Collagen itself perpetuates fibrotic remodeling via its immune-stimulating role upon alveolar macrophages and CCL18 production

A. Prasse, D. V. Pechkovsky, J. Müller-Quernheim, M. Stahl, G. Zissel (Freiburg, Germany)

Source: Annual Congress 2006 - Matrix remodelling at the interface of lung fibrosis and emphysema
Session: Matrix remodelling at the interface of lung fibrosis and emphysema
Session type: Oral Presentation
Number: 3556
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Prasse, D. V. Pechkovsky, J. Müller-Quernheim, M. Stahl, G. Zissel (Freiburg, Germany). Collagen itself perpetuates fibrotic remodeling via its immune-stimulating role upon alveolar macrophages and CCL18 production. Eur Respir J 2006; 28: Suppl. 50, 3556

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Collagen VI-producing macrophages mediate lung fibrosis
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Alveolar macrophage oxidative and pro-inflammatory cytokine activity in lung sarcoidosis
Source: Eur Respir J 2005; 26: Suppl. 49, 332s
Year: 2005

Increased SDF-1alpha production from alveolar macrophages in sarcoidosis in vitro
Source: Annual Congress 2008 - Sarcoidosis: pathophysiology and severity
Year: 2008

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages
Source: Eur Respir J, 55 (1) 1900646; 10.1183/13993003.00646-2019
Year: 2020



FIZZ1: a new pathway in silica-induced inflammatory mediators and pulmonary fibrosis
Source: International Congress 2018 – Occupational and environmental lung diseases: mechanisms, biomarkers and causation
Year: 2018

Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

Pulmonary interstitium remodeling by collagen V is associated with profibrotic cytocines in experimental systemic sclerosis
Source: Annual Congress 2007 - Miscellaneous interstitial lung diseases related to systemic and other diseases
Year: 2007


Thalidomide reduces IL-18, IL-8 and TNF-α release from alveolar macrophages in interstitial lung disease
Source: Eur Respir J 2006 Oct 01;28(4):824-831
Year: 2006



Eosinophils contribute to extracellular matrix remodeling by enhancing pulmonary fibroblasts proliferation, differentiation and extracellular matrix proteins production in asthma
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

Protein S inhibits the secretion of inflammatory cytokines from alveolar epithelial cells
Source: Annual Congress 2008 - Structural remodelling in COPD
Year: 2008

Alpha1-Antitrypsin reduces endoplasmic reticulum stress, inflammatory cytokines and improves wound repair in alveolar epithelial cells of fibrotic lung in vitro
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

Nintedanib inhibits pro-fibrotic mediators from T cells with relevance to connective tissue disease-associated interstitial lung disease
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

Smooth-muscle-derived WNT-5A drives allergen-induced remodelling and Th2 type inflammation
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018

Collagen V nasal tolerance reverts pulmonary immune cells proliferation and interstitium remodeling in experimental scleroderma
Source: Annual Congress 2007 - Miscellaneous interstitial lung diseases related to systemic and other diseases
Year: 2007


Increased production of caspase-1 by alveolar macrophages in patients with pulmonary sarcoidosis
Source: Eur Respir J 2002; 20: Suppl. 38, 585s
Year: 2002

Matrix metalloproteinase (MMP)-2 production by fibroblasts and mast cells: the role in pulmonary fibrosis
Source: Eur Respir J 2004; 24: Suppl. 48, 455s
Year: 2004

Increased in vitro production of IP-10/CXCL10 and MIG/CXCL9 by alveolar macrophages in sarcoidosis and EAA but not in IPF
Source: Annual Congress 2008 - Role of bronchoalveolar lavage in studying the pathophysiology of interstitial lung disease
Year: 2008

Cytokine production of alveolar macrophages is decreased by OR2AT4
Source: Virtual Congress 2021 – New insights into the airway immunology of lung disease
Year: 2021


The role of chemokines and cytokines in lung fibrosis
Source: Eur Respir Rev 2008; 17: 151-156
Year: 2008



Glucocorticoids induce a shift in chemokine profile in LPS-stimulated human alveolar macrophages
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018