Cystic fibrosis patients with ΔF508 mutation demonstrate local immune response of Th2 type

G. V. Shmarina, A. L. Pukhalsky, D. A. Pukhalskaya, N. V. Petrova, N. I. Kapranov (Moscow, Russian Federation)

Source: Annual Congress 2006 - From genes to outcome: a long distance
Session: From genes to outcome: a long distance
Session type: Thematic Poster Session
Number: 4117
Disease area: Paediatric lung diseases, Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. V. Shmarina, A. L. Pukhalsky, D. A. Pukhalskaya, N. V. Petrova, N. I. Kapranov (Moscow, Russian Federation). Cystic fibrosis patients with ΔF508 mutation demonstrate local immune response of Th2 type. Eur Respir J 2006; 28: Suppl. 50, 4117

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cystic fibrosis patients were incapable of excessive IL-10 production in response to antigen challenge
Source: Eur Respir J 2001; 18: Suppl. 33, 125s
Year: 2001

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease
Source: Eur Respir J, 57 (6) 1900716; 10.1183/13993003.00716-2019
Year: 2021



Lack of an exaggerated inflammatory response on virus infection in cystic fibrosis
Source: Eur Respir J 2012; 39: 297-304
Year: 2012



Disturbance of pro-inflammatory cytokine production in patients with cystic fibrosis lung disease
Source: Eur Respir J 2005; 26: Suppl. 49, 404s
Year: 2005

Disturbance of TGF-β-dependent T cell-mediated regulation in cystic fibrosis patients
Source: Eur Respir J 2006; 28: Suppl. 50, 484s
Year: 2006

Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis
Source: Annual Congress 2005 - Progresses in lung fibrosis
Year: 2005


Treg alterations lead to systemic and local immune deregulation in idiopathic pulmonary fibrosis and collagen vascular disease-associated interstitial pneumonia
Source: Annual Congress 2007 - Cell biology of asthma and COPD
Year: 2007


Dysregulation of systemic and local immune response in cystic fibrosis patients with chronic P. aeruginosa infection
Source: Eur Respir J 2004; 24: Suppl. 48, 385s
Year: 2004

Treg depletion reduces bleomycin-induced pulmonary fibrosis by inducing Th17 and other CD4+T cell subset responses in lung
Source: International Congress 2016 – IPF: from pathogenesis to treatment II
Year: 2016

Bronchial epithelial cells from COPD patients overproduce an upstream Th2 regulator cytokine in response to viral stimuli
Source: Annual Congress 2009 - Pathology and immunology of COPD
Year: 2009

T-helper 1 cells induce alveolitis but do not lead to pulmonary fibrosis in mice
Source: Eur Respir J 2003; 21: 11-18
Year: 2003



Oral presentation: Macrophages are required to maintain type-2 dependent inflammation, immunity and fibrosis
Source: Lung Science Conference 2014 - Lung Inflammation and Immunity
Year: 2014

Different Th1, Th2, Th17 and Treg associated chemokine local pattern expression in lung in a murine model of allergic inflammation
Source: Annual Congress 2011 - T-cell subsets
Year: 2011


Antifibrotics modulate B lymphocyte activation resulting in a decrease of the profibrotic milieu in patients with pulmonary fibrosis
Source: International Congress 2019 – Translational aspects of idiopathic interstitial pneumonia
Year: 2019


Activated lymphoid follicles, sign of an immune response, are present in early idiopathic pulmonary fibrosis (IPF) and increase with disease progression.
Source: Virtual Congress 2021 – Biomarkers and e-health in idiopathic interstitial pneumonia
Year: 2021


Lung lymphoid neogenesis in cystic fibrosis: a model of adaptive responses to bacteria?
Source: Eur Respir J , 49 (4)  1700380; DOI: 10.1183/13993003.00380-2017
Year: 2017


Inflammatory responses to individual organisms in the lungs of children with cystic fibrosis
Source: Annual Congress 2010 - Cystic fibrosis: lung disease and much more
Year: 2010

IL-17R-deficient mice generate a Th2 response and altered leukocyte trafficking in a model of pulmonary inflammation
Source: Eur Respir J 2003; 22: Suppl. 45, 194s
Year: 2003