A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19

Dave Singh, Maxim Bogus, Valentyn Moskalenko, Robert Lord, Edmund J. Moran, Glenn D. Crater, David L. Bourdet, Nathan D. Pfeifer, Jacky Woo, Elad Kaufman, David A. Lombardi, Emily Y. Weng, Tuan Nguyen, Ashley Woodcock, Brett Haumann, Rajeev Saggar

Source: Eur Respir J, 58 (4) 2100673; 10.1183/13993003.00673-2021
Journal Issue: October

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Dave Singh, Maxim Bogus, Valentyn Moskalenko, Robert Lord, Edmund J. Moran, Glenn D. Crater, David L. Bourdet, Nathan D. Pfeifer, Jacky Woo, Elad Kaufman, David A. Lombardi, Emily Y. Weng, Tuan Nguyen, Ashley Woodcock, Brett Haumann, Rajeev Saggar. A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19. Eur Respir J, 58 (4) 2100673; 10.1183/13993003.00673-2021

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Phase 1 demonstrates LYT-100 (deupirfenidone) is dose-proportional and well-tolerated when given twice-daily over multiple ascending doses (MAD) and shows a minor food effect (FE)
Source: Virtual Congress 2021 – News in treatment and diagnosis of idiopathic interstitial pneumonia
Year: 2021


Efficacy and safety of four doses of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor (PDE4i), in patients with moderate-to-severe COPD
Source: International Congress 2019 – COPD clinical trials: new molecules and novel insights
Year: 2019



Dose-dependent inhibitory effect of Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, on allergen-induced early and late asthmatic reaction
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

Safety, tolerability and pharmacokinetics (PK) of AZD8154 (a selective PI3K?d inhibitor) after single ascending inhaled doses in healthy volunteers
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

A phase 1 multiple dose safety and pharmacokinetics study of AIR645, an inhaled IL-4rα 2-MOE GAPMER oligonucleotide
Source: Annual Congress 2009 - New drugs for airways disease
Year: 2009

No interaction of roflumilast, a new, orally active, selective PDE4 inhibitor, with inhaled salbutamol
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast, a selective phosphodiesterase 4 inhibitor, shows efficacy and safety in the long-term treatment of asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 203s
Year: 2003

Cilomilast, a potent, selective inhibitor of phosphodiesterase 4, improves small airway function in patients with chronic obstructive pulmonary disease: results of a 6-month trial
Source: Eur Respir J 2001; 18: Suppl. 33, 94s
Year: 2001

Chronic inhalation toxicity study of nebulized alpha1 proteinase inhibitor (alpha1-PI), TAL6005, in rodents
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


Ensifentrine, a novel dual phosphodiesterase (PDE) 3 and 4 inhibitor, provides effective bronchodilation when administered by dry powder inhaler in COPD
Source: International Congress 2019 – COPD clinical trials: new molecules and novel insights
Year: 2019




Fixed combination of glycopyrrolate and formoterol MDI (GFF-MDI) demonstrates superior inspiratory capacity (IC) compared to tiotropium DPI (Tio) following 7 days dosing, in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011

Roflumilast, a new, orally active, selective PDE4 inhibitor, does not interact with inhaled budesonide
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

No-effect doses for effects on growth velocity (GV) in children receiving corticosteroids (CS)
Source: Eur Respir J 2003; 22: Suppl. 45, 310s
Year: 2003

High oral absolute bioavailability of roflumilast, a new, orally active, once daily PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

Roflumilast, an oral, once-daily PDE4 inhibitor, improves lung function and reduces exacerbation rates in patients with COPD
Source: Eur Respir J 2004; 24: Suppl. 48, 21s
Year: 2004

An innovative phase II trial to establish proof of efficacy and optimal dose of a new inhaled epithelial sodium channel inhibitor BI 1265162 in adults and adolescents with cystic fibrosis: BALANCE-CFTM 1
Source: ERJ Open Res, 6 (4) 00395-2020; 10.1183/23120541.00395-2020
Year: 2020



Late Breaking Abstract - RPL554, a first-in-class dual PDE3/4 inhibitor, causes significant bronchodilation and symptom relief; a Phase 2b COPD study
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018



Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is safe and well tolerated in patients with chronic obstructive pulmonary disease
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

Roflumilast, a new orally active phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease
Source: Eur Respir J 2002; 20: Suppl. 38, 374s
Year: 2002