with asthma receiving medium- or high-dosage inhaled corticosteroids
Source: International Congress 2017 – Biomarker-based asthma control
Year: 2017


The interrelationship of the inflammatory markers in blood and sputum of stable COPD patients before and after treatment with inhaled steroids and N-acetylcysteine
Source: Eur Respir J 2003; 22: Suppl. 45, 281s
Year: 2003

Smoking, sputum cell counts, diffusion capacity and hyperinflation predict beneficial effects of long-term inhaled corticosteroids (ICS) on FEV1-decline in patients with mild-to-moderate COPD
Source: Annual Congress 2010 - COPD: management
Year: 2010

Low adherence to inhaled corticosteroids/long-acting ß2-agonists and biologic treatment in severe asthmatics
Source: ERJ Open Res, 6 (2) 00017-2020; 10.1183/23120541.00017-2020
Year: 2020



Does adherence to ICS/LABA therapy affect response to mepolizumab in the treatment of severe asthma?
Source: International Congress 2019 – Real-world experience of monoclonal antibodies in asthma
Year: 2019

A treatment algorithm adjusting oral corticosteroid using blood eosinophils reduces exacerbations and improves asthma control, in difficult asthmatics
Source: International Congress 2016 – Systemic biomarkers
Year: 2016

Reducing the dose of inhaled corticosteroids (ICS) under therapy with montelukast in stable asthma: effects on lung function and inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 261s
Year: 2001

Blood eosinophils do not predict inhaled budesonide response in bronchiectasis
Source: Eur Respir J, 56 (3) 2002210; 10.1183/13993003.02210-2020
Year: 2020