MMP expression and abnormal lung permeability are important determinants of outcome in IPF

McKeown S., Richter A. G., O'Kane C., McAuley D. F., Thickett D. R.

Source: Eur Respir J 2009; 33: 77-84
Journal Issue: January
Disease area: Interstitial lung diseases, Pulmonary vascular diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
McKeown S., Richter A. G., O'Kane C., McAuley D. F., Thickett D. R.. MMP expression and abnormal lung permeability are important determinants of outcome in IPF. Eur Respir J 2009; 33: 77-84

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL-11 promotes pulmonary vascular remodeling and lung fibrosis through the activation of endothelial to mesenchymal transition.
Source: Virtual Congress 2020 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2020

VEGF reduces pulmonary hypertension and vascular remodeling in pulmonary fibrosis through reduced endothelial apoptosis
Source: Annual Congress 2009 - Pulmonary circulation I
Year: 2009

Role of endothelin in lung fibrosis
Source: Eur Respir Rev 2008; 17: 145-150
Year: 2008



Vascular endothelial growth factor (VEGF) and airway inflammation in COPD. Correlation with pulmonary function
Source: Eur Respir J 2006; 28: Suppl. 50, 653s
Year: 2006

Increased binding activity of hypoxia inducible factor (HIF)-1α to vascular endothelial growth factor (VEGF) promoter region mediates enhanced vascular permeability in the lung of cystic fibrosis (CF) patients
Source: Eur Respir J 2003; 22: Suppl. 45, 173s
Year: 2003

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into myofibroblasts
Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung
Year: 2009

Bioavailability of vascular endothelial growth factor (VEGF)? A role in pulmonary fibrosis?
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012

Arterial remodelling in patients with idiopathic pulmonary fibrosis (IPF) and the possible role of endothelial to mesenchymal transition (EndMT)
Source: Virtual Congress 2021 – Mechanistic pathways in chronic and new lung diseases
Year: 2021



Role of matrix metalloproteinases in progression of idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Pathogenesis of diffuse parenchymal lung disease
Year: 2010

Treprostinil effectively inhibits PDGF and TGF-ß1 induced extracellular matrix composition by IPF fibroblasts
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015

Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 444s
Year: 2006

The role of pathological angiogenesis in the pathogenesis of the chronic inflammatory lung diseases
Source: Annual Congress 2005 - Update on the role of angiogenesis in the pathogenesis and treatment of lung diseases
Year: 2005

Imbalance between vascular endothelial growth factor and endostatin in emphysema
Source: Eur Respir J 2003 Oct 01;22(4):609-612
Year: 2003



Role of IL-11 in vascular function of pulmonary fibrosis patients
Source: International Congress 2019 – Pulmonary hypertension with lung diseases and experimental pulmonary hypertension
Year: 2019

Matrix metalloproteinase (MMP)-2 production by fibroblasts and mast cells: the role in pulmonary fibrosis
Source: Eur Respir J 2004; 24: Suppl. 48, 455s
Year: 2004

Increased fibrinolytic mediators in IPF as potential contributors to pulmonary fibrosis and vascular remodeling
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Tranilast inhibits pulmonary fibrosis by suppressing TGFbeta-mediated extracellular matrix protein production
Source: Annual Congress 2013 –Diffuse pulmonary fibrosis
Year: 2013

Morphometric study of hypoxia inducible factor-1α-vascular endothelial growth factor (HIF-1α-VEGF) axis in patients with idiopathic pulmonary fibrosis with the use of tissue microarrays
Source: Eur Respir J 2006; 28: Suppl. 50, 338s
Year: 2006

A role for vascular endothelial growth factor (VEGF) in fibrosis?
Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung
Year: 2009

The prognostic role of matrix metalloproteinase-7 in scleroderma-associated interstitial lung disease
Source: Eur Respir J, 58 (6) 2101560; 10.1183/13993003.01560-2021
Year: 2021