Smooth-muscle-derived WNT-5A drives allergen-induced remodelling and Th2 type inflammation

T. Koopmans (Groningen, Netherlands), L. Hesse (Groningen, Netherlands), M. Nawijn (Groningen, Netherlands), M. Menzen (Groningen, Netherlands), R. Smits (Rotterdam, Netherlands), E. Bakker (Utrecht, Netherlands), J. Vonk (Groningen, Netherlands), M. Van Den Berge (Groningen, Netherlands), G. Koppelman (Groningen, Netherlands), V. Guryev (Groningen, Netherlands), R. Gosens (Groningen, Netherlands)

Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Koopmans (Groningen, Netherlands), L. Hesse (Groningen, Netherlands), M. Nawijn (Groningen, Netherlands), M. Menzen (Groningen, Netherlands), R. Smits (Rotterdam, Netherlands), E. Bakker (Utrecht, Netherlands), J. Vonk (Groningen, Netherlands), M. Van Den Berge (Groningen, Netherlands), G. Koppelman (Groningen, Netherlands), V. Guryev (Groningen, Netherlands), R. Gosens (Groningen, Netherlands). Smooth-muscle-derived WNT-5A drives allergen-induced remodelling and Th2 type inflammation. 5256

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Interferon-γ-pretreated dendritic cells induced dual Th1 and Th2 responses and failed to prevent development of allergic airway inflammation
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

CD4 + T-helper cells engineered to produce IL-10 reverse allergen-induced airway hyperreactivity and inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 432s
Year: 2001

Different Th1, Th2, Th17 and Treg associated chemokine local pattern expression in lung in a murine model of allergic inflammation
Source: Annual Congress 2011 - T-cell subsets
Year: 2011


CCL6 produced by eosinophils drives allergic airway inflammation in mice
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation and remodelling
Source: Annual Congress 2007 - PG1 - Asthma: from bench to bedside
Year: 2007


Aerobic training decreases epithelial expression of Th2 cytokines in a murine model of allergic lung inflammation
Source: Annual Congress 2007 - Towards an understanding of asthma pathogenesis - novel in vitro assays and results from animal models
Year: 2007


TNF-α negatively modulates allergen-induced airway hyperresponsiveness through γδ T cells
Source: Eur Respir J 2002; 20: Suppl. 38, 27s
Year: 2002

High-level expression of PD-L1 by DC suppresses airway inflammation in OVA-induced allergic asthma
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

IL-4/IL-13 promote Th2-type inflammatory changes in airway smooth muscle and induce myofibroblast differentiation
Source: Eur Respir J 2005; 26: Suppl. 49, 224s
Year: 2005

A dual role of IL-6 signalling and STAT-3 activation on airway inflammation versus airway hyperresponsiveness in a murine model of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 568s
Year: 2002

Airway epithelial cell P2Y6R-Expression is up-regulated during acute and chronic allergic inflammation and contributes via modulating of CXC8 and IL-6 secretion to development of airway remodelling
Source: Annual Congress 2010 - Pre-clinical models of airways disease
Year: 2010



ADAM-8 metalloproteinase drives acute allergen-induced airway inflammation
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

4-1BBL/4-1BB costimulation alleviates airway inflammation by restoring Treg/Th17 balance in allergic asthma
Source: Annual Congress 2012 - Asthma and COPD: understanding through mechanisms
Year: 2012

The inflammation and the airway hyperresponsiveness in allergic asthma is inhibited by IL-10 dependent mechanism
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Role of IL-33 signaling in pollutant-induced allergic airway inflammation
Source: International Congress 2018 – Translational models of the immunopathology that underlies airway obstructive diseases
Year: 2018


Transgenic mice overexpressing IL-18 display increased IL-13 in the airways but no changes of the airway hyperresponsiveness in a murine model of late-phase asthma: evidence for a dual role of IL-18 on mucosal Th1/Th2 responses
Source: Eur Respir J 2002; 20: Suppl. 38, 1s
Year: 2002

Farm dust decreases Th2 driven allergic airway inflammation in mice: A role for airway TLR2 and TLR4?
Source: Annual Congress 2011 - T-cell subsets
Year: 2011


IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma
Source: Annual Congress 2012 - Asthma and COPD: understanding through mechanisms
Year: 2012

γδ T cells contribute to local and systemic B cell reactivity in allergic eosinophilic airway inflammation but without a major influence on the TH1/TH2 balance
Source: Eur Respir J 2002; 20: Suppl. 38, 568s
Year: 2002

ILC2s in allergic airway inflammation
Source: International Congress 2014 – Highlights from the Lung Science Conference 2014
Year: 2014