Dysregulated balance of lung macrophage populations in idiopathic pulmonary fibrosis revealed by single-cell RNA seq: an unstable “ménage-à-trois”

Bernard Mari, Bruno Crestani

Source: Eur Respir J, 54 (2) 1901229; 10.1183/13993003.01229-2019
Journal Issue: August
Disease area: Interstitial lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Bernard Mari, Bruno Crestani. Dysregulated balance of lung macrophage populations in idiopathic pulmonary fibrosis revealed by single-cell RNA seq: an unstable “ménage-à-trois”. Eur Respir J, 54 (2) 1901229; 10.1183/13993003.01229-2019

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Distinct gene expression profiles of cultured stromal cells from the patients with idiopathic pulmonary fibrosis and lung adenocarcinoma
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Cytokine profiles in idiopathic pulmonary fibrosis suggest an important role for TGF-β and IL-10
Source: Eur Respir J 2003; 22: 69-76
Year: 2003



The global microRNA profile of idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Lung cancer, idiopathic pulmonary fibrosis and sarcoidosis: the genetic approach
Year: 2010

Expression of mRNA of selected inflammatory markers in BALf cells from patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF)
Source: International Congress 2017 – IPF: from the bench to the bedside
Year: 2017

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Analysis of cellular components of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis and pulmonary sarcoidosis: focus on lymphocyte and macrophage subpopulations
Source: Annual Congress 2008 - Allergy and immunology of asthma and beyond
Year: 2008

Altered expression of long non-coding RNA in sputum and blood during pulmonary exacerbation in cystic fibrosis
Source: Virtual Congress 2021 – Novel insights into the pathogenesis of chronic lung diseases
Year: 2021


Expression of macrophage migration inhibitory factor in patients with idiopathic pulmonary fibrosis
Source: International Congress 2015 – Interstitial lung diseases II
Year: 2015

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and human donor lungs
Source: Annual Congress 2008 - Management of idiopathic pulmonary fibrosis: what can we learn from the pathophysiology?
Year: 2008

Altered expression of adhesion molecules in circulating neutrophils of patients with idiopathic pulmonary fibrosis
Source: Eur Respir J 2002; 20: Suppl. 38, 479s
Year: 2002

Differential expression of stromal cell derived factor-1/CXC chemokine receptor 4 (SDF-1/CXCL12 – CXCR4) biological axis between idiopathic pulmonary fibrosis and interstitial pneumonia associated with collagen vascular disease: a bronchoalveolar la
Source: Annual Congress 2008 - Interstitial lung disease in systemic and vascular disorders
Year: 2008

Expression profiling of Th17 associated molecules in bronchoalveolar cells from patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011

Cykine/receptor inflammatory profile in different types of idiopathic intestitial pneumonias (IIPs). Key role of Fas Ligand recruvation in idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2010 - Biomarkers in diffuse parenchymal lung disease
Year: 2010


Relationship between MIF and cellular pattern in BAL of patients with sarcoidosis, systemic sclerosis, idiopathic pulmonary fibrosis
Source: Eur Respir J 2003; 22: Suppl. 45, 377s
Year: 2003

Decreased BCL-2 expression in alveolar macrophages of patients with idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Biomarkers in diffuse parenchymal lung disease
Year: 2010


The role of IL-10 receptors in aberrant homeostatic control of TNF-α in idiopathic pulmonary fibrosis (IPF)
Source: Eur Respir J 2002; 20: Suppl. 38, 599s
Year: 2002

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP)
Source: Annual Congress 2013 –Connective tissue disease and interstitial lung disease
Year: 2013

The role of extracellular vesicles in phenotypic alteration of lung cells in pulmonary fibrosis
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013

Exhausted T lymphocytes in chronic obstructive pulmonary disease: single-cell analysis of human lung tissue
Source: Virtual Congress 2021 – Emerging new mechanisms of chronic lung disease
Year: 2021


MiR-185/AKT and miR-29a/collagen 1a pathways are activated in IPF alveolar macrophages
Source: International Congress 2016 – IPF: from pathogenesis to treatment II
Year: 2016