Connecting the dots: the role of connexins in the pulmonary vascular response to hypoxia

Martin Witzenrath, Wolfgang M. Kuebler

Source: Eur Respir J, 57 (3) 2004573; 10.1183/13993003.04573-2020
Journal Issue: March
Disease area: Pulmonary vascular diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Martin Witzenrath, Wolfgang M. Kuebler. Connecting the dots: the role of connexins in the pulmonary vascular response to hypoxia. Eur Respir J, 57 (3) 2004573; 10.1183/13993003.04573-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Stabilised ferroportin activity affects pulmonary vascular cells responses: implications for pulmonary hypertension
Source: International Congress 2018 – Experimental research in pulmonary hypertension
Year: 2018


Late Breaking Abstract - NGF induces pulmonary arterial hyperreactivity through increased connexin-43 expression: potential role in pulmonary hypertension
Source: International Congress 2018 – Molecular mechanisms and treatment of pulmonary hypertension
Year: 2018

Implication of aquaporin-1 in the stress response of human pulmonary microvascular endothelial cells
Source: International Congress 2019 – Biomarkers, laboratory findings and pre-clinical data in acute respiratory failure
Year: 2019


CFTR in the regulation of pulmonary vascular tone and remodeling
Source: Eur Respir J, 58 (6) 2101861; 10.1183/13993003.01861-2021
Year: 2021



Regulation of connexins by hypoxia in rat pulmonary vascular cells in an in vitro model of pulmonary hypertension
Source: International Congress 2017 – Experimental PH
Year: 2017


Endothelial NO and its pathophysiologic regulation
Source: Annual Congress 2007 - Role of the endothelium in pulmonary function and disease
Year: 2007


Pulmonary artery endothelial cell exposure to hepcidin affects BMP-signalling; relevance to vascular remodelling in PAH
Source: Virtual Congress 2020 – Experimental approaches to pulmonary hypertension
Year: 2020


Plasticity of vascular progenitor cells: implications in pulmonary vascular remodeling in COPD
Source: Eur Respir J 2006; 28: Suppl. 50, 803s
Year: 2006

Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms
Source: Eur Respir J 2008; 32: 1639-1651
Year: 2008



Mitophagy plays an important role in hypoxia-induced pulmonary artery smooth muscle cell proliferation
Source: Virtual Congress 2020 – Experimental approaches to pulmonary hypertension
Year: 2020

The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension
Source: Eur Respir J 2015; 45: 1758-1759
Year: 2015


The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension
Source: Eur Respir J 2015; 45: 1756-1758
Year: 2015


SMAD3 regulation contributes to lung vascular remodeling in pulmonary arterial hypertension
Source: International Congress 2015 – Respiratory translational research: novel mechanisms, diagnostic markers and Space Odyssey
Year: 2015



Involvement of FHL1 in vascular remodelling
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006


Actions of acute and chronic hypoxia on oxygen-sensing pulmonary vascular fibroblasts
Source: Annual Congress 2004 - Chronic tissue hypoxia and gene expression: a systems approach to adaptation
Year: 2004

Gene expression alterations in mice lacking the VIP gene are conducive to pulmonary arterial hypertension and pulmonary vascular remodeling
Source: Annual Congress 2007 - Cellular and molecular aspects of pulmonary hypertension
Year: 2007


Pulmonary vascular response to exercise in heart-failure patients with pulmonary hypertension: role of a pre-capillary component
Source: International Congress 2017 – Exercise and physiology in pulmonary hypertension
Year: 2017