Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis

Sang-Hun Kim, Jung Yeon Lee, Chang Min Yoon, Hyeon Jun Shin, Sei Won Lee, Ivan Rosas, Erica Herzog, Charles S. Dela Cruz, Naftali Kaminski, Min-Jong Kang

Source: Eur Respir J, 57 (4) 2000652; 10.1183/13993003.00652-2020
Journal Issue: April
Disease area: Interstitial lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Sang-Hun Kim, Jung Yeon Lee, Chang Min Yoon, Hyeon Jun Shin, Sei Won Lee, Ivan Rosas, Erica Herzog, Charles S. Dela Cruz, Naftali Kaminski, Min-Jong Kang. Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis. Eur Respir J, 57 (4) 2000652; 10.1183/13993003.00652-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
MAV(S)erick mitochondria: an unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis
Source: Eur Respir J, 57 (4) 2004500; 10.1183/13993003.04500-2020
Year: 2021



mTOR signalling is an essential pathway for TGF-β1 induced collagen synthesis
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010


Extracellular HSP90a promotes cellular senescence in pulmonary fibrosis through TGFß signaling
Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more
Year: 2020


PP208 – SRC family kinases modulate molecular pathways associated with mitochondrial dysfunction in idiopathic pulmonary fibrosis
Source: ERS Lung Science Conference 2021
Year: 2021

Defective p53-mediated pro-apoptotic pathway in idiopathic pulmonary fibrosis
Source: Annual Congress 2008 - New insights into the pathogenesis of idiopathic pulmonary fibrosis and sarcoidosis
Year: 2008

TRIM33 prevents pulmonary fibrosis by impairing TGF-ß1 signalling
Source: Eur Respir J, 55 (6) 1901346; 10.1183/13993003.01346-2019
Year: 2020



PGAM5 acts as a key mediator of lung fibrosis by disrupting mitochondrial homeostasis
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

The potential role of antimicrobial peptides from wasp as regulators of the fibrotic process in idiopathic pulmonary fibrosis.
Source: International Congress 2019 – Assessment and management of immune-mediated interstitial lung diseases
Year: 2019

The matrix-fibroblast interplay contributes to HIF-1 alpha pathway activation: a possible therapeutic target in idiopathic pulmonary fibrosis (IPF)
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




The pathomechanistic role of autophagy in lung fibrosis
Source: International Congress 2017 – Interstitial lung diseases (ILDs): novel pathogenetic pathways
Year: 2017

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

SH2 domain-containing phosphatase-SHP-2 is a novel anti-fibrotic regulator in pulmonary fibrosis
Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis
Year: 2016



Regulation of alternative macrophage activation by galectin-3; potential role in lung fibrosis
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


The role of extracellular vesicles in phenotypic alteration of lung cells in pulmonary fibrosis
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013

Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis
Source: Eur Respir Rev, 29 (158) 190140; 10.1183/16000617.0140-2019
Year: 2020



Tranilast inhibits pulmonary fibrosis by suppressing TGFbeta-mediated extracellular matrix protein production
Source: Annual Congress 2013 –Diffuse pulmonary fibrosis
Year: 2013

Micro-RNA-125a/b target A20 and MAVS to promote inflammatory and impair antiviral responses in chronic obstructive pulmonary disease
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

PP121 – Gaq/11 and Ga12/13 promote pulmonary fibrosis by driving distinct myofibroblast functions
Source: ERS Lung Science Conference 2021
Year: 2021

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015