NTHi-induced inflammation activates the PD-1 immune checkpoint in the tumor microenvironment

F. Ritzmann (Homburg, Germany), G. Vella (Homburg, Germany), C. Herr (Homburg, Germany), R. Bals (Homburg, Germany), C. Beisswenger (Homburg, Germany)

Source: International Congress 2018 – Lung cancer: novel molecular markers and mechanisms
Session: Lung cancer: novel molecular markers and mechanisms
Session type: Oral Presentation
Number: 5378
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
F. Ritzmann (Homburg, Germany), G. Vella (Homburg, Germany), C. Herr (Homburg, Germany), R. Bals (Homburg, Germany), C. Beisswenger (Homburg, Germany). NTHi-induced inflammation activates the PD-1 immune checkpoint in the tumor microenvironment. 5378

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The PD-1 immune checkpoint promotes lung damage in murine models of COPD-like inflammation
Source: International Congress 2019 – Injury and repair: less is more
Year: 2019



Inhibition of osteopontin modulates tumor-stimulated immune response and suppresses mesothelioma progression
Source: Annual Congress 2012 - Biology and treatment of malignant pleural effusions
Year: 2012



Central role for phosphoinositide-3-kinase gamma/delta dependent signalling in eosinophilic pulmonary inflammation driven by innate lymphoid cells
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017

c-Met expression induction in immune cells modulates pulmonary fibrosis progression
Source: Virtual Congress 2020 – Physiological and cellular mechanisms affecting pulmonary pathologies
Year: 2020

Over-expression of SIGIRR attenuates TLR 4,5,9-mediated immune responses in human airway epithelial cells
Source: Annual Congress 2009 - Mechanisms of infection: what's new?
Year: 2009

IL-4 induces Th2 cells to resist the IL-27 counterregulation by downregulating STAT1 and STAT2 phosphorylation
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012

Nlrc5 is involved in allergic airway inflammation and negatively regulates inflammatory signaling pathway via TLR2/NF-?B.
Source: International Congress 2018 – Translational models of the immunopathology that underlies airway obstructive diseases
Year: 2018

A pathogen-activated innate homing pathway that instructs allergic inflammation
Source: Annual Congress 2007 - Regulation of allergic airway inflammation in animal models of asthma
Year: 2007


Tim-3 regulates Tregs’ ability to resolve the inflammation and proliferation of acute lung injury by polarizing M2c macrophages
Source: International Congress 2017 – Anti-inflammatory and pro-repair mediators in acute lung injury
Year: 2017

Stimulation of NOD1 induces RIP2, TAK1 and p38 MAPK dependent pro-inflammatory signalling in human lung microvascular endothelial cells
Source: Annual Congress 2011 - Mechanisms of acute lung injury and mesenchymal cell treatment
Year: 2011


Amifostine reduces lipopolysaccharide-induced lung dysfunction via suppression of redox-sensitive inflammatory signaling
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008


Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice
Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring
Year: 2007


The role of innate immune cells in inflammation
Source: International Congress 2015 – Resolving inflammation
Year: 2015



ET-1 regulates pathological cell proliferation by ERK1/2 in a state of chronic inflammation
Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease
Year: 2010

PPAR-gamma modulates allergic inflammation through upregulation of PTEN
Source: Eur Respir J 2005; 26: Suppl. 49, 25s
Year: 2005

A T cell-specific inhibitor of NF-kappaB and AP-1 suppresses lung fibrosis in mice
Source: Eur Respir J 2004; 24: Suppl. 48, 101s
Year: 2004

Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016

Rhinovirus-induced proinflammatory cascade in bronchial epithelial cells requires xanthine-oxidase system activation
Source: Annual Congress 2008 - New diagnostic methods in viral and atypical infections
Year: 2008


The molecular mechanisms of lymphocyte apoptosis disregulation at Th1- and Th2- cytokine disbalance
Source: Annual Congress 2011 - Lung development and neoplasia
Year: 2011

GM-CSF and CSF-1 co-regulate lung inflammation and ERMP12+ progenitor recruitment during immune responses to LPS in vivo
Source: Eur Respir J 2006; 28: Suppl. 50, 300s
Year: 2006