Maintenance of IRF1 by MAPK inhibition: A mechanism by which DUSP1 reduces glucocorticoid inhibition of CXCL10 Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action Year: 2016
AZD1402/PRS-060, an inhaled Anticalin® IL-4Ra antagonist, potently inhibits IL-4 induced functional effects in human whole blood, which can be employed translationally in clinical studies. Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control Year: 2018
Dexamethasone inhibits LPS-induced expression of human β-defensin-2 via down-regulation of TLR4 Source: Eur Respir J 2003; 22: Suppl. 45, 562s Year: 2003
Interleukin-12 receptor mRNA expression and corticosteroid depended eosinophil apoptosis in asthma Source: Eur Respir J 2003; 22: Suppl. 45, 223s Year: 2003
Inhibition of phosphodiesterase 4B enhances glucocorticoid-dependent gene transcription in human airway epithelial cells: Implications for the treatment of COPD Source: Annual Congress 2013 –New drugs in respiratory medicine Year: 2013
Synergistic action of formoterol on budesonide-generated decrease of proteoglycan production by activated lung fibroblasts is mediated via β-adrenergic receptor and is dependent on glucocorticoid receptor Source: Eur Respir J 2004; 24: Suppl. 48, 345s Year: 2004
Stimulation of IL-8 release in respiratory cell cultures by increasing IL1-beta concentrations: Effect of budesonide Source: Annual Congress 2013 –Asthma: new mechanisms and markers Year: 2013
cPLA2alpha inhibitor ASB14780 suppresses airway MMP-9 production and improves respiratory function in cigarette-smoke induced model Source: International Congress 2014 – Animal models in respiratory drug development Year: 2014
Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases Year: 2010
Resveratrol upregalates PTEN and inhibits MUC5AC expression in ovalbumin (OVA)-induced asthma model mice Source: International Congress 2016 – Preclinical pharmacology: drug targets and mechanisms of action Year: 2016
Endothelin receptor antagonists (ERAs) neutralize LPS-induced cytokine release from pulmonary vascular smooth muscle cells (PVSMCs) by down-regulation of CD14 Source: Annual Congress 2013 –Airway smooth muscle and cell biology Year: 2013
Inhibition of inflammatory gene expression by dexamethasone partly depends on the phosphatase, MKP-1 (DUSP1) Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine Year: 2013
IL-37 ameliorates experimental asthma by inhibiting IL-1 Source: International Congress 2018 – Novel immunology-based therapies in asthma and COPD Year: 2018
Formoterol enhances glucocorticoid receptor nuclear translocation in steroid-insensitive severe asthma Source: Eur Respir J 2004; 24: Suppl. 48, 250s Year: 2004
Interleukin-17 enhances epithelial IL-6 production solely by stabilizing IL-6 mRNA, which is reversed by microRNA16 Source: Eur Respir J 2007; 30: Suppl. 51, 212s Year: 2007
Synergistic suppression of human rhinovirus induced pro-inflammatory cytokines by B2 agonists and glucocorticoids Source: Annual Congress 2004 - Mechanisms and treatment of virus induced asthma exacerbations Year: 2004
Anti-inflammatory activity of β2-agonists in primary lung epithelial cells is independent of glucocorticoid receptor Source: Eur Respir J 2007; 30: 848-856 Year: 2007
Elevated CCL2 responses in COPD and attenuation by selective chemokine receptor antagonists Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease Year: 2015
Glucocorticoid potency correlates with transcriptional induction of a glucocorticoid regulated gene in human monocytes Source: Eur Respir J 2005; 26: Suppl. 49, 369s Year: 2005
Use of interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) contents in alveolar macrophages for estimation of inflammation activity in patients with different levels of asthma control Source: Annual Congress 2013 –Macrophages, mononuclear cells and viral infection Year: 2013