Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues
E. Selg, C. Buccellati, M. Andersson, G. Rovati, M. Ezinga, A. Sala, A. K. Larsson, E. Ambrosio, L. Låstbom, V. Capra, B. Dahlén, A. Ryrfeldt, G. Folco, S. E. Dahlén (Stockholm, Sweden; Milano, Italy)
Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology
Session: Recent advances in airway smooth muscle biology
Session type: Oral Presentation
Number: 4233
Disease area: Airway diseases
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
E. Selg, C. Buccellati, M. Andersson, G. Rovati, M. Ezinga, A. Sala, A. K. Larsson, E. Ambrosio, L. Låstbom, V. Capra, B. Dahlén, A. Ryrfeldt, G. Folco, S. E. Dahlén (Stockholm, Sweden; Milano, Italy). Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues. Eur Respir J 2007; 30: Suppl. 51, 4233
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in the airway remodeling induced by chronic airway inflammation in guinea pigs Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II Year: 2008
Alpha-1L, but not alpha-1H, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo Source: Eur Respir J 2001; 18: Suppl. 33, 104s Year: 2001
PGD2 induces constriction of the peripheral guinea pig lung via the TP receptor Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD Year: 2008
Effect of thromboxane A2 (TXA2 ) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs Source: Eur Respir J 2001; 18: Suppl. 33, 264s Year: 2001
Prostacyclin IP receptor activation blocks hyperosmolar-induced bronchoconstriction in isolated human small airways Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action Year: 2016
A novel TRPA1 antagonist inhibits ovalbumin-induced bronchoconstriction in guinea pig models Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets Year: 2019
Bronchoconstriction induced by prostaglandin D2 (PGD2 ) in guinea pig lung is enhanced by selective COX-2 inhibition Source: Eur Respir J 2006; 28: Suppl. 50, 759s Year: 2006
The effects of PGD2 and DK-PGD2 on features of airway remodeling in human airway epithelial cells and guinea pig lung slices Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma Year: 2020
The cannabinoid receptor agonist, WIN 55,212-2, inhibits antigen-induced plasma extravasation in guinea pig airways Source: Annual Congress 2010 - Models of airways disease Year: 2010
Endothelin-1-induced airway and parenchymal mechanical responses in guinea-pigs: the roles of ETA and ETB receptors Source: Eur Respir J 2001; 17: 975-981 Year: 2001
Late asthmatic response is modulated by TRPA1 antagonists in ovalbumin-induced bronchoconstriction in anaesthetized guinea pigs Source: Annual Congress 2012 - New drug targets and pre-clinical models for respiratory diseases Year: 2012
Effects of a newly developed dual CysLT1 and CysLT2 receptor antagonist, ONO-RS-531, on antigen- and leukotriene D4 -induced contractions of isolated human bronchi Source: Eur Respir J 2005; 26: Suppl. 49, 214s Year: 2005
Involvement of NK1, 2 and 3 receptors on antigen-induced airway hyperresponsiveness and inflammation induced in guinea-pigs Source: Eur Respir J 2001; 18: Suppl. 33, 246s Year: 2001
Effects of neurokinins on nNOS expression in bronchial epithelial and inflammatory cells in airways of guinea pigs Source: Eur Respir J 2005; 26: Suppl. 49, 340s Year: 2005
Fevipiprant reduces airway smooth muscle mass in asthmatics via PGD2 receptor antagonism Source: International Congress 2017 – Novel mechanisms and treatments for asthma Year: 2017
Interactions between the β2 adrenoceptor and the COX enzyme system during relaxation in guinea pig trachea Source: Annual Congress 2007 - Recent advances in our understanding of the mechanisms of asthma treatment Year: 2007
The mediators of allergen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung (IPL) are closely similar to those in asthmatics Source: Eur Respir J 2003; 22: Suppl. 45, 104s Year: 2003
Inhaled roflumilast and tadalafil supress airway reactivity and inflammation in ovalbumin-sensitized guinea pigs Source: International Congress 2016 – Preclinical pharmacology: drug targets and mechanisms of action Year: 2016
CS-003, a novel triple neurokinin receptor antagonist, inhibits symptoms of respiratory diseases models in guinea pigs Source: Eur Respir J 2006; 28: Suppl. 50, 664s Year: 2006
Effect of muscarinic receptors inhibition on cytokine release and inflammatory cells infiltration in the airway of cat as an animal model for COPD Source: Annual Congress 2012 - Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD Year: 2012