Novel cell types and altered cell states in asthma revealed by single-cell RNA sequencing of airway wall biopsies.

M. Nawijn (Groningen, Netherlands), O. Carpaij (Groningen, Netherlands), F. Vieira Braga (Cambridge, United Kingdom), M. Berg (Groningen, Netherlands), S. Brouwer (Groningen, Netherlands), G. Kar (Cambridge, United Kingdom), S. Teichmann (Cambridge, United Kingdom), M. Van Den Berge (Groningen, Netherlands)

Source: International Congress 2018 – A fresh view on airway differentiation and regeneration
Session: A fresh view on airway differentiation and regeneration
Session type: Oral Presentation
Number: 505
Disease area: Airway diseases

Congress or journal article abstractSlide presentationWebcast

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Nawijn (Groningen, Netherlands), O. Carpaij (Groningen, Netherlands), F. Vieira Braga (Cambridge, United Kingdom), M. Berg (Groningen, Netherlands), S. Brouwer (Groningen, Netherlands), G. Kar (Cambridge, United Kingdom), S. Teichmann (Cambridge, United Kingdom), M. Van Den Berge (Groningen, Netherlands). Novel cell types and altered cell states in asthma revealed by single-cell RNA sequencing of airway wall biopsies.. 505

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Single-cell RNA sequencing reveals novel cell differentiation dynamics in the human airway epithelium
Source: International Congress 2019 – The Human Lung Cell Atlas
Year: 2019


Microfluidic single cell analysis of microRNA levels in small airway epithelial cells and fibroblasts from COPD patients
Source: Virtual Congress 2021 – Early manifestations of chronic respiratory disease: zooming in at the epithelial barrier
Year: 2021



Single cell RNA analysis of cellular niche in normal and impaired late lung development
Source: Virtual Congress 2020 – Airway development in health and disease
Year: 2020




Cell type eQTL deconvolution of bronchial epithelium through integration of single cell and bulk RNA-seq
Source: Virtual Congress 2021 – Early manifestations of chronic respiratory disease: zooming in at the epithelial barrier
Year: 2021



Oligonucleotide microarray analysis demonstrates lung fibroblast to smooth muscle cell phenotypic switching in response to TGFβ1
Source: Eur Respir J 2001; 18: Suppl. 33, 162s
Year: 2001

High dimensional single cell analysis reveals unexpected immune cell types, and loss of motility and chemokine receptor expression of alveolar macrophages in chronic obstructive respiratory disease
Source: International Congress 2018 – Advanced profiling of immune cells in chronic lung diseases
Year: 2018



PP105 – Single-cell transcriptome analysis reveals an anomalous epithelial variation and ectopic inflammatory response in COPD
Source: ERS Lung Science Conference 2021
Year: 2021

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
Source: Eur Respir J, 56 (3) 2001123; 10.1183/13993003.01123-2020
Year: 2020



High-plex immunofluorescence single cell analysis of fibrotic murine lung on tissue microarrays
Source: Virtual Congress 2020 – Cellular involvement in lung injury
Year: 2020


Late Breaking Abstract - High-content phenotypic profiling reveals that IL-13 impairs planar cell polarity and directional mucus clearance in human airway tissue
Source: International Congress 2019 – Understanding lung disease: novel in vitro models
Year: 2019



Differential gene expression in primary bronchial epithelial cells from COPD patients and control subjects. Evaluation by means of a cDNA array for cytokines and cytokine related genes
Source: Eur Respir J 2002; 20: Suppl. 38, 483s
Year: 2002

A genomic approach to understanding epithelial cell function in COPD
Source: Annual Congress 2008 - “Omics” and systems biology: the promise of future disease understanding
Year: 2008


Identification of transcripts overexpressed during airway epithelium differentiation
Source: Eur Respir J 2008; 32: 121-128
Year: 2008



Exploring the molecular potential of bacterial lysates to reduce COVID-19 susceptibility of bronchial epithelial cells in vitro
Source: Virtual Congress 2021 – Pharmacology of airway diseases: clinical and laboratory studies
Year: 2021


Identifying the sputum and BALF cell subpopulation with somatic DNA alterations in COPD
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Lung adenocarcinoma subtypes based on expression of human airway basal cell genes
Source: Eur Respir J 2013; 42: 1332-1344
Year: 2013



Different stages of wound repair in differentiated human bronchial epithelial cells show altered microRNA expression
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015


Transcriptomic analyses reveal anti-viral responses of epithelial cells and multiple immune cell types in HRV infected human lung tissue
Source: International Congress 2017 – From microbiology to clinical work
Year: 2017

Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases
Source: Eur Respir J, 57 (6) 2003794; 10.1183/13993003.03794-2020
Year: 2021



Transcriptomic profiling of alveolar type 2 cells from mice expressing an ILD associated SFTPCI73T mutation supports their role in inflammatory cell recruitment and fibrotic lung remodeling.
Source: International Congress 2018 – Pulmonary fibrosis: from models to patients
Year: 2018