Does tumor necrosis factor-α (TNFα) protect immune cells from apoptosis in lower airways?

P. Kopinski, J. Soja, A. Szlubowski, M. Plato, B. Balicka, G. Pinis, J. Szczeklik, K. Sladek (Bydgoszcz, Krakow, Poland)

Source: Annual Congress 2007 - Considerations in the therapeutic approach of interstitial lung disease: oxidative stress and inflammation
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. Kopinski, J. Soja, A. Szlubowski, M. Plato, B. Balicka, G. Pinis, J. Szczeklik, K. Sladek (Bydgoszcz, Krakow, Poland). Does tumor necrosis factor-α (TNFα) protect immune cells from apoptosis in lower airways?. Eur Respir J 2007; 30: Suppl. 51, 777

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Resistance of BAL immune cells to apoptosis in interstitial lung diseases (ILD) with high local tumor necrosis factor-α (TNFα) levels as a possible consequence of common TNF receptor type 2 expression
Source: Annual Congress 2008 - Role of bronchoalveolar lavage in studying the pathophysiology of interstitial lung disease
Year: 2008


Fas Ligand (FasL) expressed on alveolar lymphocytes (AL) plays role in progression of interstitial lung diseases (ILD) but not in local induction of immune cells apoptosis
Source: Eur Respir J 2005; 26: Suppl. 49, 542s
Year: 2005

LSC Abstract – High mobility group box 1 modulates lung innate immunity by promoting wound healing and cytokine release in human bronchial epithelial cells
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

Upregulation of the production of TGF-β and IL-4 and downregulation of IL-6 by apoptotic human bronchial epithelial cells: possible role in regulation of epithelial repair following acute lung injury
Source: Eur Respir J 2001; 18: Suppl. 33, 477s
Year: 2001

Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction
Source: Eur Respir J 2012; 40: 424-435
Year: 2012



Low apoptosis rate as a reason of local immune cell accumulation in interstitial lung diseases (ILD). The role of cytokine network
Source: Eur Respir J 2006; 28: Suppl. 50, 826s
Year: 2006

Proinflammatory effects of interferon beta (IFNβ) in virally infected bronchial epithelial cell cultures
Source: Annual Congress 2009 - Viruses and respiratory infections: prevalence and mechanisms of infection
Year: 2009


Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis
Source: Eur Respir J 2013; 41: 683-694
Year: 2013



TD-0903, an inhaled JAK inhibitor in development for COVID-19, blocks ARDS-relevant hyperinflammation and lung injury in primary human immune and airway epithelial cells
Source: Virtual Congress 2021 – Emerging respiratory diseases: state-of-the-art studies of SARS-CoV-2 infection
Year: 2021



Anti-inflammatory effect of adenovirus-mediated IκBα overexpression in respiratory epithelial cells
Source: Eur Respir J 2001; 18: 801-809
Year: 2001



Alternaria fungal extracts disrupt the barrier function and induce secretion of inflammatory cytokines in airway epithelial cells
Source: Annual Congress 2010 - Epithelial cells: cell biology and role in lung disease
Year: 2010

Resistance of quiescent and proliferating airway epithelial cells to H2O2 challenge
Source: Eur Respir J 2007; 29: 633-642
Year: 2007



Interactions between neutrophils and NSCLC cells in vitro – effects on neutrophil inflammatory mediator generation and tumor cell proliferation
Source: Annual Congress 2010 - Pathology of lung cancer
Year: 2010

Role of interferon-γ in tumor necrosis factor-α-mediated increase of lung microvascular endothelial cells
Source: Annual Congress 2012 - Basic and translational studies in COPD
Year: 2012


Transforming growth factor beta (TGF-β) augments rhinovirus (RV) replication in primary bronchial epithelial cells (pbecs) through modulation of the innate immune response
Source: Annual Congress 2009 - Viruses and respiratory infections: prevalence and mechanisms of infection
Year: 2009


Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

Physiomer(R) reduces the chemokine interleukin-;8 production by activated human respiratory epithelial cells
Source: Eur Respir J 2001; 18: 661-666
Year: 2001



Primary bronchial epithelial cells from stable lung allografts induce the differentiation of monocytes into macrophage like cells
Source: Annual Congress 2008 - New insights and treatment options for bronchiolitis obliterans syndrome after lung transplantation
Year: 2008

N-acetylcysteine reduces tumor necrosis factor-α release by alveolar macrophages of interstitial lung disease in vitro
Source: Annual Congress 2007 - Considerations in the therapeutic approach of interstitial lung disease: oxidative stress and inflammation
Year: 2007


Azithromycin increases phagocytosis of apoptotic airway epithelial cells by alveolar macrophages in vitro
Source: Annual Congress 2005 - Cellular and molecular approaches to lung injury research
Year: 2005