Dysregulation of the “inflammatory reflex” with abnormal neurohumoral activation may contribute to proinflammatory activity driving the progression of COPD

Fabrizio Ricci, Per Wollmer, Gunnar Engström, Artur Fedorowski, Viktor Hamrefors

Source: Eur Respir J, 51 (6) 1800806; 10.1183/13993003.00806-2018
Journal Issue: June
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Fabrizio Ricci, Per Wollmer, Gunnar Engström, Artur Fedorowski, Viktor Hamrefors. Dysregulation of the “inflammatory reflex” with abnormal neurohumoral activation may contribute to proinflammatory activity driving the progression of COPD. Eur Respir J, 51 (6) 1800806; 10.1183/13993003.00806-2018

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Impaired lung function is associated with systemic inflammation and macrophage activation
Source: Eur Respir J 2015; 45: 557-559
Year: 2015


Adrenergic regulation of the lung inflammatory response
Source: Annual Congress 2008 - Novel trends in functional genomics and molecular pathology of neoplastic and non-neoplastic lung diseases
Year: 2008


The proinflammatory cytokine is important in determining the severity of asthma enhancing the inflammatory process
Source: Eur Respir J 2004; 24: Suppl. 48, 592s
Year: 2004

Nlrc5 is involved in allergic airway inflammation and negatively regulates inflammatory signaling pathway via TLR2/NF-?B.
Source: International Congress 2018 – Translational models of the immunopathology that underlies airway obstructive diseases
Year: 2018

WNT-4 regulates pro-inflammatory responses driven by epithelial-mesenchymal cross-talk
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

Gut microbial modulation attenuates emphysema development by suppressing inflammation and apoptosis
Source: Virtual Congress 2020 – New insight into the immunology of asthma and COPD
Year: 2020


Breathing disorders and survival during inflammation associated with severely hypoxia depends from prostaglandin-mediated pathway.
Source: International Congress 2018 – Preclinical and clinical studies of critical illness
Year: 2018


A major inflammatory cytokine TNF-a inhibits the ventilatory response to hypoxia
Source: International Congress 2018 – Triggers of acute lung injury: mechanical ventilation and oxygen levels
Year: 2018


Amifostine reduces lipopolysaccharide-induced lung dysfunction via suppression of redox-sensitive inflammatory signaling
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008


Activation of proteolytic mechanisms in response to inflammatory stimuli: a possible role in the development of the aleolocapillary barrier damage
Source: Eur Respir J 2003; 22: Suppl. 45, 458s
Year: 2003

The role of pro-inflammatory cytokine activation in perioperative lung injury
Source: Annual Congress 2004 - Mechanisms and biomarkers of ischaemia-reperfusion-induced lung injury: lessons learnt from lung transplantation
Year: 2004

Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016

Dynamic of proinflammatory cytokines system and nonspecific markers of inflammation in patients with COPD before and after treatment with broncholitics
Source: Eur Respir J 2006; 28: Suppl. 50, 38s
Year: 2006

Antifibrotics modulate B lymphocyte activation resulting in a decrease of the profibrotic milieu in patients with pulmonary fibrosis
Source: International Congress 2019 – Translational aspects of idiopathic interstitial pneumonia
Year: 2019


iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Role of cytokines in regulation of inflammatory and protective reactions in progression of pulmonary MDR tuberculosis
Source: Annual Congress 2007 - New methods to diagnose tuberculosis infection and disease and problems in tuberculosis care
Year: 2007


Circulating MDSC modulate IPF progression by orchestrating immunosuppressive and pro-fibrotic networks
Source: International Congress 2018 – Advanced profiling of immune cells in chronic lung diseases
Year: 2018

IL-33 blockade impacts mediators of persistence and exacerbation of chronic airway inflammation.
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018



ET-1 regulates pathological cell proliferation by ERK1/2 in a state of chronic inflammation
Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease
Year: 2010

Micro-RNA-125a/b target A20 and MAVS to promote inflammatory and impair antiviral responses in chronic obstructive pulmonary disease
Source: International Congress 2016 – Mechanisms of disease
Year: 2016