Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways

M. Ichinose, H. Sugiura, S. Yamagata, A. Koarai, M. Tomaki, H. Ogawa, Y. Komaki, P.J. Barnes, K. Shirato, T. Hattori.

Source: Eur Respir J 2004; 23: 496
Journal Issue: March
Disease area: Airway diseases

PDF journal article, handout or slidesFull text journal article

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Ichinose, H. Sugiura, S. Yamagata, A. Koarai, M. Tomaki, H. Ogawa, Y. Komaki, P.J. Barnes, K. Shirato, T. Hattori.. Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways. Eur Respir J 2004; 23: 496

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways
Source: Eur Respir J 2003; 22: 457-461
Year: 2003



In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by a1-antitrypsin
Source: ERJ Open Res, 7 (4) 00234-2021; 10.1183/23120541.00234-2021
Year: 2021



Apocynin reduces reactive oxygen species generation in airways of asthmatics
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Inhibition of reactive nitrogen species production in COPD airways: comparison between steroid and theophylline
Source: Eur Respir J 2005; 26: Suppl. 49, 293s
Year: 2005

Superoxide production by the Nox4 based NAD(P)H oxidase is increased in bronchial biopsies from asthmatic patients. Relationship to lung function
Source: Eur Respir J 2004; 24: Suppl. 48, 683s
Year: 2004

Role of complex I and III in the production of reactive oxygen species by mitochondria of peripheral muscle in COPD subjects
Source: Annual Congress 2009 - Gas exchange and exercise in respiratory diseases
Year: 2009

Altered mitochondrial reactive oxygen species (ROS) production in airway smooth muscle cells of severe asthma.
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

Hypoxia and reoxygenation modulate lung epithelial cell glutathione content, oxygen consumption and reactive oxygen species (ROS) production
Source: Eur Respir J 2001; 18: Suppl. 33, 182s
Year: 2001

Xanthine oxidase inhibitors reduce rhinovirus induced IL-8 and GRO-α production in bronchial epithelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 721s
Year: 2007

Influence of AECOPD to ROS production in neutrophils
Source: Annual Congress 2011 - COPD: human studies
Year: 2011

Analysis of reactive oxygen species in sputum neutrophils during acute exacerbation of COPD
Source: Annual Congress 2012 - Inflammatory mechanisms in COPD
Year: 2012

Altered reactive oxygen species generation in neutrophils of children with pollinosis
Source: Eur Respir J 2005; 26: Suppl. 49, 589s
Year: 2005

Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing
Source: Eur Respir J 2010; 36: 1056-1066
Year: 2010



Production of superoxide anions by the NADPH oxidase in mammalian skeletal muscles
Source: Eur Respir J 2001; 18: Suppl. 33, 421s
Year: 2001

Increased production of reactive oxygen species of systemic PMN from COPD patients in comparison to healthy controls
Source: Annual Congress 2010 - Novel mechanisms in COPD
Year: 2010


Nitric oxide generation during human neutrophil respiratory burst is reduced by thiolic metabolite-1 of erdosteine (Met 1)
Source: Eur Respir J 2003; 22: Suppl. 45, 435s
Year: 2003

Hydrogen gas alters the production of reactive oxygen species in alveolar epithelial cells in vitro
Source: Annual Congress 2012 - Lung injury and repair: reactive oxygen species and beyond
Year: 2012

Effects of inducible nitric oxide synthase and xanthine oxidase inhibitors on SEB-induced interstitial pneumonia in mice
Source: Eur Respir J 2002; 19: 447-457
Year: 2002



Reactive oxygen and nitrogen species (ROS & RNS) are associated with respiratory muscle dysfunction in severe COPD patients
Source: Eur Respir J 2004; 24: Suppl. 48, 120s
Year: 2004

Reversible inhibition of mitochondrial complex IV activity in PBMC following acute smoking
Source: Eur Respir J 2004; 23: 214-218
Year: 2004