The CDK4/6 inhibitor, palbociclib intensifies pulmonary inflammation in bleomycin-induced lung fibrosis

A. Birnhuber (Graz, Austria), B. Egemnazarov (Graz, Austria), V. Biasin (Graz, Austria), E. Rad (Graz, Austria), H. Olschewski (Graz, Austria), G. Kwapiszewska (Graz, Austria), L. Marsh (Graz, Austria)

Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Disease area: Interstitial lung diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Birnhuber (Graz, Austria), B. Egemnazarov (Graz, Austria), V. Biasin (Graz, Austria), E. Rad (Graz, Austria), H. Olschewski (Graz, Austria), G. Kwapiszewska (Graz, Austria), L. Marsh (Graz, Austria). The CDK4/6 inhibitor, palbociclib intensifies pulmonary inflammation in bleomycin-induced lung fibrosis. 2285

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PD98059 attenuates the development of bleomycin-induced lung injury and fibrosis
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2008 - Management of idiopathic pulmonary fibrosis: what can we learn from the pathophysiology?
Year: 2008

HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012

17(R)-resolvin D1 attenuates bleomycin-induced lung fibrosis in mice
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013


A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice
Source: Eur Respir J 2012; 40: 1475-1482
Year: 2012



Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 461s
Year: 2005

PAR-2 antagonist inhibits bleomycin-induced lung fibrosis.
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019


The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in rats
Source: Eur Respir J 2002; 20: Suppl. 38, 487s
Year: 2002

Effect of nintedanib on silica-induced lung inflammation and fibrosis in mice
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012


The PDE4 inhibitor roflumilast reduced bleomycin-induced pulmonary fibrotic and vascular remodeling in mice in vivo
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008

Antifibrotic effects of Lck inhibition on bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2019

Neutrophil elastase is necessary for increases in active TGF-β in bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2001; 18: Suppl. 33, 199s
Year: 2001

Effect of NF-?B inhibitor IMD-1041 on BLM-induced pulmonary fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017


Treprostinil administration attenuates bleomycin-induced lung fibrosis in mice
Source: International Congress 2015 – Interstitial lung diseases II
Year: 2015

Rho-kinase inhibitor ameliorates bleomycin-induced chronic lung injury in neonatal rats
Source: Annual Congress 2011 - Issues in paediatric and neonatal intensive care
Year: 2011

Sulforaphane attenuates lung fibrosis in bleomycin-induced pulmonary fibrosis via inhibition of TGF-beta/Smad signaling
Source: International Congress 2014 – ILDs 4
Year: 2014

Selective endothelin-A receptor blockade attenuates bleomycin-induced pulmonary inflammation and fibrosis in mice
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

The effect of interferon-γ on bleomycin-induced alveolitis and pulmonary fibrosis in rats
Source: Eur Respir J 2005; 26: Suppl. 49, 81s
Year: 2005

New approach to the treatment of bleomycin-induced lung fibrosis using pulmonary surfactant as pirfenidone carrier into the lung
Source: International Congress 2015 – Inflammation and remodelling in lung disease
Year: 2015

The role of expression of TLR 4 in bleomycin-induced pulmonary fibrosis in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013