Depletion rate of blood eosinophils with mepolizumab, benralizumab and oral prednisolone in patients with severe asthma

A. Moran (Oxford, United Kingdom), S. Ramakrishnan (Oxford, United Kingdom), C. Borg (Oxford, United Kingdom), C. Connolly (Oxford, United Kingdom), S. Couillard (Oxford, United Kingdom), C. Mwasuku (Oxford, United Kingdom), I. Pavord (Oxford, United Kingdom), T. Hinks (Oxford, United Kingdom), L. Lehtim?ki (Tampere, Finland)

Source: Virtual Congress 2020 – Monoclonal antibodies; randomised controlled trials and real-world studies in asthma
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Moran (Oxford, United Kingdom), S. Ramakrishnan (Oxford, United Kingdom), C. Borg (Oxford, United Kingdom), C. Connolly (Oxford, United Kingdom), S. Couillard (Oxford, United Kingdom), C. Mwasuku (Oxford, United Kingdom), I. Pavord (Oxford, United Kingdom), T. Hinks (Oxford, United Kingdom), L. Lehtim?ki (Tampere, Finland). Depletion rate of blood eosinophils with mepolizumab, benralizumab and oral prednisolone in patients with severe asthma. 2252

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Mepolizumab and the response to oral prednisolone in patients with severe eosinophilic asthma
Source: International Congress 2017 – Asthma management
Year: 2017

Treatment of moderate-severe asthma with omalizumab is associated with a decrease in peripheral blood eosinophils
Source: Eur Respir J 2007; 30: Suppl. 51, 353s
Year: 2007

Association between blood eosinophil count and exacerbation risk in patients with asthma receiving medium- or high-dosage inhaled corticosteroids
Source: International Congress 2017 – Biomarker-based asthma control
Year: 2017


Increase in systemic IL-5 is associated with mepolizumab treatment failure in patients with severe asthma
Source: International Congress 2018 – Role of IgE and interleukin (IL)-5 in Th2-cell signatures
Year: 2018

Anti-inflammatory effects of high-dose inhaled fluticasone versus oral prednisone in asthma exacerbations
Source: Eur Respir J 2007; 30: 1143-1149
Year: 2007



One year monitoring of children with bronchial asthma and other allergic diseases treated with inhaled corticosteroids vs cromoglycates with serum ECP (S-ECP), FEV1, total IgE and blood eosinophil count - the influence of different therapy
Source: Eur Respir J 2002; 20: Suppl. 38, 432s
Year: 2002

Decreasing dose protocol for omalizumab treatment in oral corticosteroid allergic asthma patients
Source: Annual Congress 2011 - Allergen immunotherapy and anti-immunoglobulin E
Year: 2011


Regulatory T cells and L-selectin in severe asthmatic patients treated with mepolizumab.
Source: Virtual Congress 2020 – Personalised treatment of obstructive diseases
Year: 2020


Evolution of patients with severe asthma treated with mepolizumab
Source: Virtual Congress 2020 – Monoclonal antibodies in asthma
Year: 2020


Evaluation of therapeutic response to anti-IL5 treatment in severe eosinophilic asthma patients no responders to omalizumab
Source: International Congress 2019 – Treatment of asthma with monoclonal antibodies
Year: 2019


High sputum eosinophils are associated with better response to inhaled corticosteroids in asthmatic patients
Source: Eur Respir J 2002; 20: Suppl. 38, 113s
Year: 2002

The effect of anti-IL-5 therapy on sputum cells and cytokines in asthmatics
Source: International Congress 2019 – Treatment of asthma with monoclonal antibodies
Year: 2019


The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
Source: Eur Respir J 2001; 18: 254-261
Year: 2001



Long-term safety and tolerability of omalizumab, an anti-IgE monoclonal antibody, in patients with severe allergic asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 48s
Year: 2005

Ciclesonide 80 μg once daily reduces early and late asthmatic reaction, sputum eosinophils and serum ECP in asthma patients challenged with allergens
Source: Eur Respir J 2005; 26: Suppl. 49, 254s
Year: 2005

Assessment and evaluation of symptomatic steroid-naive asthmatics without sputum eosinophilia and their response to inhaled corticosteroids
Source: Eur Respir J 2002; 20: 1364-1369
Year: 2002



Absence of sputum eosinophils in subjects with symptomatic asthma on inhaled budesonide
Source: Eur Respir J 2002; 20: Suppl. 38, 274s
Year: 2002

Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
Source: Eur Respir J, 51 (5) 1702523; 10.1183/13993003.02523-2017
Year: 2018



Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma
Source: Eur Respir J 2005; 25: 41-46
Year: 2005



Long-term asthma control with omalizumab, an anti-IgE monoclonal antibody, in patients with severe allergic asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 47s
Year: 2005