LSC - 2020 - Caspase-1 activation by cigarette smoke occurs via TLR4/TRIF/caspase-8 axis leading to metabolic alterations in human macrophages

M. Busceta (Palermo, Italy), S. Di Vincenzo (Palermo, Italy), E. Pace (Palermo, Italy), C. Cipollina (Palermo, Italy)

Source: Virtual Congress 2020 – Effects of environmental exposures on lung pathology
Session: Effects of environmental exposures on lung pathology
Session type: E-poster session
Number: 5387
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Busceta (Palermo, Italy), S. Di Vincenzo (Palermo, Italy), E. Pace (Palermo, Italy), C. Cipollina (Palermo, Italy). LSC - 2020 - Caspase-1 activation by cigarette smoke occurs via TLR4/TRIF/caspase-8 axis leading to metabolic alterations in human macrophages. 5387

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Caspase-1 activation by cigarette smoke occurs via TLR4/TRIF/caspase-8 axis leading to metabolic alterations in human macrophages
Source: ERS Lung Science Conference 2020
Year: 2020

LSC - 2020 - Cigarette smoke exposure disrupts the molecular regulation of mitochondrial metabolism in human bronchial and alveolar epithelial cells
Source: Virtual Congress 2020 – Effects of environmental exposures on lung pathology
Year: 2020


LSC - 2020 - Epithelial-mesenchymal transition induced by cigarette smoke in lung epithelial cells is associated with metabolic reprogramming and senescence
Source: Virtual Congress 2020 – Metabolic alterations and ageing in lung disease
Year: 2020




LSC - 2017 - IL-17-mediated inflammation promotes cigarette smoke-induced genomic instability
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

The AMPK-TSC1/2-mTOR signaling pathway regulates cigarette smoking-induced inflammation and apoptosis in airway epithelial cells
Source: International Congress 2015 – Molecular pathways of lung injury due to tobacco-related products
Year: 2015


Cigarette smoke impairs Sirt1 activity and promotes pro-inflammatory responses in bronchial epithelial cells
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Cigarette smoke activates ER overload response in Z-AT mice
Source: Annual Congress 2013 –The multiple faces of stress in lung injury
Year: 2013

Cigarette smoke induces mitochondrial dysfunction via PKCd-p66Shc signaling pathway in human bronchial epithelial cells
Source: International Congress 2018 – COPD: novel pathological mechanisms in the airway epithelium
Year: 2018

Cigarette smoke exposure decreases CFLAR expression in bronchial epithelium, augmenting susceptibility for cell death and DAMP release
Source: International Congress 2018 – Regenerative and anti-fibrotic approaches
Year: 2018



Aberrant airway epithelial differentiation resulting from cigarette smoke exposure leads to loss of constitutive antimicrobial peptide and protein (AMP) expression
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016

LSC - 2020 - IRF5 regulates airway macrophage metabolic responses to viral challenge
Source: Virtual Congress 2020 – Translational science in respiratory infections
Year: 2020


NDP52 inhibition rescues cigarette smoke mediated impairment of autophagy in macrophages
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016

A shift toward alternative activation in human alveolar macrophages: A response to chronic alcohol ingestion
Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2010


Cigarette smoke extract inhibits the NLRP3 inflammasome in human macrophages and impairs cell metabolism via NLRP3-independent activation of Caspase-1
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

Quercetin attenuates inflammation in cigarette smoke stimulated airway epithelial cells: Possible involvement of autophagy
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013


LSC 2010 Abstract: Inhibition of innate host defense in airway epithelial cells by cigarette smoke in an in vitro infection model caused by suppression of NF-κB activation
Source: Annual Congress 2010 - Epithelial cells: cell biology and role in lung disease
Year: 2010

LSC 2014 abstract - Increased myelopoiesis induced by cigarette smoke transiently increases kinetics of lung bacterial clearance in mice
Source: International Congress 2014 – Immunology of respiratory infections
Year: 2014


Tobacco smoke causes release of IL-16 protein from NK cells in vitro
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015


Cigarette smoke suppresses mast cell maturation and cytokine release independent of TLR4 signaling
Source: Annual Congress 2012 - Basic and translational studies in COPD
Year: 2012

Cigarette smoke extract induces the release of extracellular vesicles by airway epithelial cells via cellular carbonyl stress
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015