Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Disease area: Airway diseases



Rating:

Share or cite this content

Citations should be made in the following way:
K. E. Paschalaki, R. D. Starke, Y. Hu, N. Mercado, A. Margariti, V. G. Gorgoulis, A. M. Randi, P. J. Barnes (London, United Kingdom; Athens, Greece). Endothelial progenitor cells are dysfunctional in smokers and COPD patients due to increased DNA damage and senescence. Eur Respir J 2013; 42: Suppl. 57, 4861

Member's Comments

No comment yet.

Related content which might interest you: IL-17A is elevated in patients with COPD and contributes to airway remodeling by acting on fibroblasts Source: International Congress 2016 – What's new in biomarker analysis? Year: 2016 Epithelial to mesenchymal transition in basal progenitor epithelial cells cultured from smokers and COPD patients Source: International Congress 2015 – Airway remodelling: recent developments Year: 2015 DNA damage as a molecular link in the pathogenesis of COPD in smokers Source: Eur Respir J 2012; 39: 1368-1376 Year: 2012 Increased circulating fibrocytes and their capacity of proliferation and differentiation in clinically unstable patients with chronic obstructive pulmonary disease Source: Annual Congress 2013 –COPD: new markers of diseases Year: 2013 Involvement of mitochondrial fragmentation in cigarette smoke induced-bronchial epithelial cell senescence Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung Year: 2013 Myofibroblast expression in airways and alveoli is affected by smoking and COPD Source: Annual Congress 2013 –COPD: new markers of diseases Year: 2013 Involvement of ferroptosis in COPD pathogenesis Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis Year: 2016 Neutrophil numbers are decreased in bronchial biopsies from patients with COPD Source: Annual Congress 2013 –COPD: new markers of diseases Year: 2013 Blood outgrowth endothelial cells are senescent and dysfunctional in COPD due to increased DNA damage; implications for endothelial dysfunction Source: Annual Congress 2012 - Inflammatory mechanisms in COPD Year: 2012 Fibroblasts from IPF explanted lungs have mitochondrial dysfunction and short telomeres leading to an increased senescence phenotype Source: International Congress 2016 – IPF: from pathogenesis to treatment I Year: 2016 Pulmonary senescence in chronic obstructive pulmonary disease is primarily mediated by persistent DNA double strand breaks Source: Annual Congress 2013 –Tobacco use in different countries: crisis to disease Year: 2013 Cultured satellite cells as a model for the study of muscle dysfunction in COPD Source: Annual Congress 2013 –The best posters in exercise testing and physical inactivity Year: 2013 Cigarette smoke alters the EZH2/DAB2IP expression in bronchial epithelial cells. A risk factor for lung cancer in COPD patients Source: International Congress 2016 – Studies in airway cell biology Year: 2016 Parkin-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC) Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung Year: 2013 Functional comparison of bone-marrow derived mesenchymal stromal cells obtained from COPD patients and non-COPD controls Source: International Congress 2015 – Cellular and molecular mechanisms of COPD and emphysema Year: 2015 Aclidinium bromide reduces epithelial-mesenchymal transition of human COPD epithelial cells Source: Annual Congress 2013 –Translational studies in chronic lung diseases: from bedside to bench Year: 2013 Cigarette smoke impairs autophagic flux in bronchial epithelial cells Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung Year: 2013 Bone marrow-derived MSCs from patients with COPD have abnormal functional capacity Source: Annual Congress 2013 –Translational studies in chronic lung diseases: from bedside to bench Year: 2013 The transcription factor slug is increased in pulmonary artery endothelial cells of COPD patients Source: Annual Congress 2013 –Pulmonary circulation: basic science Year: 2013 Myeloid derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in COPD Source: International Congress 2016 – New signalling pathways in COPD Year: 2016