GB001 is a potent, insurmountable DP2 antagonist with long receptor residence time and extended pharmacodynamic effects

S. Sahdeo (San Diego, United States of America), K. Taylor Meadows (San Diego, United States of America), S. Hoare (Owego, United States of America), T. Kenakin (Raleigh-Durham, United States of America), S. Murphy (San Diego, United States of America), T. Salter-Cid (San Diego, United States of America), H. Ortega (San Diego, United States of America), G. Opiteck (San Diego, United States of America), L. Salter-Cid (San Diego, United States of America), L. Carter (San Diego, United States of America)

Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma
Session: Clinical and laboratory pharmacology in asthma
Session type: E-poster session
Number: 1420
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Sahdeo (San Diego, United States of America), K. Taylor Meadows (San Diego, United States of America), S. Hoare (Owego, United States of America), T. Kenakin (Raleigh-Durham, United States of America), S. Murphy (San Diego, United States of America), T. Salter-Cid (San Diego, United States of America), H. Ortega (San Diego, United States of America), G. Opiteck (San Diego, United States of America), L. Salter-Cid (San Diego, United States of America), L. Carter (San Diego, United States of America). GB001 is a potent, insurmountable DP2 antagonist with long receptor residence time and extended pharmacodynamic effects. 1420

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
In vitro pharmacological profile of CHF 5407, a potent, long-acting and selective muscarinic M3 receptor antagonist
Source: Eur Respir J 2007; 30: Suppl. 51, 25s
Year: 2007

Aclidinium bromide, a novel muscarinic receptor antagonist combining long residence at M3 receptors and rapid plasma clearance
Source: Annual Congress 2007 - New drugs for COPD
Year: 2007


AZD3199: A potent and selective β2-adrenergic receptor agonist with rapid onset of action
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011


The in vitro biology of Compound X – a novel β2 adrenoceptor agonist with a long duration of action
Source: Annual Congress 2008 - Novel treatments for respiratory disease
Year: 2008

In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407
Source: Eur Respir J 2007; 30: Suppl. 51, 26s
Year: 2007

Unique receptor dissociation kinetics of the novel endothelin receptor antagonist macitentan
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Ligand independent activation of the glucocorticoid receptor by long acting β2 agonists
Source: Eur Respir J 2004; 24: Suppl. 48, 317s
Year: 2004

Lack of relevant pharmacokinetic and pharmacodynamic interactions between the new dual endothelin receptor antagonist macitentan and warfarin in healthy subjects
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Lack of relevant pharmacokinetic interactions between the new dual endothelin receptor antagonist macitentan and sildenafil in healthy subjects
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


PKA/cAMP-independent transactivation of glucocorticoid receptor by long acting β2 agonists
Source: Eur Respir J 2006; 28: Suppl. 50, 103s
Year: 2006

Preclinical safety profile of oral SCH 527123, a novel antagonist of CXCR2
Source: Annual Congress 2007 - Miscellaneous pulmonary pharmacology II
Year: 2007


AZD3199: A fast acting β2-receptor agonist with a long duration of action
Source: Annual Congress 2011 - Translational models of disease
Year: 2011

The dual endothelin receptor antagonist bosentan reduces TNFα induced GM-CSF release more effectively than the endothelin A receptor antagonist ambrisentan
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010

Mas receptor antagonist inhibits the pro-resolutive effects of Angiotensin-(1-7) in an experimental model of asthma.
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

The novel dual D2 dopamine receptor, β2-adrenoceptor agonist Viozan™ (AR-C68397AA) is well tolerated in a dog model
Source: Eur Respir J 2001; 18: Suppl. 33, 406s
Year: 2001

Vasopressin is involved in endothelin receptor antagonist-induced fluid retention in rat. Differential effect of selective ETA and dual ETA/ETB receptor antagonists
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Efficacy of sitaxsentan, an endothelin-A receptor antagonist in PAH in traditional vs. expanded study populations
Source: Eur Respir J 2004; 24: Suppl. 48, 109s
Year: 2004

Effects of oral SCH 527123, a CXCR2 antagonist, on acquired immunity in healthy adults
Source: Annual Congress 2007 - New insights into the treatment of COPD
Year: 2007


Safety and toleration of pf-00610355, a novel inhaled long acting β2 adrenoreceptor agonist
Source: Annual Congress 2009 - New bronchodilators
Year: 2009

Pharmacological activities of R-113281, a triple NK1 /NK2 /NK3 neurokinin receptor antagonist
Source: Eur Respir J 2001; 18: Suppl. 33, 264s
Year: 2001