The muscarinic receptors promote IL-8 release in airway epithelial cells via the pERK42/44 and NF-kB pathways

M. Profita, L. Siena, A. Bonanno, A. M. Montalbano, S. Castellana, L. Pipitone, M. Pieper, G. Bonsignore, M. Gjomarkaj (Palermo, Italy; Biberach, Germany)

Source: Annual Congress 2006 - Airway cell biology I
Session: Airway cell biology I
Session type: Electronic Poster Session
Number: 4278
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Profita, L. Siena, A. Bonanno, A. M. Montalbano, S. Castellana, L. Pipitone, M. Pieper, G. Bonsignore, M. Gjomarkaj (Palermo, Italy; Biberach, Germany). The muscarinic receptors promote IL-8 release in airway epithelial cells via the pERK42/44 and NF-kB pathways. Eur Respir J 2006; 28: Suppl. 50, 4278

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The purinergic receptor P2Y2 mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation
Source: Annual Congress 2010 - Asthma: basic science and clinical studies
Year: 2010

Activation of PAR-2 enhances ICAM-1 expression and IL-8 release in airway epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 571s
Year: 2002

CysLT1 receptor activation-induced adhesion of human eosinophils to bronchial epithelial cells: signal transduction and pharmacological modulation
Source: Eur Respir J 2005; 26: Suppl. 49, 368s
Year: 2005

Role of nicotinic receptors in the regulation of cytokines production by human lung macrophages
Source: Annual Congress 2012 - Mechanistic studies in airway cell biology
Year: 2012

The expression of muscarinic receptors is involved in the p42/44ERK and NF-kB activation of human lung fibroblasts from COPD subjects
Source: Eur Respir J 2006; 28: Suppl. 50, 102s
Year: 2006

Muscarinic receptors mediate up-regulation of endothelin-1 expression in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Toll-like receptor stimulation induces airway hyperresponsiveness to bradykinin, an effect mediated by JNK and NF-κB signaling pathways
Source: Eur Respir J 2005; 26: Suppl. 49, 732s
Year: 2005

Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils
Source: Eur Respir J 2003; 22: Suppl. 45, 548s
Year: 2003

Protease activated receptor 2 (PAR2) antagonism reduces pro-inflammatory cytokine production in bronchial epithelial cells
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


Effects of JAK-STAT inhibitors on glucocorticosteroid resistant release of CXCR3 chemokines from human bronchial epithelial cells
Source: Annual Congress 2011 - Epithelial cell biology
Year: 2011


Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells
Source: Eur Respir J 2009; 34: 1436-1443
Year: 2009



RANTES expression induced by Toll-like receptor 3 and 4 ligands on rat airway smooth muscle cells
Source: Annual Congress 2009 - Infections, immunity and inflammation
Year: 2009


Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases
Year: 2010

Serotonin (5-hydroxytryptamine) modulates cytokine and chemokine production in lipopolysaccharide-primed human monocytes via stimulation of different 5-HT receptor subtypes
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Effects of budesonide on p38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Eosinophil adhesion to cholinergic nerve cells induces NFκB activation via the interleukin-1 receptor associated kinase (IRAK) pathway and upregulates ICAM-1 expression
Source: Eur Respir J 2003; 22: Suppl. 45, 10s
Year: 2003

Glucocorticoids enhance CCL20 release in bronchial epithelial cells in a metalloprotease-dependent manner
Source: Annual Congress 2011 - Epithelial cell biology
Year: 2011


The up-regulation of cysteinyl-leukotriene receptors on T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 395s
Year: 2003

Interleukin-8 stimulates human airway epithelial cell proliferation through EGFR transactivation
Source: Eur Respir J 2003; 22: Suppl. 45, 561s
Year: 2003

Effect of muscarinic receptors inhibition on cytokine release and inflammatory cells infiltration in the airway of cat as an animal model for COPD
Source: Annual Congress 2012 - Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD
Year: 2012