Antifibrotic effects of Lck inhibition on bleomycin-induced pulmonary fibrosis in mice

K. Kagawa (Tokushima, Japan), K. Koyama (Tokushima, Japan), S. Sato (Tokushima, Japan), N. Takahashi (Tokushima, Japan), H. Nishimura (Tokushima, Japan), N. Naito (Tokushima, Japan), H. Kawano (Tokushima, Japan), Y. Toyoda (Tokushima, Japan), Y. Nishioka (Tokushima, Japan)

Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Session: Translational aspects of idiopathic pulmonary fibrosis
Session type: Poster Discussion
Number: 5372
Disease area: Interstitial lung diseases, Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Kagawa (Tokushima, Japan), K. Koyama (Tokushima, Japan), S. Sato (Tokushima, Japan), N. Takahashi (Tokushima, Japan), H. Nishimura (Tokushima, Japan), N. Naito (Tokushima, Japan), H. Kawano (Tokushima, Japan), Y. Toyoda (Tokushima, Japan), Y. Nishioka (Tokushima, Japan). Antifibrotic effects of Lck inhibition on bleomycin-induced pulmonary fibrosis in mice. 5372

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Anti-fibrotic effect of telmisartan on bleomycin-induced lung fibrosis in mice
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008

Metformin attenuates bleomycin-induced pulmonary fibrosis in mice via IGF-1 suppression
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018

Effect of NF-?B inhibitor IMD-1041 on BLM-induced pulmonary fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017


The effect of curcumin on bleomycin-induced pulmonary fibrosis in rats
Source: Eur Respir J 2006; 28: Suppl. 50, 827s
Year: 2006

Effect of fasudil on the bleomycin-induced pulmonary fibrosis and hypertension in mice
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms
Year: 2012



Anti-inflammatory and anti-fibrotic effects of sirolimus in bleomycin-induced pulmonary fibrosis in rats
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010

HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012

The CDK4/6 inhibitor, palbociclib intensifies pulmonary inflammation in bleomycin-induced lung fibrosis
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


Ghrelin protects against bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017


Effect of nintedanib on silica-induced lung inflammation and fibrosis in mice
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012


The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in rats
Source: Eur Respir J 2002; 20: Suppl. 38, 487s
Year: 2002

17(R)-resolvin D1 attenuates bleomycin-induced lung fibrosis in mice
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013


The role of expression of TLR 4 in bleomycin-induced pulmonary fibrosis in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013


Expression of TGF-β and TGFβ receptors in bleomycin-induced pulmonary fibrosis of rats
Source: Eur Respir J 2002; 20: Suppl. 38, 312s
Year: 2002

The PDE4 inhibitor roflumilast reduced bleomycin-induced pulmonary fibrotic and vascular remodeling in mice in vivo
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008

The novel oligonucleotide therapeutics PK-7010 for TGF-ß1 ameliorates bleomycin-induced pulmonary fibrosis in mice
Source: Virtual Congress 2020 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2020


Inhibition of the Arp2/3 complex inhibits lung myofibroblast differentiation in vitro and attenuates bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

The effect of interferon-γ on bleomycin-induced alveolitis and pulmonary fibrosis in rats
Source: Eur Respir J 2005; 26: Suppl. 49, 81s
Year: 2005

Time course of bleomycin-induced pulmonary fibrosis and the antifibrotic effect of losartan
Source: Annual Congress 2007 - Mechanisms of injury and repair in fibrotic, idiopathic or infectious lung disease
Year: 2007


Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice
Source: Eur Respir J 2005; 25: 708-714
Year: 2005