A novel TRPA1 antagonist inhibits ovalbumin-induced bronchoconstriction in guinea pig models
M. van den Berg (Groningen, Netherlands), S. Nijboer-Brinksma (Groningen, Netherlands), S. Bos (Groningen, Netherlands), M. Van Den Berge (Groningen, Netherlands), D. Lamb (Biberach an der Riss, Germany), M. Van Faassen (Groningen, Netherlands), I. Kema (Groningen, Netherlands), R. Gosens (Groningen, Netherlands), L. Kistemaker (Groningen, Netherlands)
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Disease area: Airway diseases
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
M. van den Berg (Groningen, Netherlands), S. Nijboer-Brinksma (Groningen, Netherlands), S. Bos (Groningen, Netherlands), M. Van Den Berge (Groningen, Netherlands), D. Lamb (Biberach an der Riss, Germany), M. Van Faassen (Groningen, Netherlands), I. Kema (Groningen, Netherlands), R. Gosens (Groningen, Netherlands), L. Kistemaker (Groningen, Netherlands). A novel TRPA1 antagonist inhibits ovalbumin-induced bronchoconstriction in guinea pig models. 4210
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Late asthmatic response is modulated by TRPA1 antagonists in ovalbumin-induced bronchoconstriction in anaesthetized guinea pigs Source: Annual Congress 2012 - New drug targets and pre-clinical models for respiratory diseases Year: 2012
Alpha-1L, but not alpha-1H, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo Source: Eur Respir J 2001; 18: Suppl. 33, 104s Year: 2001
Selective PDE inhibitors in modulation of cough reflex and bronchoconstriction in healthy and ovalbumin-sensitized guinea pigs Source: Annual Congress 2010 - Models of airways disease Year: 2010
Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology Year: 2007
Effect of thromboxane A2 (TXA2 ) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs Source: Eur Respir J 2001; 18: Suppl. 33, 264s Year: 2001
Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in the airway remodeling induced by chronic airway inflammation in guinea pigs Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II Year: 2008
AWD 12-281, a new PDE4-inhibitor, suppresses allergen-induced [DCquote]early phase“ bronchoconstriction in sensitized guinea pigs Source: Eur Respir J 2003; 22: Suppl. 45, 107s Year: 2003
Efficacy of the TRPV1 antagonist SB-705498 in an MRI guinea pig model of rhinitis Source: Annual Congress 2011 - Translational models of airway disease Year: 2011
Budesonide-induced decrease of IL-5 production does not affect allergen-induced bronchoconstriction or AHR in a novel guinea pig asthma model Source: International Congress 2019 – Novel insights from in vitro and in vivo models of lung disease Year: 2019
PGD2 induces constriction of the peripheral guinea pig lung via the TP receptor Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD Year: 2008
CS-003, a novel triple neurokinin receptor antagonist, inhibits symptoms of respiratory diseases models in guinea pigs Source: Eur Respir J 2006; 28: Suppl. 50, 664s Year: 2006
CHF6366: characterisation of the bronchoprotective effect of a novel MABA compound in the experimental bronchospasm model in anaesthetised guinea pigs Source: International Congress 2017 – Novel studies on bronchodilators and cough Year: 2017
Endogenous PGE2 contributes to antigen-induced contractions of guinea pig trachea Source: Annual Congress 2011 - Models of disease and drug actions Year: 2011
Antagonism by reproterol of adenosine-mediated tension responses in isolated guinea pig trachea Source: Eur Respir J 2003; 22: Suppl. 45, 106s Year: 2003
Effect of H+K+ATPase inhibitors on airway cough hypersensitivity induced by allergic inflammation in guinea pigs Source: Eur Respir J 2003; 22: Suppl. 45, 106s Year: 2003
The cannabinoid receptor agonist, WIN 55,212-2, inhibits antigen-induced plasma extravasation in guinea pig airways Source: Annual Congress 2010 - Models of airways disease Year: 2010
Effect of chronic ovalbumin sensitization on bronchoconstriction induced by hyperventilation in guinea pigs Source: Eur Respir J 2001; 18: Suppl. 33, 103s Year: 2001
The β-adrenoceptor antagonist propranolol induced Ca2+ mobilisation and enhanced contractile responses in guinea pig airways, in vitro Source: Eur Respir J 2002; 20: Suppl. 38, 190s Year: 2002
Bronchoconstriction induced by prostaglandin D2 (PGD2 ) in guinea pig lung is enhanced by selective COX-2 inhibition Source: Eur Respir J 2006; 28: Suppl. 50, 759s Year: 2006
Icaritin inhibited ovalbumin-induced airway inflammation in murine model Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma Year: 2020