Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF.

T. Yoshikawa (Sapporo, Japan), M. Otsuka (Sapporo, Japan), K. Ikeda (Sapporo, Japan), Y. Mori (Sapporo, Japan), Y. Umeda (Sapporo, Japan), H. Nishikiori (Sapporo, Japan), S. Miyajima (Sapporo, Japan), M. Takahashi (Sapporo, Japan), K. Kuronuma (Sapporo, Japan), H. Chiba (Sapporo, Japan), H. Takahashi (Sapporo, Japan)

Source: International Congress 2019 – Biomarkers of idiopathic interstitial pneumonia
Session: Biomarkers of idiopathic interstitial pneumonia
Session type: Thematic Poster
Number: 4704
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Yoshikawa (Sapporo, Japan), M. Otsuka (Sapporo, Japan), K. Ikeda (Sapporo, Japan), Y. Mori (Sapporo, Japan), Y. Umeda (Sapporo, Japan), H. Nishikiori (Sapporo, Japan), S. Miyajima (Sapporo, Japan), M. Takahashi (Sapporo, Japan), K. Kuronuma (Sapporo, Japan), H. Chiba (Sapporo, Japan), H. Takahashi (Sapporo, Japan). Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF.. 4704

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Serum surfactant protein D (SP-D) is a lung derived biomarker for COPD that is responsive to treatment with oral corticosteroids
Source: Annual Congress 2008 - Biomarkers and disease assessment in COPD
Year: 2008


Plasma surfactant protein D (SP-D) and nutritive status in patients with COPD
Source: Annual Congress 2013 –COPD treatment and others
Year: 2013

Human napsin a is a useful serum marker of interstitial lung disease, compared to KL-6, and surfactant protein-D
Source: Annual Congress 2009 - Bronchoalveolar lavage and phenotyping in diffuse parenchymal lung disease
Year: 2009

Serum concentrations of KL-6 in patients with IPF and lung cancer and serial measurements of KL-6 in IPF patients treated with antifibrotic therapy
Source: Virtual Congress 2021 – Biomarkers and e-health in idiopathic interstitial pneumonia
Year: 2021


Comparative study of CC16, KL-6 and SP-D as serum markers in sarcoid patients
Source: Eur Respir J 2002; 20: Suppl. 38, 173s
Year: 2002

Surfactant protein D as a potential serum marker of pulmonary emphysema
Source: Annual Congress 2011 - Smoking-related disorders and smoking prevention
Year: 2011

The effect of a novel anti-inflammatory agent (ODSH) on C-reactive protein in patients with an acute exacerbation of COPD
Source: Annual Congress 2009 - Acute lung injury and biomarkers
Year: 2009


Serum KL-6, SP-D and MMP-2 as diagnostic biomarkers in asbestosis and silicosis
Source: International Congress 2017 – Silicosis has not gone away
Year: 2017




Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone
Source: International Congress 2017 – IPF: from the bench to the bedside
Year: 2017

Plasma biomarker assay and the immuno-modulatory effect of erythromycin in COPD
Source: Annual Congress 2009 - Biomarkers, comorbidities and prognosis of COPD
Year: 2009

Bio-markers (KL-6, SP-D and SP-A) in drug-induced pneumonitis
Source: Eur Respir J 2002; 20: Suppl. 38, 59s
Year: 2002

Differences in the immunolocalization of surfactant protein (SP)-A, SP-D and KL-6 in pulmonary alveolar proteinosis
Source: Annual Congress 2008 - Miscellaneous aspects of interstitial lung disease
Year: 2008


PP231 – Released mediators in ex vivo 3D-model of lung fibrosis correspond to elevated serum biomarkers in IPF
Source: ERS Lung Science Conference 2021
Year: 2021

Released mediators in ex vivo 3D-model of lung fibrosis correspond to elevated serum biomarkers in IPF
Source: Virtual Congress 2021 – Genetics and translational aspects of idiopathic pulmonary fibrosis
Year: 2021



Elevated serum IL-8: a biomarker indicating exacerbation-prone COPD
Source: International Congress 2017 – COPD biomarkers
Year: 2017

High level of serum SP-D with normal range of KL-6 predicts a good prognosis of patients with fibrotic changes on HRCT
Source: Annual Congress 2010 - Biomarkers in diffuse parenchymal lung disease
Year: 2010

KL-6 is a useful serum biomarker for early detection of interstitial lung disease
Source: Annual Congress 2012 - Diffuse parenchymal lung disease pathogenesis, biomarkers, therapy and new entities
Year: 2012


PP102 – A serum biomarker reflecting human neutrophil elastase degraded calprotectin is elevated in COPD and IPF
Source: ERS Lung Science Conference 2021
Year: 2021

The Gender-Age-Physiology (GAP) Index enhanced with KL-6 serum level for predicting disease progression in interstitial lung diseases (ILD).
Source: Virtual Congress 2020 – Predictive markers of progression in connective tissue disease-associated interstitial lung disease and hypersensitivity pneumonitis
Year: 2020


CHIT1 is a novel therapeutic target in idiopathic pulmonary fibrosis (IPF): anti-fibrotic efficacy of OATD-01, a potent and selective chitinase inhibitor in the mouse model of pulmonary fibrosis
Source: International Congress 2018 – Progress in basic and translational research on idiopathic interstitial pneumonias
Year: 2018