Generation and activation of myeloid derived suppressor cells using prostaglandin E2 and EP receptor agonists in vitro

C. Van Geffen (Tübingen, Germany), S. Beer-Hammera (Tübingen, Germany), B. Nürnberg (Tübingen, Germany), S. Kolahian (Tübingen, Germany)

Source: International Congress 2019 – Advances in asthma pharmacology
Session: Advances in asthma pharmacology
Session type: Poster Discussion
Number: 3871
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Van Geffen (Tübingen, Germany), S. Beer-Hammera (Tübingen, Germany), B. Nürnberg (Tübingen, Germany), S. Kolahian (Tübingen, Germany). Generation and activation of myeloid derived suppressor cells using prostaglandin E2 and EP receptor agonists in vitro. 3871

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 100s
Year: 2003

EP4 agonist increases myeloid derived suppressor cells activity and reduces airway inflammatory events in a murine model of asthma
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020


Effects on cytokine expression in human plasmacytoid dendritic cells by prostaglandin I2 analogs
Source: Annual Congress 2009 - Translational models of lung disease
Year: 2009


Prostaglandin E2 suppresses the function of human group 2 innate lymphoid cells
Source: International Congress 2018 – Roles of innate lymphoid cells in asthma
Year: 2018


The up-regulation of cysteinyl-leukotriene receptors on T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 395s
Year: 2003

Fevipiprant inhibits prostaglandin D2 mediated activation of group 2 innate lymphoid cells (ILC2s)
Source: International Congress 2018 – Studies on the mechanisms underlying airway disease
Year: 2018


Fevipiprant inhibits eosinophil activation induced by multiple metabolites of prostaglandin D2
Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses
Year: 2019


Down-regulation of allergic reactions by stimulation of prostaglandin E receptor EP3 subtype
Source: Annual Congress 2004 - Insights into asthma and COPD
Year: 2004


Synergistic action of formoterol on budesonide-generated decrease of proteoglycan production by activated lung fibroblasts is mediated via β-adrenergic receptor and is dependent on glucocorticoid receptor
Source: Eur Respir J 2004; 24: Suppl. 48, 345s
Year: 2004

The inducible kinin B1 receptor stimulates human airway fibroblast (Fb) proliferation
Source: Eur Respir J 2004; 24: Suppl. 48, 37s
Year: 2004

COX-1 driven biosynthesis of PGD2 during activation of human mast cells prevents formation of other prostanoids
Source: Virtual Congress 2020 – Novel molecular markers and targets for asthma phenotypes
Year: 2020


Dexamethasone induces the expression of β2-adrenergic receptors in Human macrophage/monocytic U937 cells
Source: Eur Respir J 2003; 22: Suppl. 45, 452s
Year: 2003

Liver-X-receptor agonists, but not dexamethasone, inhibit leukotriene production from human white blood cells pretreated with GM-CSF and activated with fMLP
Source: Annual Congress 2007 - New treatments for asthma and COPD - experimental evidence
Year: 2007


Effects of retinoic acid receptor selective agonists on human nasal epithelial cell differentiation
Source: Eur Respir J 2001; 18: Suppl. 33, 77s
Year: 2001

Serotonin (5-hydroxytryptamine) modulates cytokine and chemokine production in lipopolysaccharide-primed human monocytes via stimulation of different 5-HT receptor subtypes
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-α release from human alveolar macrophages
Source: Eur Respir J 2007; 29: 986-994
Year: 2007



Muscarinic receptors mediate up-regulation of endothelin-1 expression in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

TNF-α inhibits human eosinophil apoptosis by activating p55 receptor and NF-κB
Source: Eur Respir J 2001; 18: Suppl. 33, 162s
Year: 2001

5-Hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of human dendritic cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Glucocorticoid potency correlates with transcriptional induction of a glucocorticoid regulated gene in human monocytes
Source: Eur Respir J 2005; 26: Suppl. 49, 369s
Year: 2005