Effects of a newly developed dual CysLT1 and CysLT2 receptor antagonist, ONO-RS-531, on antigen- and leukotriene D4-induced contractions of isolated human bronchi

T. Nabe, M. Fujita, Y. Yonetomi, T. Nakao, M. Fujii, K. Kawabata, K. Kishikawa, M. Horiba, S. Kohno (Kyoto, Osaka, Ogaki, Japan)

Source: Annual Congress 2005 - New perspectives in asthma treatment
Session: New perspectives in asthma treatment
Session type: Poster Discussion
Number: 1387
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Nabe, M. Fujita, Y. Yonetomi, T. Nakao, M. Fujii, K. Kawabata, K. Kishikawa, M. Horiba, S. Kohno (Kyoto, Osaka, Ogaki, Japan). Effects of a newly developed dual CysLT1 and CysLT2 receptor antagonist, ONO-RS-531, on antigen- and leukotriene D4-induced contractions of isolated human bronchi. Eur Respir J 2005; 26: Suppl. 49, 1387

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Expression of the cysteinyl leukotriene receptors cysLT1 and cysLT2 in the airway structural cells
Source: Eur Respir J 2005; 26: Suppl. 49, 346s
Year: 2005

Upregulation of cysteinyl leukotriene receptors CysLT1 and CysLT2 by TGF-β1 and LTE4 on human bronchial epithelial cells
Source: Annual Congress 2006 - Airway epithelial cells in inflammation
Year: 2006


Effect of AVE5883, a dual NK1/NK2 receptor antagonist, on airway responsiveness to neurokinin A in asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 219s
Year: 2004

The effects of a cysteinyl leukotriene receptor antagonist, pranlukast, on dendritic cell chemoattractants in the airways of subjects with asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 132s
Year: 2004

Effect of cysteinyl leukotriene receptor antagonist on airway wall remodeling
Source: Eur Respir J 2002; 20: Suppl. 38, 304s
Year: 2002

Effects of leukotriene receptor antagonists on airway mucus secretion
Source: Eur Respir J 2001; 18: Suppl. 33, 245s
Year: 2001

The CysLT1 receptor antagonist montelukast inhibits mast cell activation induced by inhaled leukotriene E4 in subjects with asthma
Source: International Congress 2016 – Clinical and molecular studies in asthma
Year: 2016


The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 100s
Year: 2003

One component of the antigen-induced contraction of the guinea-pig trachea is mediated by serotonin acting on 5-HT2A receptors
Source: Eur Respir J 2007; 30: Suppl. 51, 620s
Year: 2007

Antigen-induced airway hyperresponsiveness and eosinophilia in mice is inhibited by the endothelin receptor antagonist SB217242
Source: Eur Respir J 2001; 18: Suppl. 33, 349s
Year: 2001

Increased expression of the cysteinil leukotriene 1 receptor (CysLT1-R) in the bronchial epithelium of smokers
Source: Eur Respir J 2001; 18: Suppl. 33, 74s
Year: 2001

SCH 527123, a CXCR2 antagonist, inhibits ozone-induced airway neutrophilia in healthy subjects
Source: Annual Congress 2007 - New drugs for COPD
Year: 2007


Increased relaxation of immature airways to beta-2 agonists is related to the attenuated expression of postjunctional smooth muscle muscarinic M2 receptors
Source: Annual Congress 2004 - Understanding the complexity of how airways are regulated
Year: 2004


The triple neurokinin receptor antagonist CS-003 inhibits neurokinin A (NKA)-induced bronchoconstriction in patients with asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 415s
Year: 2003

The CysLT1 receptor antagonist montelukast blocks bronchoconstriction induced by inhaled leukotriene E4 in subjects with asthma
Source: International Congress 2015 – The immunology of allergic airway disease
Year: 2015

The cannabinoid receptor agonist, WIN 55,212-2, inhibits antigen-induced plasma extravasation in guinea pig airways
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407
Source: Eur Respir J 2007; 30: Suppl. 51, 26s
Year: 2007

Effect of thromboxane A2(TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 264s
Year: 2001

Inhibition of eosinophil migration by montelukast, a cysteinyl leukotriene receptor antagonist, through down regulation of plasmin activity
Source: Eur Respir J 2004; 24: Suppl. 48, 36s
Year: 2004

Cysteinyl leukotriene-induced upregulation of tenascin and laminin β2 chain in human bronchial epithelial cells is mediated by the CysLT1 receptor
Source: Eur Respir J 2007; 30: Suppl. 51, 217s
Year: 2007