The transforming growth factor-β/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension

Zakrzewicz A., Kouri F. M., Nejman B., Kwapiszewska G., Hecker M., Sandu R., Dony E., Seeger W., Schermuly R. T., Eickelberg O., Morty R. E.

Source: Eur Respir J 2007; 29: 1094-1104
Journal Issue: June
Disease area: Pulmonary vascular diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Zakrzewicz A., Kouri F. M., Nejman B., Kwapiszewska G., Hecker M., Sandu R., Dony E., Seeger W., Schermuly R. T., Eickelberg O., Morty R. E.. The transforming growth factor-β/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension. Eur Respir J 2007; 29: 1094-1104

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PDGF promotes pulmonary artery smooth muscle cell proliferation and migration in pulmonary arterial hypertension
Source: Annual Congress 2006 - Signalisation in the pulmonary vasculature: new pathways and wrong signals
Year: 2006


Apoptosis and cell proliferation in chronic hypoxic pulmonary hypertension
Source: Lung Science Conference 2007 - Translational research in pulmonary disease: Hypoxia-driven mechanisms
Year: 2007


The effect of ASK1 inhibition on hypoxia-induced pulmonary artery fibroblast activation and associated paracrine effects on vascular smooth muscle cells
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

The effects of hypoxia on the cells of the pulmonary vasculature
Source: Eur Respir J 2007; 30: 364-372
Year: 2007



Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells - role of hypoxia-inducible transcription factors
Source: Eur Respir J 2001; 18: Suppl. 33, 159s
Year: 2001

Involvement of FHL1 in vascular remodelling
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006


Pathobiology of pulmonary arterial hypertension
Source: Eur Respir J 2002; 20: 1559-1572
Year: 2002



Transforming growth factor-β type II receptor in pulmonary arteries of patients with very severe COPD
Source: Eur Respir J 2006; 28: 556-562
Year: 2006



VEGF reduces pulmonary hypertension and vascular remodeling in pulmonary fibrosis through reduced endothelial apoptosis
Source: Annual Congress 2009 - Pulmonary circulation I
Year: 2009

Inhibition of the Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
Source: Annual Congress 2006 - Pulmonary circulation: inflammation and remodelling
Year: 2006


Shroom expression is attenuated in pulmonary arterial hypertension
Source: Eur Respir J 2008; 32: 871-880
Year: 2008



Sildenafil modulates PDGF and Angiotensin II induced migration and proliferation in human pulmonary artery smooth muscle cells (PA-SMC)
Source: Eur Respir J 2002; 20: Suppl. 38, 227s
Year: 2002

Increased p130Cas activity induces smooth muscle cell proliferation and migration in idiopathic pulmonary arterial hypertension
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011


Hypoxia-induced increase in NO production and eNOS expression by murine pulmonary microvascular endothelial cells
Source: Annual Congress 2006 - Pulmonary circulation: inflammation and remodelling
Year: 2006


Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension
Source: Eur Respir J 2008; 32: 1504-1512
Year: 2008



Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH},
Source: Eur Respir J 2012; 40: 618-629
Year: 2012



Pulmonary artery endothelial cell exposure to hepcidin affects BMP-signalling; relevance to vascular remodelling in PAH
Source: Virtual Congress 2020 – Experimental approaches to pulmonary hypertension
Year: 2020


Pulmonary hypertension: the science behind the disease spectrum
Source: Eur Respir Rev 2012; 21: 19-26
Year: 2012



Nerve growth factor expression and function in pulmonary arterial hypertension
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010

Imbalance between vascular endothelial growth factor and endostatin in emphysema
Source: Eur Respir J 2003 Oct 01;22(4):609-612
Year: 2003