Role of adenylate kinase 4 as a new metabolic regulator of pulmonary artery smooth muscle cells under hypoxia

M. Wujak (Giessen, Germany), T. Wilke (Giessen, Germany), A. Weiss (Giessen, Germany), M. Brosien (Giessen, Germany), C. Wu (Giessen, Germany), R. Schermuly (Giessen, Germany), H. Ghofrani (Giessen, Germany), W. Seeger (Giessen, Germany), F. Grimminger (Giessen, Germany), O. Pak (Giessen, Germany), N. Weissmann (Giessen, Germany)

Source: International Congress 2019 – Pulmonary hypertension: novelties from the bench
Session: Pulmonary hypertension: novelties from the bench
Session type: Poster Discussion
Number: 5044
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Wujak (Giessen, Germany), T. Wilke (Giessen, Germany), A. Weiss (Giessen, Germany), M. Brosien (Giessen, Germany), C. Wu (Giessen, Germany), R. Schermuly (Giessen, Germany), H. Ghofrani (Giessen, Germany), W. Seeger (Giessen, Germany), F. Grimminger (Giessen, Germany), O. Pak (Giessen, Germany), N. Weissmann (Giessen, Germany). Role of adenylate kinase 4 as a new metabolic regulator of pulmonary artery smooth muscle cells under hypoxia. 5044

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Endothelin-1 downregulates BMP signaling in pulmonary artery smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012

Endothelin-1 inhibits TASK-1 in human pulmonary artery smooth muscle cells via phospholipase C-diacylglycerol-protein kinase C-pathway
Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Year: 2008


PKC inhibits BKCa channel activity in pulmonary arterial smooth muscle cells through multiple signaling pathways
Source: Eur Respir J 2006; 28: Suppl. 50, 159s
Year: 2006

Bosentan stimulates the expression of cell cycle inhibitor p27(kip1) in pulmonary artery smooth muscle cells (PASMC)
Source: Annual Congress 2007 - Animal and ex vivo models of airway inflammation
Year: 2007


Hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: possible mechanisms
Source: Eur Respir J 2004; 24: Suppl. 48, 561s
Year: 2004

Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells - role of hypoxia-inducible transcription factors
Source: Eur Respir J 2001; 18: Suppl. 33, 159s
Year: 2001

Proliferative hypoxic response of pulmonary artery smooth muscle cells: the fibroblasts role
Source: Eur Respir J 2007; 30: Suppl. 51, 510s
Year: 2007

miR 16 modulates human pulmonary artery smooth muscle cell phenotype
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and cell biology
Year: 2012

Antiproliferative effects of drugs affecting different signalling pathways on rat and human pulmonary artery smooth muscle cells
Source: International Congress 2015 – Pulmonary hypertension: rare and hereditary causes of PAH
Year: 2015

Mir-17 modulates smooth muscle cell markers, apoptosis and BMPR-II levels in human pulmonary artery smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Sildenafil modulates PDGF and Angiotensin II induced migration and proliferation in human pulmonary artery smooth muscle cells (PA-SMC)
Source: Eur Respir J 2002; 20: Suppl. 38, 227s
Year: 2002

MAP kinase phosphatase 1 mediates glucocorticoid inhibition of CD38 expression in human airway smooth muscle
Source: Annual Congress 2008 - Basic science in asthma and COPD II
Year: 2008

Role of Ca2+-dependent protein kinases and protein phosphatase in the effect of urotensin II on the rat airway smooth muscle cells proliferation
Source: Eur Respir J 2004; 24: Suppl. 48, 227s
Year: 2004

Mitophagy plays an important role in hypoxia-induced pulmonary artery smooth muscle cell proliferation
Source: Virtual Congress 2020 – Experimental approaches to pulmonary hypertension
Year: 2020

Phosphodiesterase-type 3 inhibitor potentiates cAMP generation and antiproliferative effects of treprostinil in pulmonary arterial smooth muscle cells from patients with pulmonary hypertension
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010


Increased p130Cas activity induces smooth muscle cell proliferation and migration in idiopathic pulmonary arterial hypertension
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011


The effect of ASK1 inhibition on hypoxia-induced pulmonary artery fibroblast activation and associated paracrine effects on vascular smooth muscle cells
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

PDGF and Src tyrosine kinases in pulmonary arterial smooth muscle cells: Effects of dasatinib and nilotinib on pulmonary vascular remodeling
Source: Annual Congress 2011 - Treatments for pulmonary hypertension in human and experimental models
Year: 2011

Caspase-1 triggers smooth muscle cell proliferation in hypoxic pulmonary hypertension
Source: International Congress 2019 – Pulmonary hypertension: novelties from the bench
Year: 2019


LSC - 2018 - Pulmonary vascular remodeling mediated by ADORA2B in pulmonary artery smooth muscle cells
Source: International Congress 2018 – Pathobiology of pulmonary hypertension
Year: 2018