Intranasal treatment with the mitochondria-targeted slow hydrogen sulfide releasing donor AP39 prevents inflammation-induced airway hyperreactivity in mice

Y. Karaman-Kutluay (Ankara, Turkey), Y. Kaya-Yasar (Trabzon, Turkey), T. Bozkurt (Ankara, Turkey), S. Celik Onder (Ankara, Turkey), I. Sahin-Erdemli (Ankara, Turkey)

Source: International Congress 2019 – Advances in asthma pharmacology
Session: Advances in asthma pharmacology
Session type: Poster Discussion
Number: 3879
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Karaman-Kutluay (Ankara, Turkey), Y. Kaya-Yasar (Trabzon, Turkey), T. Bozkurt (Ankara, Turkey), S. Celik Onder (Ankara, Turkey), I. Sahin-Erdemli (Ankara, Turkey). Intranasal treatment with the mitochondria-targeted slow hydrogen sulfide releasing donor AP39 prevents inflammation-induced airway hyperreactivity in mice. 3879

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Hydrogen sulphide donors prevent hyperreactivity of mice tracheas in an in vitro lipopolysaccharide-induced inflammation model
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018




In vivo blockade of CTLA-4 counteracts inhalation tolerance and leads to development of allergic airway inflammation in mice repeatedly exposed to aerosolized ovalbumin
Source: Eur Respir J 2004; 24: Suppl. 48, 6s
Year: 2004

Inhalation of hydrogen gas attenuate airway inflammation and oxidative stress in allergic asthmatic mice
Source: International Congress 2017 – Techniques to treat asthma
Year: 2017

A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

Overexpression of peroxiredoxin 6 protect mice from ovalbumin-induced airway inflammation and hypersecretion of MUC5AC by reducing ROS levels
Source: Annual Congress 2011 - Animal models of airway inflammation
Year: 2011


Inhaled cationic salts modulate macrophage function to reduce inflammation during LPS induced lung injury
Source: Annual Congress 2012 - Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD
Year: 2012

Airway hyperresponsiveness to histamine induced by repetitive intraperitoneal injection of lipopolysacharide and the involvement of nitric oxide generation in guinea pigs
Source: Eur Respir J 2005; 26: Suppl. 49, 367s
Year: 2005

Intratracheal instillation of antigen-pulsed macrophages mediates repression of allergic airway inflammation
Source: Eur Respir J 2003; 22: Suppl. 45, 483s
Year: 2003

Endogenous hydrogen sulfide reduces airway hyperresponsiveness and airway inflammation in a rat model of chronic obstructive pulmonary disease
Source: Annual Congress 2009 - COPD: from biomarker profiling to clinical assessment
Year: 2009


Ovalbumin challenge causes epithelial damage in murine airways by a substance P mediated generation of reactive oxygen species
Source: Eur Respir J 2002; 20: Suppl. 38, 94s
Year: 2002

iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response
Source: Eur Respir J 2002; 20: 609-616
Year: 2002



Regulated lung-specific overexpression of nitric oxide induces airway hyperresponsiveness in mice
Source: Eur Respir J 2002; 20: Suppl. 38, 568s
Year: 2002

LSC 2011 Abstract: Combined nasal exposure to sodium hypochlorite and ovalbumin induces airway hyperreactivity in mice through activation of the TRPA1 channel and mast cells
Source: Annual Congress 2011 - Environmental exposure and disease mechanisms
Year: 2011


Endotoxin interferes with allergy-induced airway inflammation in mice
Source: Eur Respir J 2004; 24: Suppl. 48, 348s
Year: 2004

Dexamethasone reduces lung inflammation induced by alveolar stretch in mice
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

Endotoxin potentiates allergic airway inflammation in ovalbumin sensitised and challenged mice
Source: Annual Congress 2009 - Animal models of airways inflammation
Year: 2009

Chronic nitric oxide inhibition modulates inflammatory cells apoptosis induced by dexamethasone in guinea pigs with chronic airway inflammation
Source: Eur Respir J 2005; 26: Suppl. 49, 368s
Year: 2005

Inhalation of nano-scaled titianium dioxide particles aggravates airway inflammation in allergen-challenged mice
Source: Annual Congress 2011 - Environmental exposure and disease mechanisms
Year: 2011


Azithromycin prevents airway epithelial barrier dysfunction induced by sulphur dioxide inhalation
Source: Virtual Congress 2020 – Cutting edge science: novel molecules and mechanisms of airway diseases
Year: 2020




Modulation of chronic airway inflammation in guinea pigs by oral tolerance: effects in lung mechanics, cellular infiltration and nitric oxide production
Source: Eur Respir J 2002; 20: Suppl. 38, 382s
Year: 2002