The commensal bacterium Rothia mucilaginosa has anti-inflammatory properties in vitro and in vivo, and negatively correlates with sputum pro-inflammatory markers in chronic airway disease.

C. Rigauts (Ghent, Belgium), J. Aizawa (Anwerp, Belgium), S. Taylor (Adelaide, Australia), G. Rogers (Adelaide, Australia), M. Govaerts (Anwerp, Belgium), P. Cos (Anwerp, Belgium), L. Ostyn (Ghent, Belgium), S. Sims (Adelaide, Australia), E. Vandeplassche (Ghent, Belgium), M. Sze (Ghent, Belgium), Y. Dondelinger (Ghent, Belgium), L. Vereecke (Ghent, Belgium), H. Van Acker (Ghent, Belgium), J. Simpson (New South Wales, Australia), L. Burr (South Brisbane, Australia), A. Willems (GhentBrisbane, Belgium), M. Tunney (Belfast, Ireland), C. Cigana (Milan, Italy), A. Bragonzi (Milan, Italy), T. Coenye (Ghent, Belgium), A. Crabbé (Ghent, Belgium)

Source: Virtual Congress 2021 – Emerging new mechanisms of chronic lung disease
Session: Emerging new mechanisms of chronic lung disease
Session type: E-poster
Number: 873

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Rigauts (Ghent, Belgium), J. Aizawa (Anwerp, Belgium), S. Taylor (Adelaide, Australia), G. Rogers (Adelaide, Australia), M. Govaerts (Anwerp, Belgium), P. Cos (Anwerp, Belgium), L. Ostyn (Ghent, Belgium), S. Sims (Adelaide, Australia), E. Vandeplassche (Ghent, Belgium), M. Sze (Ghent, Belgium), Y. Dondelinger (Ghent, Belgium), L. Vereecke (Ghent, Belgium), H. Van Acker (Ghent, Belgium), J. Simpson (New South Wales, Australia), L. Burr (South Brisbane, Australia), A. Willems (GhentBrisbane, Belgium), M. Tunney (Belfast, Ireland), C. Cigana (Milan, Italy), A. Bragonzi (Milan, Italy), T. Coenye (Ghent, Belgium), A. Crabbé (Ghent, Belgium). The commensal bacterium Rothia mucilaginosa has anti-inflammatory properties in vitro and in vivo, and negatively correlates with sputum pro-inflammatory markers in chronic airway disease.. 873

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Streptococcus pneumoniae augments inflammatory process in asthma model without changing Th2 profile
Source: Virtual Congress 2020 – Monitoring of inflammation in remodelling
Year: 2020


Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells
Source: Eur Respir J 2011; 37: 53-64
Year: 2011



Reduced phagocytosis of bacterial pathogens by macrophages from COPD patients
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010

A subset of COPD patients defined by lung epithelial IL-6 trans-signalling is associated with neutrophilic inflammation and colonization by Haemophilus influenzae
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019


Differential inflammatory effects of colonising airway bacteria in COPD
Source: Eur Respir J 2004; 24: Suppl. 48, 686s
Year: 2004

Reduced phagocytosis of pathogenic bacteria by neutrophils from COPD patients
Source: Annual Congress 2012 - Update on neutrophil and macrophage function in COPD
Year: 2012

The role of pathogenic bacterial colonisation in neutrophilic airways inflammation in severe asthma
Source: Annual Congress 2009 - Novel mechanisms in the pathogenesis of asthma
Year: 2009

Chlamydia pneumoniae enhances infection with Haemophilus influenzae, up-regulates TLR2-expression in human lung tissue and leads to enhanced chemokine production after coinfection – a possible mechanism for COPD exacerbations
Source: Annual Congress 2008 - New diagnostic methods in viral and atypical infections
Year: 2008

The balance of pro- and anti - inflammatory cytokines in Chlamydia pneumoniae infected cells as a marker of inflammatory activity in the pulmonary compartment
Source: Eur Respir J 2001; 18: Suppl. 33, 154s
Year: 2001

The antimicrobial peptide CRAMP is a regulator of inflammation during pneumonia
Source: Annual Congress 2006 - Immunology of the airways
Year: 2006


The attenuation of cytokine response might be correlated with gut dysbiosis in nontuberculous mycobacteria lung disease
Source: International Congress 2019 – Tuberculosis: from basic science to patient care
Year: 2019

The species-specific inflammatory response of colonising bacteria in stable COPD
Source: Annual Congress 2013 –COPD: markers and inflammation
Year: 2013


Xylitol affects production of virulence factors and biofilm in pseudomonas aeruginosa; effects on respiratory epithelium inflammation. "In vitro" studies
Source: Annual Congress 2013 –Cystic fibrosis: basic and applied science
Year: 2013


Acinetobacter lwoffii and lactococcus lactis strains isolated from cowsheds of traditional farms suppress allergic airway inflammation in a mouse model of experimental asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 736s
Year: 2007

Spontaneous sputum production as a marker of bacterial colonisation in stable COPD
Source: Annual Congress 2005 - Acute and chronic infections in COPD
Year: 2005


In vivo evidence for aspergillus fumigatus and pseudomonas aeruginosa driven th-17 type inflammatory responses in the lungs of CF-patients
Source: Annual Congress 2009 - Cystic fibrosis: understanding a complex disease
Year: 2009


Azithromycin protects bronchial epithelial integrity after Pseudomonas aeruginosa infection independent of bactericidal activity
Source: Annual Congress 2008 - Best of lung epithelial cells 2008
Year: 2008



Macrolide effects on the prevention of COPD exacerbations
Source: Eur Respir J 2012; 40: 485-494
Year: 2012



Pseudomonas aeruginosa influences the inflammatory response of primary bronchial epithelial cells to rhinovirus infection
Source: Virtual Congress 2020 – Advances in cystic fibrosis: from microbiome to MRI
Year: 2020



ExoU-induced procoagulant activity in Pseudomonas aeruginosa-infected airway cells
Source: Eur Respir J 2008; 32: 1591-1598
Year: 2008