Late Breaking Abstract - Multiple ascending dose study of the inhaled IL-4Ra antagonist, AZD1402/PRS-060, in mild asthmatics demonstrates robust FeNO reduction and a promising clinical profile for the treatment of asthma I. Bruns (Boston, United States of America), M. Fitzgerald (Boston, United States of America), G. Mensing (Boston, United States of America), M. Tsung (Boston, United States of America), K. Pardali (Gothenburg, Sweden), P. Gardiner (Gothenburg, Sweden), D. Keeling (Gothenburg, Sweden), L. Axelsson (Gothenburg, Sweden), M. Olsson (Gothenburg, Sweden), C. Ghobadi (Gothenburg, Sweden), O. Walsh (Melbourne, Australia), K. Mclendon (Herston, Australia), N. Farinola (Adelaide, Australia), L. Hatchuel (Nedlands, Australia), D. Close (Cambridge, United Kingdom)
Source: International Congress 2019 – Asthma treatment: novel insights from clinical studies
Session: Asthma treatment: novel insights from clinical studies Session type: Poster DiscussionNumber: 3709
Disease area: Airway diseasesRating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
I. Bruns (Boston, United States of America), M. Fitzgerald (Boston, United States of America), G. Mensing (Boston, United States of America), M. Tsung (Boston, United States of America), K. Pardali (Gothenburg, Sweden), P. Gardiner (Gothenburg, Sweden), D. Keeling (Gothenburg, Sweden), L. Axelsson (Gothenburg, Sweden), M. Olsson (Gothenburg, Sweden), C. Ghobadi (Gothenburg, Sweden), O. Walsh (Melbourne, Australia), K. Mclendon (Herston, Australia), N. Farinola (Adelaide, Australia), L. Hatchuel (Nedlands, Australia), D. Close (Cambridge, United Kingdom). Late Breaking Abstract - Multiple ascending dose study of the inhaled IL-4Ra antagonist, AZD1402/PRS-060, in mild asthmatics demonstrates robust FeNO reduction and a promising clinical profile for the treatment of asthma. 3709
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
A randomized phase 3 study of reslizumab efficacy in relation to blood eosinophil levels in patients with moderate to severe asthma Source: International Congress 2014 – Clinical trials of drugs for respiratory diseases Year: 2014
A predictive model of failed stepping-down of inhaled corticosteroids in adult asthmatics Source: International Congress 2016 – Notable abstracts on clinical problems related to asthma Year: 2016
High or standard initial dose of budesonide to control mild-to-moderate asthma? Source: Eur Respir J 2001; 17: 856-862 Year: 2001
The effects of early intervention with inhaled budesonide on lung function in mild persistent asthma: results from the START study Source: Eur Respir J 2003; 22: Suppl. 45, 34s Year: 2003
Late Breaking Abstract - Can a self-management plan, which includes a four-fold increase in inhaled corticosteroid dose, reduce severe asthma exacerbations: a randomised, pragmatic trial. Source: International Congress 2017 – Late-breaking findings in asthma and COPD Year: 2017
The impact of stepwise withdrawal of inhaled corticosteroids on lung function in COPD patients receiving dual bronchodilation: WISDOM study Source: International Congress 2014 – New clinical evidence for asthma and COPD treatments Year: 2014
Effect of QVA149 on lung function in the subgroup of patients with a history of exacerbations in the previous year and baseline ICS use from the SHINE study Source: International Congress 2014 – Asthma and COPD devices and treatments Year: 2014
Individual and differential treatment responses to once-daily long acting bronchodilators, glycopirronium and indacaterol, and combination of both drugs in the patients with moderate or severe COPD Source: International Congress 2014 – New clinical evidence for asthma and COPD treatments Year: 2014
Suppression of F ENO with observed inhaled corticosteroid therapy in severe asthma: is it a useful test in clinical practice? Source: ERJ Open Res, 5 (4) 00123-2019; 10.1183/23120541.00123-2019 Year: 2019
A double blind placebo controlled study to assess the effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients using novel biomarkers Source: International Congress 2014 – Clinical trials of drugs for respiratory diseases Year: 2014
A pilot study for markers which can reflect asthmatic activity before and after reduction of inhaled corticosteroids Source: Annual Congress 2013 –Assessment of airway inflammation by exhaled gases Year: 2013
Late Breaking Abstract - Phase 2 trial evaluating the effects of dexpramipexole on blood eosinophils, lung function, and airway biomarkers in eosinophilic asthma Source: Virtual Congress 2021 – ALERT: Asthma in adult, in children and ILDs Year: 2021
Blood eosinophil dose response to oral corticosteroids in a population of patients with severe asthma Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma Year: 2016
Baseline exhaled NO in relation to asthma control improvement after increased dose of inhaled steroids – A real-life study Source: Annual Congress 2013 –Assessment of airway inflammation by exhaled gases Year: 2013
Monitoring asthma and adjusting the inhaled steroid dose: is there a better way? Source: Annual Congress 2005 - Are we ready for "inflammometry"? The role of eNO in asthma management Year: 2005
A treatment algorithm adjusting oral corticosteroid using blood eosinophils reduces exacerbations and improves asthma control, in difficult asthmatics Source: International Congress 2016 – Systemic biomarkers Year: 2016
Late Breaking Abstract: Inhaled pitrakinra, an IL-4/IL-13 antagonist, reduced exacerbations in patients with eosinophilic asthma Source: Annual Congress 2010 - Treatment options for asthma Year: 2010
Late Breaking Abstract - An assessment of potential predictive biomarkers for the treatment of severe eosinophilic asthma with CRTH2 antagonists Source: International Congress 2019 – Asthma treatment: novel insights from clinical studies Year: 2019
Efficacy of low dose theophylline in patient with bronchial asthma - anti-inflammatory effect Source: Eur Respir J 2003; 22: Suppl. 45, 102s Year: 2003
The concept study: comparative influence of two treatment strategies on airway response to AMP Source: Annual Congress 2005 - Combination therapy for asthma. Which, why and how? Year: 2005