IGF1R facilitates implantation and progression of lung metastasis acting in the tumor microenvironment

E. Alfaro Arnedo (Logroño, Spain), I. López (Logroño, Spain), S. Piñeiro-Hermida (Madrid, Spain), M. Canalejo (Logroño, Spain), C. Ruíz-Martinez (Logroño, Spain), J. Pichel (Logroño, Spain)

Source: Virtual Congress 2021 – Biology of lung cancer: preclinical and translational research
Session: Biology of lung cancer: preclinical and translational research
Session type: E-poster
Number: 1119

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. Alfaro Arnedo (Logroño, Spain), I. López (Logroño, Spain), S. Piñeiro-Hermida (Madrid, Spain), M. Canalejo (Logroño, Spain), C. Ruíz-Martinez (Logroño, Spain), J. Pichel (Logroño, Spain). IGF1R facilitates implantation and progression of lung metastasis acting in the tumor microenvironment. 1119

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PP133 – IGF1R acts in the tumor microenvironment as a cancer-promoting factor facilitating the implantation and progression of lung metastasis
Source: ERS Lung Science Conference 2021
Year: 2021

Tumor-related angiogenesis: role in tumour growth and metastasis formation
Source: Annual Congress 2005 - Update on the role of angiogenesis in the pathogenesis and treatment of lung diseases
Year: 2005

Effects of tumor stroma and inflammation on survival of stage I-IIp lung cancer
Source: International Congress 2017 – Clinical research in lung cancer: new valuable results on lung cancer detection, prognostic biomarkers, and tyrosine kinase inhibitors
Year: 2017

Interleukin-17 enhances the net angiogenic potential and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
Source: Eur Respir J 2004; 24: Suppl. 48, 79s
Year: 2004

Splenectomy inhibits tumor development and metastases in murine lung cancer models
Source: Annual Congress 2012 - Screening, diagnosis, staging and treatment strategies for lung cancer
Year: 2012


Circulating fibrocytes depletion results in reduced lung tumor growth and metastasis by modulating macrophage phenotype, angiogenesis and endothelin system
Source: ERS Lung Science Conference 2017
Year: 2017

MicroRNA-101 inhibits lung cancer growth and invasion through regulation of EZH2
Source: Annual Congress 2010 - Pathology of lung cancer
Year: 2010

EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells
Source: Virtual Congress 2020 – Molecular alterations and immunology in lung cancer
Year: 2020

High CO2 tumor microenvironment confers chemoresistance in lung cancer cells.
Source: International Congress 2017 – Lung cancer: latest basic research on molecular alterations, tumour-immune system-microenvironment interplay and the metabolome
Year: 2017



Inhibition of tumor growth and metastatic lung tumors in mice by adenovirus-mediated interferon-β gene therapy
Source: Eur Respir J 2003; 22: Suppl. 45, 199s
Year: 2003

Apoptosis, tumor cell proliferation and angiogenesis as prognostic factor in lung cancer
Source: Eur Respir J 2004; 24: Suppl. 48, 78s
Year: 2004

Adenoviral transduction of MRP-1/CD9 and KAI-1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model
Source: Eur Respir J 2006; 28: Suppl. 50, 389s
Year: 2006

Vascular endothelial growth factor (VEGF) expression in non small cell lung cancer and its association with histopathologic type, stage, lymphnode involvement, recurrence and distant metastasis
Source: Eur Respir J 2003; 22: Suppl. 45, 393s
Year: 2003

Overexpression of LincR-PICALM promotes lung cancer proliferation and metastasis by miR-199a-3p suppression and cis- regulation
Source: International Congress 2019 – Novel molecular pathways in lung cancer and COPD
Year: 2019

Carbohydrate-induced conformational MUC1 tumor-epitope correlates with improved post-surgical survival of non-small cell lung cancer patients with local or distant metastasis
Source: Eur Respir J 2006; 28: Suppl. 50, 150s
Year: 2006

Adenylate cyclase-associated protein 1 is associated with metastasis of non-small cell lung cancer especially in brain metastasis patients and promotes the lung cancer cell proliferation and migration in vitro as well as its growth and metastasis in vivo by the signaling pathways of limk1-cofilin
Source: International Congress 2015 – New frontiers in biomedical research on thoracic tumours
Year: 2015


Adenovirus-mediated interferon-beta gene therapy inhibits tumor growth and inhibits metastatic lung tumors in mice
Source: Eur Respir J 2002; 20: Suppl. 38, 186s
Year: 2002

The activation of MET-driven invasive growth in IPF and metastasis is modulated by different mechanisms of cell/matrix interaction
Source: ERS Lung Science Conference 2018
Year: 2018


Mast cells act as partners in tumour cells metastasis to promote angiogenesis via exosomes
Source: International Congress 2019 – Biology of lung cancer
Year: 2019