Safety, tolerability, pharmacokinetics and pharmacodynamics after repeated once or twice daily RVT-1201, a TPH inhibitor for treatment of PAH

S. Wring (Durham, United States of America), J. Rurka (Durham, United States of America), K. Crizer (Durham, United States of America), M. Palacios (Durham, United States of America), M. Snyder (Durham, United States of America), L. Keller (Durham, United States of America), P. Evans (Nottingham, United Kingdom), D. Carpenter (Durham, United States of America)

Source: International Congress 2019 – Pulmonary hypertension: clinical
Session: Pulmonary hypertension: clinical
Session type: Thematic Poster
Number: 4748
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Wring (Durham, United States of America), J. Rurka (Durham, United States of America), K. Crizer (Durham, United States of America), M. Palacios (Durham, United States of America), M. Snyder (Durham, United States of America), L. Keller (Durham, United States of America), P. Evans (Nottingham, United Kingdom), D. Carpenter (Durham, United States of America). Safety, tolerability, pharmacokinetics and pharmacodynamics after repeated once or twice daily RVT-1201, a TPH inhibitor for treatment of PAH. 4748

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Safety, tolerability and pharmacokinetics (PK) of repeated doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist, in healthy adults
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

Safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of GSK573719 inhalation powder in healthy subjects
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD7594 after single and multiple ascending inhaled doses in healthy Japanese males
Source: International Congress 2017 – COPD management
Year: 2017

Safety, tolerability and pharmacokinetics (PK) of AZD8154 (a selective PI3K?d inhibitor) after single ascending inhaled doses in healthy volunteers
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

The effects of multiple dosing of ketoconazole on the pharmacokinetics of a single dose ambrisentan
Source: Annual Congress 2008 - Pulmonary hypertension II
Year: 2008

Safety and pharmacokinetics of nintedanib plus sildenafil in the INSTAGE trial
Source: International Congress 2019 – Treatment and prognosis of idiopathic interstitial pneumonia
Year: 2019


Safety, pharmacokinetics, and pharmacodynamics of TD-8236, an inhaled pan-JAK inhibitor, following single- and multiple-ascending doses in healthy volunteers and mild asthmatics
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Safety, tolerability and pharmacokinetics of a new inhaled once-daily phosphodiesterase (PDE) 4 inhibitor in healthy volunteers
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

Dose escalation study in healthy male subjects to investigate safety, tolerability and systemic exposure of orally inhaled single-doses of AP301
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Roflumilast and sildenafil in healthy male volunteers: Single-dose pharmacokinetic interactions, safety and tolerability
Source: Annual Congress 2010 - Drug delivery and pharmacokinetics II
Year: 2010

The safety, tolerability, pharmacodynamics and pharmacokinetics of inhaled fluticasone furoate (FF) and vilanterol (VI) are unaffected by administration in combination
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Safety, immunogenicity and pharmacokinetics (PK) of a 120 mg/kg/week dose of alpha1-proteinase inhibitor in alpha1-antitrypsin deficiency
Source: Annual Congress 2013 –COPD drugs: new findings
Year: 2013


Comparison of the pharmacokinetic, pharmacodynamic, and safety profiles of three different formulations of intravenous epoprostenol sodium
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Safety, pharmacokinetics (PK) and pharmacodynamics (PD) of single doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist (LAMA), in patients with COPD
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Fevipiprant (QAW039) demonstrates safety, tolerability and consistent PK at high oral doses
Source: International Congress 2017 – Asthma: mechanisms and treatment
Year: 2017


High oral absolute bioavailability of roflumilast, a new, orally active, once daily PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

A comparative study of the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of salmeterol HFA and CFC MDI inhalers in healthy subjects
Source: Eur Respir J 2004; 24: Suppl. 48, 582s
Year: 2004

Lung function, pharmacokinetics, and tolerability of indacaterol maleate and acetate in asthma patients
Source: International Congress 2019 – Clinical studies of asthma treatments
Year: 2019


Evaluation of safety, tolerability, pharmacokinetics, and food effect of Danirixin oral tablets in Japanese elderly healthy subjects
Source: International Congress 2018 – Integrating pharmacological and non-pharmacological management in COPD: are we there yet?
Year: 2018




Safety and tolerability of the novel very long acting β2-agonist Carmoterol given as a 2μg qd dose; 8 days comparison with formoterol and placebo in patients with persistent asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 665s
Year: 2006