Calcium-sensing receptor (CaSR) drives lung ECM remodelling and fibrosis in murine asthma models and in ageing mice

R. Bruce (Cardiff, United Kingdom), P. Huang (Cardiff, United Kingdom), P. Yarova (Cardiff, United Kingdom), M. Schepelmann (Cardiff, United Kingdom), M. Schepelmann (Vienna, Austria), K. Wolffs (Cardiff, United Kingdom), B. Mansfield (Cardiff, United Kingdom), W. Ford (Cardiff, United Kingdom), E. Kidd (Cardiff, United Kingdom), W. Chang (San FRancisco, United States of America), R. Ecker (Vienna, Austria), R. Nica (Vienna, Austria), S. Ying (Beijing, China), P. Kemp (Cardiff, United Kingdom), D. Riccardi (Cardiff, United Kingdom)

Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Session: Airway inflammation: pharmacological mechanisms and novel targets
Session type: Thematic Poster
Number: 4213
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
R. Bruce (Cardiff, United Kingdom), P. Huang (Cardiff, United Kingdom), P. Yarova (Cardiff, United Kingdom), M. Schepelmann (Cardiff, United Kingdom), M. Schepelmann (Vienna, Austria), K. Wolffs (Cardiff, United Kingdom), B. Mansfield (Cardiff, United Kingdom), W. Ford (Cardiff, United Kingdom), E. Kidd (Cardiff, United Kingdom), W. Chang (San FRancisco, United States of America), R. Ecker (Vienna, Austria), R. Nica (Vienna, Austria), S. Ying (Beijing, China), P. Kemp (Cardiff, United Kingdom), D. Riccardi (Cardiff, United Kingdom). Calcium-sensing receptor (CaSR) drives lung ECM remodelling and fibrosis in murine asthma models and in ageing mice. 4213

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The epidermal growth factor receptor mediates allergic airway remodelling in the rat
Source: Eur Respir J 2008; 32: 1213-1223
Year: 2008



Osteopontin blockade prevents fibrosis in a murine chronic model of allergic airway disease
Source: Eur Respir J 2007; 30: Suppl. 51, 60s
Year: 2007

Chemokine receptors in a regulation of interstitial lung fibrosis and inflammation
Source: Annual Congress 2008 - Miscellaneous aspects of interstitial lung disease
Year: 2008


Haemophilus influenzae (NTHi) up-regulates acute inflammation in human lung tissue and causes downregulation of transforming growth factor-beta (TGF-beta) – A possible role of NTHi in remodeling processes in human lung tissue
Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease
Year: 2010

Activation of Fas receptor impairs alveolar epithelial function in mouse lungs
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

Effects of ciclesonide (CIC) on human adult lung fibroblasts functions involved in airway inflammation and remodeling
Source: Eur Respir J 2006; 28: Suppl. 50, 101s
Year: 2006

Expression and activity of bradykinin B2 receptor (B2R) in human airway fibroblast (HAFbs): a role in asthma remodeling
Source: Eur Respir J 2006; 28: Suppl. 50, 748s
Year: 2006

Elevated integrin ?5 expression in idiopathic pulmonary fibrosis (IPF) derived fibroblasts is linked to paracrine TNF-a signaling
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

Preserved compliance and reduced inflammation after activation of peroxisome proliferator-activated receptor (PPAR)a in a murine model of acute lung injury
Source: Annual Congress 2006 - Novel pathogenic aspects of acute lung injury and acute respiratory distress syndrome (ARDS)
Year: 2006


Specific ligand for the innate repair receptor, ARA290, attenuates pulmonary hypertension in an elastase-induced murine model of emphysema
Source: International Congress 2017 – Experimental PH
Year: 2017


RhoA signalling influences cyclin D1 expression and associated fibroblast turnover: implications for idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006


Toll like receptor 4 activation upregulates miR-181b attenuating pulmonary fibrosis via targeting TGFBR1
Source: International Congress 2015 – Latest news on miRNAs in pulmonary research
Year: 2015



Decreased Smad7 expression in the airways of a mouse model of chronic asthma
Source: Annual Congress 2004 - Animal models of allergic airway disease
Year: 2004


Naftopidil, a selective a1 adrenoceptor antagonist, inhibits the growth of lung fibroblasts and attenuates bleomycin-induced lung fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

PAR-2 agonists induce TGF-beta and EMT leading to lung fibrosis
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice
Source: Eur Respir J 2008; 32: 426-436
Year: 2008



Extracellular ATP triggers and maintains airway inflammation in human and murine models of asthma by activating dendritic cells
Source: Annual Congress 2008 - New mechanisms in the pathogenesis of asthma and its response to treatment
Year: 2008


Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation
Source: Annual Congress 2006 - Cellular immunology in asthma pathogenesis
Year: 2006


Soluble biglycan promotes ovalbumin induced airway inflammation by modulating dendritic cell function in mice
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019


Surface enolase-1 mediated cell migration and lung fibrosis in bleomycin-induced mice
Source: Virtual Congress 2021 – Translational and other aspects of idiopathic interstitial pneumonia
Year: 2021