Dose-related efficacy of vilanterol trifenatate (VI), a long-acting beta2 agonist (LABA) with inherent 24-hour activity, in patients with persistent asthma

J. Lötvall, E. D. Bateman, E. R. Bleecker, W. Busse, A. Woodcock, R. Follows, J. Lim, S. Stone, L. Jacques, B. Haumann (Gothenberg, Sweden; Cape Town, South Africa; Winston-Salem, Madison, United States Of America; Manchester, London, United Kingdom)

Source: Annual Congress 2010 - Bronchodilators in airways disease
Session: Bronchodilators in airways disease
Session type: Oral Presentation
Number: 5554
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Lötvall, E. D. Bateman, E. R. Bleecker, W. Busse, A. Woodcock, R. Follows, J. Lim, S. Stone, L. Jacques, B. Haumann (Gothenberg, Sweden; Cape Town, South Africa; Winston-Salem, Madison, United States Of America; Manchester, London, United Kingdom). Dose-related efficacy of vilanterol trifenatate (VI), a long-acting beta2 agonist (LABA) with inherent 24-hour activity, in patients with persistent asthma. Eur Respir J 2010; 36: Suppl. 54, 5554

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Safety and tolerability of the novel inhaled corticosteroid (ICS) fluticasone furoate (FF) in combination with the long-acting beta2 agonist (LABA) vilanterol (VI) administered once daily (OD) in patients with asthma
Source: Annual Congress 2012 - Asthma treatment: efficacy and safety
Year: 2012

Safety of fluticasone furoate (FF), an inhaled corticosteroid in combination with vilanterol (VI), a long-acting beta agonist in management of COPD exacerbations
Source: Annual Congress 2012 - COPD treatments: efficacy and safety
Year: 2012

Dose-related efficacy of vilanterol trifenatate (VI) in COPD
Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Year: 2010

24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids},
Source: Eur Respir J 2012; 40: 570-579
Year: 2012



Vilanterol, a novel inhaled long-acting β2 adrenoceptor agonist (LABA), demonstrates extensive first pass clearance to metabolites with negligible pharmacological activity in man
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Pharmacokinetic (PK) analysis of fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) following triple therapy at two UMEC doses in healthy subjects
Source: International Congress 2014 – Rationale behind respiratory drug development
Year: 2014


Inhaled corticosteroid (ICS) and long-acting beta2-agonist (LABA) combination vs. high doses of ICS: efficacy and safety in patients (pts) with uncontrolled occupational asthma
Source: International Congress 2017 – Techniques to treat asthma
Year: 2017

Efficacy and safety of inhaled corticosteroid‘s (ICS) and long-acting beta-agonist‘s (LABA) combination in asthma (A) patients
Source: Eur Respir J 2004; 24: Suppl. 48, 125s
Year: 2004

Pharmacokinetic (PK) analysis of fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) following triple therapy in healthy subjects
Source: International Congress 2014 – Asthma and COPD management
Year: 2014


Fluticasone furoate (FF), a once-daily inhaled corticosteroid (ICS), demonstrates dose-response efficacy in patients symptomatic on non-steroidal asthma therapy
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Salmeterol/fluticasone combination (SFC) is associated with improved asthma control compared with concurrent long-acting β2 agonists (LABA) and inhaled corticosteroids (ICS) or ICS alone
Source: Eur Respir J 2003; 22: Suppl. 45, 235s
Year: 2003

Efficacy of fluticasone furoate (FF) as a monotherapy and in combination with vilanterol (VI) over 12 weeks in patients with persistent asthma
Source: Annual Congress 2012 - Asthma treatment: efficacy and safety
Year: 2012

The absolute bioavailability of fluticasone furoate (FF) and vilanterol (VI) trifenatate following inhaled administration in combination in healthy subjects
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

Fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), demonstrates once-daily (OD) efficacy in asthma when dosed in the evening
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Safety, pharmacokinetics (PK) and pharmacodynamics (PD) of single doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist (LAMA), in patients with COPD
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Fluticasone furoate (FF), an inhaled corticosteroid (ICS), demonstrates efficacy in asthma patients symptomatic on moderate doses of ICS therapy
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Tiotropium bromide (TIO) reduces hospitalizations in patients with COPD who had been refractory to treatment with combined inhaled corticosteroid/long acting beta agonist (ICS/LABA)
Source: Eur Respir J 2005; 26: Suppl. 49, 717s
Year: 2005

The efficacy of inhaled fluticasone furoate (FF) and vilanterol (VI) administered in combination in asthma is comparable when administered in the morning or evening
Source: Annual Congress 2012 - Asthma treatment: efficacy and safety
Year: 2012

Efficacy of the novel inhaled corticosteroid, fluticasone furoate (FF)/long-acting beta2-agonist, vilanterol (VI) combination in reducing COPD exacerbations
Source: Annual Congress 2012 - Trials in COPD: novel treatments and insights
Year: 2012

Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011