Prevotella genera abundance in bronchial brush samples differentiates COPD from health and is associated with gene expression

M. Yavari Ramsheh (Leicester, United Kingdom), G. Thun (Barcelona, Spain), A. Esteve Codina (Barcelona, Spain), K. Haldar (Leicester, United Kingdom), M. Barer (Leicester, United Kingdom), I. Gut (Barcelona, Spain), L. Ziegler-Heitbrock (Gauting, Germany), D. Singh (Manchester, United Kingdom), C. Brightling (Leicester, United Kingdom)

Source: International Congress 2019 – Research and innovation in airway diseases
Session: Research and innovation in airway diseases
Session type: Thematic Poster
Number: 4262
Disease area: Airway diseases, Respiratory infections

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Yavari Ramsheh (Leicester, United Kingdom), G. Thun (Barcelona, Spain), A. Esteve Codina (Barcelona, Spain), K. Haldar (Leicester, United Kingdom), M. Barer (Leicester, United Kingdom), I. Gut (Barcelona, Spain), L. Ziegler-Heitbrock (Gauting, Germany), D. Singh (Manchester, United Kingdom), C. Brightling (Leicester, United Kingdom). Prevotella genera abundance in bronchial brush samples differentiates COPD from health and is associated with gene expression. 4262

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A nasal gene expression profile differentiates individuals with and without COPD and overlaps bronchial gene expression
Source: International Congress 2017 – Rare and common genetic variants of common and rare airway diseases
Year: 2017


COPD bronchial brush microbiome association with lung function and bronchial gene expression
Source: Virtual Congress 2020 – Host-microbe interactions and their influence on lung disease onset and severity
Year: 2020


Changes in the lower airway bacterial community of from adult non-CF bronchiectasis population are significantly associated with exacerbations and the presence of Heamophilus influenza
Source: Annual Congress 2012 - Management of severe respiratory infections
Year: 2012

Characterisation and mRNA expression analysis of the bronchial hyperresponsiveness susceptibility gene protocadherin-1 in asthma patients
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009

The commensal bacterium Rothia mucilaginosa has anti-inflammatory properties in vitro and in vivo, and negatively correlates with sputum pro-inflammatory markers in chronic airway disease.
Source: Virtual Congress 2021 – Emerging new mechanisms of chronic lung disease
Year: 2021


Oral presentation: A comparative analysis of bacterial phylotypes of the lung microbiota of healthy, IPF and transplanted lungs
Source: Lung Science Conference 2013 - Early origins and mechanisms of chronic lung disease
Year: 2013

MicroRNA profiling in bronchial biopsies identifies altered expression in asthma and high levels of allergen-modulated epithelial microRNAs
Source: Virtual Congress 2021 – Early manifestations of chronic respiratory disease: zooming in at the epithelial barrier
Year: 2021



Differential gene expression in primary bronchial epithelial cells from COPD patients and control subjects. Evaluation by means of a cDNA array for cytokines and cytokine related genes
Source: Eur Respir J 2002; 20: Suppl. 38, 483s
Year: 2002

Spontaneous sputum production as a marker of bacterial colonisation in stable COPD
Source: Annual Congress 2005 - Acute and chronic infections in COPD
Year: 2005


Distinct epithelial phenotypes in child allergic respiratory disease are revealed by gene expression profiling
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009

Expression of selected surface markers on macrophages in induced sputum from patients with COPD
Source: Eur Respir J 2003; 22: Suppl. 45, 436s
Year: 2003

Lower airway bacterial colonization patterns and species-specific interactions in COPD
Source: International Congress 2018 – Epidemiology of COPD : from exarcebations and comorbidities to asthma-COPD overlap syndrome (ACOS)
Year: 2018

Expression of MIC-A molecules in bronchial epithelium of humans with and without current bacterial infection
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


The detection of free-living H. influenzae in the airways of patients with COPD
Source: International Congress 2015 – The relevance of diagnostic and monitoring tools in clinical practice
Year: 2015


Longitudinal analysis of airway epithelium of COPD subjects reveals unique inflammatory gene networks up-regulated over time
Source: Annual Congress 2012 - COPD inflammation and genes
Year: 2012


Clara cell secretory protein and its mRNA expression in induced sputum of acute bacterial exacerbations of COPD
Source: Eur Respir J 2002; 20: Suppl. 38, 543s
Year: 2002

Relationship between COPD characteristics and airway bacterial load measured using 16S qPCR
Source: International Congress 2015 – Notable abstracts in exacerbations, mechanisms and biomarkers in COPD
Year: 2015


Investigation and functional enrichment analysis of the human gene interaction network with common gram-negative respiratory pathogens predicts possible association with lung adenocarcinoma.
Source: International Congress 2019 – Crosstalk in chronic pulmonary diseases
Year: 2019

Relationship between a detection of anaerobes in the lung and poor oral hygiene; using the bacterial floral analysis of 16S rRNA gene
Source: International Congress 2019 – The microbiome: novel data across respiratory diseases
Year: 2019



Nasal NO concentrations and colonization of lower airways with P. aeruginosa are associated with variants in the neuronal NO synthase (NOS1) gene in CF patients
Source: Eur Respir J 2001; 18: Suppl. 33, 8s
Year: 2001