Arrhythmogenic and chronotropic effects of bronchodilator drugs on human cardiomyocytes

M. Šcurek (Brno, Czech Republic), M. Pešl (Brno, Czech Republic), J. Pribyl (Brno, Czech Republic), Š. Klimovic (Brno, Czech Republic), T. Urban (Brno, Czech Republic), Š. Jelínková (Brno, Czech Republic), V. Rotrekl (Brno, Czech Republic), K. Brat (Brno, Czech Republic)

Source: Virtual Congress 2020 – Scientific advances in airway pharmacology
Session: Scientific advances in airway pharmacology
Session type: E-poster session
Number: 3297
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Šcurek (Brno, Czech Republic), M. Pešl (Brno, Czech Republic), J. Pribyl (Brno, Czech Republic), Š. Klimovic (Brno, Czech Republic), T. Urban (Brno, Czech Republic), Š. Jelínková (Brno, Czech Republic), V. Rotrekl (Brno, Czech Republic), K. Brat (Brno, Czech Republic). Arrhythmogenic and chronotropic effects of bronchodilator drugs on human cardiomyocytes. 3297

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Glycopyrrolate exerts medium-duration bronchodilator activity in guinea-pig and human airways
Source: Eur Respir J 2005; 26: Suppl. 49, 216s
Year: 2005

Beta-adrenergic blockade effects on aerobic capacity and chronotropic response
Source: Virtual Congress 2021 – Hypoxia, exercise and respiratory function in pathophysiological conditions
Year: 2021


Reversal of bronchoconstriction by inotropic drugs: comparison of dopamine, dobutamine, milrinone, adrenaline and levosimendan
Source: International Congress 2017 – Lung function testing
Year: 2017

The dual PDE3/PDE4 phosphodiesterase inhibitor RPL554 produces more complete bronchodilator responses than the beta2-agonist salbutamol and the anti-muscarinic agent ipratropium bromide, alone and in combination, in guinea-pig isolated trachea
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015


Abediterol has higher bronchodilatory potency and reduced cardiac effects versus other long-acting beta2-agonists in dogs
Source: International Congress 2014 – Rationale behind respiratory drug development
Year: 2014

Protective effect of inhaled anticholinergic drugs in the methacholine test
Source: Eur Respir J 2007; 30: Suppl. 51, 619s
Year: 2007

Pharmacodynamic effects of nebulised bronchodilator combinations
Source: Virtual Congress 2020 – Management of allergy, asthma and COPD
Year: 2020


Synergistic effects between glycopyrronium bromide and indacaterol on a muscarinic agonist-induced contraction in airway smooth muscle
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Involvement of the BK channels/G proteins processes in the synergistic effects between anticholinergic agents and beta2-adrenoceptor agonists in airway smooth muscle
Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management
Year: 2013


Adrenergic receptor blocker reverses cardiac metabolic remodeling and improves right ventricular function in experimental pulmonary hypertension
Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease
Year: 2011

Protective effect of inhaled iloprost on exercise-induced bronchoconstriction
Source: Eur Respir J 2004; 24: Suppl. 48, 443s
Year: 2004

An assessment of the functional profile of aclidinium in human bronchi and left atria
Source: Annual Congress 2011 - Translational models of disease
Year: 2011


Cardioprotective effects of inhaled corticosteroid-containing combination therapy in COPD
Source: Eur Respir J, 53 (2) 1802420; 10.1183/13993003.02420-2018
Year: 2019



Do long-acting β2-adrenoceptor agonists enhance the anti-inflammatory effect of glucocorticoids in asthma?
Source: Eur Respir J 2001; 17: 1059-1061
Year: 2001


The combination of budesonide and formoterol exerts more rapid and enhanced anti-inflammatory effects than either drug alone in rat lungs in vivo
Source: Eur Respir J 2004; 24: Suppl. 48, 344s
Year: 2004

Absence of respiratory effects in asthmatic subjects with the If inhibitor ivabradine, a novel anti-anginal agent
Source: Eur Respir J 2006; 28: Suppl. 50, 664s
Year: 2006

The bronchodilator effects of the novel anti-inflammatory compound TPI 1020, alone and in combination with formoterol, in conscious guinea pigs
Source: Annual Congress 2009 - Preclinical models in drug development
Year: 2009


Abediterol has higher bronchodilatory potency than other long-acting beta2-receptor agonists in a guinea pig model
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

α1-adrenoceptor antagonism does not modify the pulmonary vasoconstrictor effect of dexfenfluramine in the rat
Source: Eur Respir J 2001; 18: Suppl. 33, 491s
Year: 2001

Modulation of cholinergic contractions of airway smooth muscle by cathinone: potential beneficial effects in airway diseases
Source: Eur Respir J 2008; 32: 579-584
Year: 2008